Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care

Introduction: This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating the potential of early treatment with oral semaglutide. Methods: A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals with T2D. A scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, and physician judgments on treatment appropriateness. Participants completed anonymous patient questionnaires reflecting routine clinical encounters. The preferred therapeutic regimen for each patient was also identified. Results: The analysis was conducted on 4449 patients initiating oral semaglutide. The population had a relatively short disease duration (42%  60% of patients, and more often than sitagliptin or empagliflozin. Conclusion: The study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management

The challenging direct measurement of the 65

The 17O(p, γ)18F reaction plays a crucial role in AGB nucleosynthesis as well as in explosive hydrogen burning occurring in type Ia novae. At the temperatures of interest for the former scenario ( 20MK < T < 80MK) the main contribution to the astrophysical reaction rate comes from the poorly constrained ER = 65 keV resonance. The strength of this resonance is presently determined only through indirect measurements, with an adopted value ωγ =(16 ± 3) peV. A new high sensitivity setup was installed at LUNA, located at LNGS. The underground location of the LUNA 400kV accelerator guarantees a reduction of the cosmic ray background by several orders of magnitude. The residual background was further reduced installing a devoted shielding. On the other hand, to increase the efficiency, the 4π BGO detector was coupled with Al target chamber and holder. With more than 400C accumulated on Ta2O5 targets, nominal 17O enrichment of 90%, the LUNA collaboration has performed the first direct measurement of the 65 keV resonance strength

The challenging direct measurement of the 65 keV resonance strength of the

A precise determination of proton capture rates on oxygen is mandatory to predict the abundance ratios of the oxygen isotopes in a stellar environment where hydrogen burning is active. The 17O(p,γ)18F reaction, specifically, plays a crucial role in AGB nucleosynthesis as well as in explosive hydrogen burning occurring in type Ia novae. At temperatures of interest for the former scenario (20 MK ≤ T ≤ 80 MK) the main contribution to the astrophysical reaction rate comes from the Ec.m. = 65 keV resonance. The strength of this resonance is presently determined only through indirect measurements, with an adopted value of ωγ = (1.6 ± 0.3) × 10−11 eV. Thanks to the low background environment of the Laboratori Nazionali del Gran Sasso, the intense and stable beam provided by the LUNA 400 kV accelerator and the experience in oxygen target production, the LUNA collaboration is aiming the first direct measurement of the above mentioned resonance strength. In the present work details of challenging direct measurement planned at LUNA will be described

Advances in radiative capture studies at LUNA with a segmented BGO detector

Studies of charged-particle reactions for low-energy nuclear astrophysics require high sensitivity, which can be achieved by means of detection setups with high efficiency and low backgrounds, to obtain precise measurements in the energy region of interest for stellar scenarios. High-efficiency total absorption spectroscopy is an established and powerful tool for studying radiative capture reactions, particularly if combined with the cosmic background reduction by several orders of magnitude obtained at the Laboratory for Underground Nuclear Astrophysics (LUNA). We present recent improvements in the detection setup with the Bismuth GermaniumOxide (BGO) detector at LUNA, aiming to reduce high-energy backgrounds and to increase the summing detection efficiency. The new design results in enhanced sensitivity of the BGO setup, as we demonstrate and discuss in the context of the first direct measurement of the 65 keV resonance (Ex = 5672 keV) of the 17O(p, γ)18F reaction. Moreover, we show two applications of the BGO detector, which exploit its segmentation. In case of complex γ-ray cascades, e. g. the de-excitation of Ex = 5672 keV in 18F, the BGO segmentation allows to identify and suppress the beam induced background signals that mimic the sum peak of interest. We demonstrate another new application for such a detector in form of in-situ activation measurementsof a reaction with β+ unstable product nuclei, e. g., the 14N(p, γ)15O reactio