1,348 research outputs found
Evidence for narrow resonant structures at and GeV in real Compton scattering off the proton
First measurement of the beam asymmetry for Compton scattering off
the proton in the energy range GeV is presented. The
data reveals two narrow structures at and
GeV. They may signal narrow resonances with masses near
and GeV, or they may be generated by the sub-threshold
and production. Their decisive identification requires additional
theoretical and experimental efforts.Comment: Published versio
Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study
<p>Abstract</p> <p>Background</p> <p>Lung injury caused by both inhaled dusts and infectious agents depends on increased availability of iron and metal-catalyzed oxidative stress. Because inhaled particles, such as silica, and certain infections can cause secondary pulmonary alveolar proteinosis (PAP), we tested the hypothesis that idiopathic PAP is associated with an altered iron homeostasis in the human lung.</p> <p>Methods</p> <p>Healthy volunteers (n = 20) and patients with idiopathic PAP (n = 20) underwent bronchoalveolar lavage and measurements were made of total protein, iron, tranferrin, transferrin receptor, lactoferrin, and ferritin. Histochemical staining for iron and ferritin was done in the cell pellets from control subjects and PAP patients, and in lung specimens of patients without cardiopulmonary disease and with PAP. Lavage concentrations of urate, glutathione, and ascorbate were also measured as indices of oxidative stress.</p> <p>Results</p> <p>Lavage concentrations of iron, transferrin, transferrin receptor, lactoferrin, and ferritin were significantly elevated in PAP patients relative to healthy volunteers. The cells of PAP patients had accumulated significant iron and ferritin, as well as considerable amounts of extracellular ferritin. Immunohistochemistry for ferritin in lung tissue revealed comparable amounts of this metal-storage protein in the lower respiratory tract of PAP patients both intracellularly and extracellularly. Lavage concentrations of ascorbate, glutathione, and urate were significantly lower in the lavage fluid of the PAP patients.</p> <p>Conclusion</p> <p>Iron homeostasis is altered in the lungs of patients with idiopathic PAP, as large amounts of catalytically-active iron and low molecular weight anti-oxidant depletion are present. These findings suggest a metal-catalyzed oxidative stress in the maintenance of this disease.</p
Separate and overlapping functional roles for efference copies in the human thalamus
How the perception of space is generated from the multiple maps in the brain is still an unsolved mystery in neuroscience. A neural pathway ascending from the superior colliculus through the medio-dorsal (MD) nucleus of thalamus to the frontal eye field has been identified in monkeys that conveys efference copy information about the metrics of upcoming eye movements. Information sent through this pathway stabilizes vision across saccades. We investigated whether this motor plan information might also shape spatial perception even when no saccades are performed. We studied patients with medial or lateral thalamic lesions (likely involving either the MD or the ventrolateral (VL) nuclei). Patients performed a double-step task testing motor updating, a trans-saccadic localization task testing visual updating, and a localization task during fixation testing a general role of motor signals for visual space in the absence of eye movements. Single patients with medial or lateral thalamic lesions showed deficits in the double-step task, reflecting insufficient transfer of efference copy. However, only a patient with a medial lesion showed impaired performance in the trans-saccadic localization task, suggesting that different types of efference copies contribute to motor and visual updating. During fixation, the MD patient localized stationary stimuli more accurately than healthy controls, suggesting that patients compensate the deficit in visual prediction of saccades - induced by the thalamic lesion - by relying on stationary visual references. We conclude that partially separable efference copy signals contribute to motor and visual stability in company of purely visual signals that are equally effective in supporting trans-saccadic perception
Experimental and numerical analysis of supersonic blade profiles developed for highly loaded impulse type steam turbine stages
The paper describes the results of a numerical and experimental research program addressing the aerodynamic investigation on the performance of blade profiles specifically developed for application in highly loaded impulse type turbine stages. The industrial requirements driving toward the adoption of highly loaded stage solutions are presented, along with an estimation of the profiles operating parameters. Two stator vanes and one rotor blade profile have been developed and extensively tested by means of flow field measurements and schlieren visualization in a transonic blow-down wind tunnel for linear cascades. Experimental results for the relevant operating conditions are presented, providing validation data for the CFD model used for blade design and evidencing that the main goals of the design optimization procedure have been achieved
Is Venice an ideal habitat for Legionella pneumophila?
