Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.

Generalized Anxiety Disorder (GAD) presents a high prevalence in the population, leading to distress and disability. Immune system alterations have been associated with anxiety-related behaviors in rodents and GAD patients. CD300f immune receptors are highly expressed in microglia and participate not only in the modulation of immune responses but also in pruning and reshaping synapses. It was recently demonstrated that CD300f might be influential in the pathogenesis of depression in a sex-dependent manner. Here, we evaluated the role of CD300f immune receptor in anxiety, using CD300f knockout mice (CD300f-/-) and patients with GAD. We observed that male CD300f-/- mice had numerous behavioral changes associated with a low-anxiety phenotype, including increased open field central locomotion and rearing behaviors, more exploration in the open arms of the elevated plus-maze test, and decreased latency to eat in the novelty suppressed feeding test. In a cross-sectional population-based study, including 1111 subjects, we evaluated a common single-nucleotide polymorphism rs2034310 (C/T) in the cytoplasmatic tail of CD300f gene in individuals with GAD. Notably, we observed that the T allele of the rs2034310 polymorphism conferred protection against GAD in men, even after adjusting for confounding variables. Overall, our data demonstrate that CD300f immune receptors are involved in the modulation of pathological anxiety behaviors in a sex-dependent manner. The biological basis of these sex differences is still poorly understood, but it may provide significant clues regarding the neuropathophysiological mechanisms of GAD and can pave the way for future specific pharmacological interventions

Introduction to “Binary Binds”: Deconstructing Sex and Gender Dichotomies in Archaeological Practice

YesGender archaeology has made significant strides toward deconstructing the hegemony of binary categorizations. Challenging dichotomies such as man/woman, sex/gender, and biology/culture, approaches informed by poststructuralist, feminist, and queer theories have moved beyond essentialist and universalist identity constructs to more nuanced configurations. Despite the theoretical emphasis on context, multiplicity, and fluidity, binary starting points continue to streamline the spectrum of variability that is recognized, often reproducing normative assumptions in the evidence. The contributors to this special issue confront how sex, gender, and sexuality categories condition analytical visibility, aiming to develop approaches that respond to the complexity of theory in archaeological practice. The papers push the ontological and epistemological boundaries of bodies, personhood, and archaeological possibility, challenging a priori assumptions that contain how sex, gender, and sexuality categories are constituted and related to each other. Foregrounding intersectional approaches that engage with ambiguity, variability, and difference, this special issue seeks to “de-contain” categories, assumptions, and practices from “binding” our analytical gaze toward only certain kinds of persons and knowledges, in interpretations of the past and practices in the present

Shifting Ground: Rethinking Concepts of Continuity and Change in Late Iron Age and Early Roman Landscapes of Southern England

What kinds of landscapes does the segmentation of space and time by the Late Iron Age/Early Roman transition create, include, and exclude? What continues, changes, and co-exists, and how is the landscape interconnected in the context of these negotiations? This thesis re-conceptualizes continuity and change during the Late Iron Age (100 BCE–CE 43) and Early Roman period (CE 43–CE 150/200) in southern England, exploring how relationships with place and landscape generate the contexts for community formation and transformation. Despite the deconstruction of the traditional acculturation paradigm—Romanization—it has proven difficult to circumvent binary categories of identity and process that relegate continuity to a static and undifferentiated pre-baseline temporal moment and equate transformation to Roman imposition. Tracing how the place biographies of seven case study sites in Dorset (southwest) and the Middle Thames Valley (southeast) interconnect with regional settlement patterns, including urban and rural dynamics, the project evaluates the variability of the case study sites in relation to documented post-conquest trends in terms of structure shape, construction materials, pottery, herd structure, and crop composition. It is argued that the dynamics of practice cannot be contained by a past and present divided by the conquest baseline, and consequently, that continuity and change cannot be confined to spaces and materials originating on one or the other side of that temporal moment—continuity and change are dynamic and interactive rather than ontologically separate outcomes of imperial occupation. An approach is suggested that removes the traditional change–continuity axis as the primary context of interpretation, re-articulating how time, place, and material culture are linked to process and identity. Relationships with place point to deep, multi-temporal landscape histories incorporating Neolithic and Bronze Age monuments, crosscutting the Iron Age context as a bounded past prior to the imperial transition. GIS spatial analysis of settlement concentration and cycles of activity in Dorset (79 sites) and the Middle Thames Valley (78 sites) suggest more plural landscapes than can be explained by a single trend toward urban centralization. Shifting patterns of inhabitation, working within long-term yet dynamic settings for interaction, may have worked to maintain and renegotiate a context of communities interconnected across a heterogeneous landscape. The analysis is framed by an approach to structuring inquiry that emphasizes possibilities—the multiple tendencies of the past and present. The conceptual framework engages with the multidirectional processes and simultaneous differences of persistence and transformation, dynamics often excluded by the hegemonic temporality and territory of the traditional Romanization-as-acculturation paradigm

Sex-dependent role of CD300f immune receptor in generalized anxiety disorder

Generalized Anxiety Disorder (GAD) presents a high prevalence in the population, leading to distress and disability. Immune system alterations have been associated with anxiety-related behaviors in rodents and GAD patients. CD300f immune receptors are highly expressed in microglia and participate not only in the modulation of immune responses but also in pruning and reshaping synapses. It was recently demonstrated that CD300f might be influential in the pathogenesis of depression in a sex-dependent manner. Here, we evaluated the role of CD300f immune receptor in anxiety, using CD300f knockout mice (CD300f−/−) and patients with GAD. We observed that male CD300f−/− mice had numerous behavioral changes associated with a low-anxiety phenotype, including increased open field central locomotion and rearing behaviors, more exploration in the open arms of the elevated plus-maze test, and decreased latency to eat in the novelty suppressed feeding test. In a cross-sectional population-based study, including 1111 subjects, we evaluated a common single-nucleotide polymorphism rs2034310 (C/T) in the cytoplasmatic tail of CD300f gene in individuals with GAD. Notably, we observed that the T allele of the rs2034310 polymorphism conferred protection against GAD in men, even after adjusting for confounding variables. Overall, our data demonstrate that CD300f immune receptors are involved in the modulation of pathological anxiety behaviors in a sex-dependent manner. The biological basis of these sex differences is still poorly understood, but it may provide significant clues regarding the neuropathophysiological mechanisms of GAD and can pave the way for future specific pharmacological interventions