Identification of 12 genetic loci associated with human healthspan

Aleksandr Zenin et al. present a genome-wide association study and genetic risk model for human healthspan, the length of morbidity-free life. They identify 12 loci associated with healthspan and osbserve genetic correlations between healthspan and life-history and lifestyle traits, such as obesity and smoking

Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo

We report preliminary results and a summary of a bottom-up approach to identify new, active, nontoxic, small-molecule antivirals designed to have а novel mechanism of action. We employed the procedure to identify 3-mercapto-1,2,4-triazoles derivatives as potential NP inhibitors in silico and subsequently demonstrated the in vitro efficacy of the molecules against various strains of the influenza A virus. The most efficacious compounds were successfully tested in an in vivo influenza challenge experiment