Introduction. Legionella bacterium manifests itself in Legion- naire?s disease and Pontiac fever, it is mainly found and trans- mitted by aerosol produced in cooling towers, water distribution plants and medical equipment, and it affects mainly elder persons in poor health.
Methods. The population of Venice Local Health Unit was divided in two areas of study and the incidence of legionellosis in residents of Venice historical centre (Distretto Sanitario 1) and in residents of the mainland and coastal areas (Distretti Sanitari 2, 3, 4) was calculated. The cases were those notified to the Public Health Unit by law, and the population of residents was that of the eligible for health care in the archives of the Local Health Unit. Only cases of legionellosis in residents who had not travelled in the 10 days previous of the onset of disease, and not related to nosocomial clusters were considered. The standardized incidence ratio was then calculated and confidence interval were defined by Poisson distribution.
Results. Given the population of the two areas, 59801 in Distretto Sanitario 1 and 237555 in Distretti 2, 3, 4, the raw incidence of disease is respectively 87 per 100000 and 20 per 100000 in time 2002-2010. The standardized incidence ratio for the population of Distretto Sanitario 1 vs the remaining population is 4.3. Discussion. The difference in risk of getting the disease in this two residential areas geographically very close, is probably related to the different buildings? characteristics, old and difficult to main- tain in Venice historical centre
Hashimoto’s encephalopathy in a patient with septal panniculitis: a case report
Hashimoto’s encephalopathy (HE) is an autoimmune form of encephalopathy, associated with autoimmune thyroiditis. Its prevalence is estimated to be 2:100,000. HE is characterized by behavioral changes, mental confusion, dysarthria, ataxia, psychosis, paranoia, convulsions, hallucinations, headache and hyperthermia. Elevated thyroid antibodies are necessary for diagnosis and the disease responds dramatically to glucocorticoid therapy. We describe a patient with HE and panniculitis, an association reported twice in the literature
The GRAAL high resolution BGO calorimeter and its energy calibration and monitoring system
We describe the electromagnetic calorimeter built for the GRAAL apparatus at
the ESRF. Its monitoring system is presented in detail. Results from tests and
the performance obtained during the first GRAAL experiments are given. The
energy calibration accuracy and stability reached is a small fraction of the
intrinsic detector resolution.Comment: 19 pages, 14 figures, submitted to Nuclear Instruments and Method
Shedding New Light on Kaon-Nucleon/Nuclei Interaction and Its Astrophysical Implications with the AMADEUS Experiment at DAFNE
The AMADEUS experiment deals with the investigation of the low-energy
kaon-nuclei hadronic interaction at the DA{\Phi}NE collider at LNF-INFN, which
is fundamental to respond longstanding questions in the non-perturbative QCD
strangeness sector. The antikaon-nucleon potential is investigated searching
for signals from possible bound kaonic clusters, which would open the
possibility for the formation of cold dense baryonic matter. The confirmation
of this scenario may imply a fundamental role of strangeness in astrophysics.
AMADEUS step 0 consisted in the reanalysis of 2004/2005 KLOE dataset,
exploiting K- absorptions in H, 4He, 9Be and 12C in the setup materials. In
this paper, together with a review on the multi-nucleon K- absorption and the
particle identification procedure, the first results on the {\Sigma}0-p channel
will be presented including a statistical analysis on the possible accomodation
of a deeply bound stateComment: 6 pages, 2 figure, 1 table, HADRON 2015 conferenc
Deuteron photo-disintegration with polarised photons in the energy range 30 - 50 MeV
The reaction d(\vec\gamma,np) has been studied using the tagged and polarised
LADON gamma ray beam at an energy 30 - 50 MeV to investigate the existence of
narrow dibaryonic resonances recently suggested from the experimental
measurements in a different laboratory. The beam was obtained by Compton
back-scattering of laser light on the electrons of the storage ring ADONE.
Photo-neutron yields were measured at five neutron angle \vartheta_n = 22,
55.5, 90, 125 and 157 degrees in the center of mass system.Our results do not
support the existence of such resonances.Comment: 16 pages, Latex, 22 figures, 1 table. Nucl. Phys. A to appea
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