Chloramphenicol-induced stabilization of light-harvesting complexes in thylakoids during development

AbstractChloramphenicol treatment allows light-harvesting apoprotein accumulation in thylakoids of intermittent light plants and prevents its digestion in plants transferred to darkness after brief pre-exposure to continuous light. This suggests that under conditions where reaction center-core protein synthesis is inhibited, the light-harvesting apoproteins can be stabilized. The results support the competition hypothesis proposed to occur between reaction center polypeptides and light-harvesting apoproteins for chlorophyll, whenever the rate of chlorophyll formation relative to that of the polypeptide components is limited

Does Smoking Affect OSA? What about Smoking Cessation?

The connection between smoking and Obstructive sleep apnea (OSA) is not yet clear. There are studies that have confirmed the effect of smoking on sleep disordered breathing, whereas others did not. Nicotine affects sleep, as smokers have prolonged total sleep and REM latency, reduced sleep efficiency, total sleep time, and slow wave sleep. Smoking cessation has been related with impaired sleep. The health consequences of cigarette smoking are well documented, but the effect of smoking cessation on OSA has not been extensively studied. Smoking cessation should improve OSA as upper airway oedema may reduce, but there is limited data to support this hypothesis. The impact of smoking cessation pharmacotherapy on OSA has been studied, especially for nicotine replacement therapy (NRT). However, there are limited data on other smoking cessation medications as bupropion, varenicline, nortriptyline, clonidine, and cytisine. The aim of this review was to explore the current evidence on the association between smoking and OSA, to evaluate if smoking cessation affects OSA, and to investigate the possible effects of different pharmacologic strategies offered for smoking cessation on OSA