Autism in Down’s syndrome: a family history study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73253/1/j.1365-2788.2000.00271.x.pd

Brief report: Haloperidol treatment of trichotillomania in a boy with autism and mental retardation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44605/1/10803_2005_Article_BF02207333.pd

Depression in Persons with Autism: Implications for Research and Clinical Care

Although several studies have investigated the occurrence of medical and neurological conditions in persons with autism, relatively few reports have focused on the phenomenology and treatment of psychiatric disorders in this population. There is emerging evidence that depression is probably the most common psychiatric disorder that occurs in autistic persons. In this review, we examine the factors that influence the presence of depression in this population, such as the level of intelligence, age, gender, associated medical conditions, and the role of genetic factors and life events. We discuss the various forms of treatment available and highlight the need for early detection.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44620/1/10803_2004_Article_374852.pd

Brief report: Violence in asperger syndrome, a critique

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44604/1/10803_2005_Article_BF02207331.pd

Autistic symptoms following herpes encephalitis

Autism is a childhood onset neurodevelopmental disorder characterized by reciprocal social deficits, communication impairment, and rigid ritualistic interests, with the onset almost always before three years of age. Although the etiology of the disorder is strongly influenced by genes, environmental factors are also important. In this context, several reports have described its association with known medical conditions, including infections affecting the central nervous system. In this report, we describe an 11-year-old Asian youngster who developed the symptoms of autism following an episode of herpes encephalitis. In contrast to previous similar reports, imaging studies suggested a predominant involvement of the frontal lobes. At follow-up after three years, he continued to show the core deficits of autism. This case further supports the role of environmental factors, such as infections, in the etiology of autism, and suggests that in a minority of cases, autistic symptoms can develop in later childhood.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42465/1/787-11-3-142_20110142.pd

Brief report: A comparison of the diagnostic criteria for Asperger syndrome

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44608/1/10803_2005_Article_BF01046332.pd

Is megalencephaly specific to autism?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72452/1/j.1365-2788.1999.00211.x.pd

Asperger syndrome and clumsiness

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44610/1/10803_2005_Article_BF01046112.pd

Expanding the phenotypic spectrum of MBOAT7‐related intellectual disability

MBOAT7 gene pathogenic variants are a newly discovered and rare cause for intellectual disability, autism spectrum disorder (ASD), seizures, truncal hypotonia, appendicular hypertonia, and below average head sizes (ranging from −1 to −3 standard deviations). There have been only 16 individuals previously reported who have MBOAT7‐related intellectual disability, all of whom were younger than 10 years old and from consanguineous relationships. Thus, there is a lack of phenotypic information for adolescent and adult individuals with this disorder. Medical genetics and psychiatric evaluations in a 14‐year‐old female patient with a history of global developmental delay, intellectual disability, overgrowth with macrocephaly, metrorrhagia, seizures, basal ganglia hyperintensities, nystagmus, strabismus with amblyopia, ASD, anxiety, attention deficit hyperactivity disorder (ADHD), aggressive outbursts, and hyperphagia included a karyotype, methylation polymerase chain reaction for Prader‐Willi/Angelman syndrome, chromosome microarray, and whole exome sequencing (WES), ADOS2, and ADI‐R. WES identified a homozygous, likely pathogenic variant in the MBOAT7 gene (c.855‐2A>G). This is the oldest known patient with MBOAT7‐related intellectual disability, whose unique features compared with previously described individuals include overgrowth with macrocephaly, metrorrhagia, ophthalmological abnormalities, basal ganglia hyperintensities, unspecified anxiety disorder, and ADHD; combined type; and hyperphagia with the absence of appendicular hypertonia and cortical atrophy. More individuals need to be identified in order to delineate the full clinical spectrum of this disorder.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151268/1/ajmgb32749_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151268/2/ajmgb32749.pd

Anxiety contributes to suicidality in depressed adolescents

Several studies have suggested a positive association between anxiety symptoms and suicidality in adults. However, relatively little is known about this topic in adolescents. To investigate this issue, we examined a group of adolescents admitted to our psychiatric inpatient unit. Fifty-six adolescents (mean age = 14.8±1.4; females = 34, males = 22; race = 95% Caucasians) participated in the study. Diagnoses were made using the DSM-III-R criteria and a diagnostic interview. Anxiety was found to significantly correlate with depression (r = .60; P = < .05) and suicidality (r = .72; P < .05). A multiple regression analysis revealed that anxiety and depression together accounted for more than half (55%) of the variance in suicidal ideation [F(2,46) = 28.4; P < .0001]. In addition, anxiety had an independent ability to predict suicidality (t = 5.01; P < .0001). Self-rated but not clinician-rated suicidality was positively correlated with both anxiety and depression. Clinical and research implications of these findings are discussed. Depression and Anxiety 11:134–138, 2000. © 2000 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/35218/1/9_ftp.pd