Viagra exposure effects on learning and memory, some neurotransmitters and oxidative indices in male mice

Background: Viagra is a white crystalline powder, with a molecular weight of 666.7, covered with a blue shell and takes the shape of a diamond or a rhombus. Male Swiss white mice were used to study the effect of Viagra on learning behavior, some neurotransmitters, and indicators of oxidative stress. In the Shuttle box, Water-maze, and T-Maze tests, Viagra -treated males showed decreased body weight and improved learning behavior. Aim: The purpose of this study is to determine the effect of Viagra oral administration on learning behavior, neurotransmitters, and oxidative markers in male mice. Methods: In this study, Dopamine (DA), 5-hydroxyanisole (5-HA) and acetylcholinesterase (AchE) were all downregulated. Biochemical assays such as glutathione (GSH) and enzyme activity of Glutathione S Transferase (GST), Catalase (CAT), and superoxide dismutase (SOD) and Thiobarbituric acid relative substances (TBARS) was studied. Results: The results of this study show that the shuttle box test, Viagra exposure, water maize test, and t-maize test were all associated (p < 0.05). Exposure to Viagra decreased DA, 5-HT, AChE, GSH, GST, CAT, and SOD, although TBARS was significantly (p < 0.001) increased compared to their control groups. Conclusion: This study contained the necessary explanations that explain the causes of the effect of Viagra on learning and other data, depending on the results obtained and other previous studies in this field. In general, Viagra still needs more studies to detect its harmful effects on other aspects of human and animal health