Intestinal microbiota in human health and disease: the impact of probiotics

The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the intestinal microbiota. Here, we summarise the present state of the art on the intestinal microbiota with specific attention for the application of high-throughput functional microbiomic approaches to determine the contribution of the intestinal microbiota to human health. Moreover, we review the association between dysbiosis of the microbiota and both intestinal and extra-intestinal diseases. Finally, we discuss the potential of probiotic microorganism to modulate the intestinal microbiota and thereby contribute to health and well-being. The effects of probiotic consumption on the intestinal microbiota are addressed, as well as the development of tailor-made probiotics designed for specific aberrations that are associated with microbial dysbiosis

Peri-operative outcome for day-case laparoscopic and open inguinal hernia repair.

This study documents the results obtained in 30 day patients undergoing open hernia repair under local infiltration block with patient-controlled sedation (group A) and 29 day patients undergoing laparoscopic hernia repair under general anaesthesia (group B). The mean operating time was less in group A (44.8 min) compared with group B (66.6 min) (p < 0.0001). Similarly, stage 1 recovery room times were longer in group B (98.1 min) than group A (45.1 min) (p < 0.0001). Time to discharge for group A (139.1 min) was significantly shorter than group B (224.2 min) (p < 0.002), with more peri-operative complications occurring in group B and greater analgesic requirements. An open inguinal hernia repair under local infiltration block is the optimal approach for unilateral non-recurrent herniae as a day surgical procedure. These results have important cost and efficiency implications

The interrelationships between television viewing, values and perceived well-being: A global perspective

Do global marketing efforts, for example, those using television as a medium, impact on the values and life satisfaction of people, and, if so, is the process similar or different in various regions of the world? We empirically examine the relationship between television viewing, core values (i.e., religiosity and materialism), and perceived well-being factors (e.g., perceived socioeconomic status and relative life satisfaction). Data collected from the Western developed nations (e.g., United States and New Zealand) and several culturally homogeneous regions, including New Europe, Latin America, the Middle East, and the Far and Southeast, support the prevalence of diverse consumptionscapes with multiple global consumer cultures, rather than a single global culture. Globalization and advances in technology have not created global norms and homogenized our identities, but behavioral patterns and regional identities that are surprisingly durable. Specifically, materialism was shown to influence perceived socioeconomic status both positively (for two regions) and negatively (for two regions), and relative life satisfaction (except in New Europe), while perceived socioeconomic status had a positive influence on relative life satisfaction (except in New Europe and Latin America). The quantity of television viewing was positively shown to influence materialism, directly in some cases, as well as through perceived realism in others, providing limited support for the cultivation theory effect. Finally, religiosity was shown to play a countervailing role in negatively influencing materialism only in Latin American and Middle Eastern countries, and a positive influence on relative life satisfaction only in Latin America. The rationale behind the differences across regions was also explored. The overall results can perhaps be best explained by “postmodern” epistemologies, in which people worldwide are increasingly implicated, and in which new traditions are constantly being invented. Journal of International Business Studies (2008) 39, 1197–1219. doi:10.1057/palgrave.jibs.8400359