Screening a Peptide Library by DSC and SAXD: Comparison with the Biological Function of the Parent Proteins

We have recently identified the membranotropic regions of the hepatitis C virus proteins E1, E2, core and p7 proteins by observing the effect of protein-derived peptide libraries on model membrane integrity. We have studied in this work the ability of selected sequences of these proteins to modulate the Lβ-Lα and Lα-HII phospholipid phase transitions as well as check the viability of using both DSC and SAXD to screen a protein-derived peptide library. We demonstrate that it is feasible to screen a library of peptides corresponding to one or several proteins by both SAXD and DSC. This methodological combination should allow the identification of essential regions of membrane-interacting proteins which might be implicated in the molecular mechanism of membrane fusion and/or budding

Computational studies of the E. coli glycerol transporter, GlpF

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

EOS 2023 Workshop

Antares is the new tape archive service at RAL Tier-1 that went into production on 4th of March 2022. The service is built around the EOS/CTA technologies developed at CERN. EOS is the user facing service that manages the incoming namespace requests and a thin SSD buffer, and CTA is deployed as the tape back-end system. In this talk, we describe the setup of ANTARES and discuss the service’s performance as well as the main operational issues since the beginning of LHC Run-3. Finally, we provide an overview of the future plans for the expansion of the service to cover the whole of the high energy physics and astronomy community in the UK

EOS workshop

This talk will present details of the deployment of Antares, the EOS-CTA service at RAL Tier-1, which replaces Castor

CERN Tape Archive Workshop : CTA 2024

Antares is the tape archive service at RAL that manages both Tier-1 and local Facilities data. In this talk, we present the main developments in the service since last year’s CTA workshop including the migration of CASTOR Facilities instance and discuss the service’s performance as well as the main operational issues since the beginning of LHC Run-3. Finally, we provide an overview of the future plans for the expansion of the service to cover additional use cases from physics (CLF) and astronomy (SKA)

Ligand-protein docking studies of potential HIV-1 drug compounds using the algorighm FlexX

Abstract Four compounds are docked to a pentameric bundle representing the transmembrane part of the Vpu protein from HIV-1. Employing the docking algorithm FlexX, their free energy of binding is estimated leading to the conclusion that potential drug candidates need to form H-bonds either with neighbouring or with n+2 helices at the site of the serines within the bundle

XRootD and Object Store: A new paradigm

The XRootD software framework is essential for data access at WLCG sites. The WLCG community is exploring and expanding XRootD functionality. This presents a particular challenge at the RAL Tier-1 as the Echo storage service is a Ceph based Erasure Coded object store. External access to Echo uses gateway machines which run GridFTP and caching servers. Local jobs access Echo via caches on every worker node, but it is clear there are inefficiencies in the system. Remote jobs also access data via XRootD on Echo. For CMS jobs this is via the AAA service. ATLAS, who are consolidating their storage at fewer sites, are increasingly accessing job input data remotely. This paper describes the continuing work to optimise both local and remote data access by testing different caching methods

School Buildings in Greece: The Bioclimatic Challenge and a Photovoltaic Pilot Project

Greece’s School Buildings Organisation (SBO) is developing bioclimatic pilot schemes which are yielding positive results. Bioclimatic action has been one of the principal priorities of Greek school infrastructure planning since 2004. Among the activities undertaken by SBO to use renewable energy sources in school buildings is a pilot project to design and install a photovoltaic system in a secondary school in Athens.environment, school building design, energy savings, learning environment, educational buildings