The Synthesis of Keratinosomes During Epidermal Wound Healing

Employing suction-induced subepidermal blisters as a model of epidermal wound healing, the formation of keratinosomes in a differentiating epidermis has been studied. Keratinosomes appear at 24 hr after wounding. They are more fully developed at 36 hr, preceding the formation of the horny layer at 48 hr. At that time a horny layer becomes visible and keratinosomes can be seen both intra- and extra-cellularly at the granular horny cell interface