Structure and evolution of the East Sierran thrust system, east central California

This is the published version. Copyright 1984 American Geophysical Union. All Rights Reserved.A belt of arc-parallel, northeast vergent contractional deformation, the East Sierran thrust system (ESTS), crops out for ∼150 km along the east side of the Sierran continental margin arc. The ESTS is nowhere wider than ∼20 km, and it accommodated an estimated minimum of ∼9.3 km of horizontal shortening. Remarkably, it experienced repeated episodes of broadly coaxial and coaxial-planar contractional deformation beginning prior to 188 Ma and continuing past 140 Ma. We postulate that the ESTS resulted primarily from episodic underthrusting of the back arc lithosphere beneath the east edge of the Sierran arc, facilitated by a buttressing effect of the arc. As a result of this process, rocks along the east flank of the batholith, including the ESTS, were episodically shortened against the arc buttress. The ESTS experienced significant deformation during the Nevadan orogeny, indicating that contractional to transpressive deformation affiliated with this event affected the eastern wall rocks of the arc as well as its western wall rocks

Good Morning Carrie!

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Galaxy cluster outskirts: a universal entropy profile for relaxed clusters?

We fit a functional form for a universal ICM entropy profile to the scaled entropy profiles of a catalogue of X-ray galaxy cluster outskirts results, which are all relaxed cool core clusters at redshift below 0.25. We also investigate the functional form suggested by Lapi et al. and Cavaliere et al. for the behaviour of the entropy profile in the outskirts and find it to fit the data well outside 0.3r200 . We highlight the discrepancy in the entropy profile behaviour in the outskirts between observations and the numerical simulations of Burns et al., and show that the entropy profile flattening due to gas clumping calculated by Nagai & Lau is insufficient to match observations, suggesting that gas clumping alone cannot be responsible for all of the entropy profile flattening in the cluster outskirts. The entropy profiles found with Suzaku are found to be consistent with ROSAT, XMM-Newton and Planck results.Comment: 5 pages, 5 figures. Accepted for publication in MNRA

Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis.

Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by recruitment of lymphocytes and neutrophils into the lamina propria. Based on genetic evidence that attenuation of the bridging integrator 1 (Bin1) gene can limit UC pathogenicity in animals, we have explored Bin1 targeting as a therapeutic option. Early feasibility studies in the dextran sodium sulfate mouse model of experimental colitis showed that administration of a cell-penetrating Bin1 monoclonal antibody (Bin1 mAb 99D) could prevent lesion formation in the colon mucosa in part by preventing rupture of lymphoid follicles. In vivo administration of Bin1 mAb altered tight junction protein expression and cecal barrier function. Strikingly, electrophysiology studies in organ cultures showed that Bin1 mAb could elevate resistance and lowe

Global Properties of Neutral Hydrogen in Compact Groups

Compact groups of galaxies provide a unique environment to study the evolution of galaxies amid frequent gravitational encounters. These nearby groups have conditions similar to those in the earlier universe when galaxies were assembled and give us the opportunity to witness hierarchical formation in progress. To understand how the compact group environment affects galaxy evolution, we examine the gas and dust in these groups. We present new single-dish GBT neutral hydrogen (HI) observations of 30 compact groups and define a new way to quantify the group HI content as the HI-to-stellar mass ratio of the group as a whole. We compare the HI content with mid-IR indicators of star formation and optical [g-r] color to search for correlations between group gas content and star formation activity of individual group members. Quiescent galaxies tend to live in HI-poor groups, and galaxies with active star formation are more commonly found in HI-rich groups. Intriguingly, we also find "rogue" galaxies whose star formation does not correlate with group HI content. In particular, we identify three galaxies (NGC 2968 in RSCG 34, KUG 1131+202A in RSCG 42, and NGC 4613 in RSCG 64) whose mid-IR activity is discrepant with the HI. We speculate that this mismatch between mid-IR activity and HI content is a consequence of strong interactions in this environment that can strip HI from galaxies and abruptly affect star-formation. Ultimately, characterizing how and on what timescales the gas is processed in compact groups will help us understand the interstellar medium in complex, dense environments similar to the earlier Universe.Comment: Accepted to A

Economic Comparison of Alternative Burley Tobacco Harvesting Practices by Computer

The computer model CATCH (Computer Analysis of Tobacco Cutting and Housing) was developed to provide the individual tobacco producer with management information concerning alternative methods of harvesting burley tobacco. CATCH utilizes specific producer in-puts to analyze 24 alternative burley production systems and presents up to four economic rankings containing costs, equipment and labor for each system. The economic rankings aid the producer in decision making with regard to his own operation

Life course socioeconomic position and body composition in adulthood: a systematic review and narrative synthesis

INTRODUCTION: Multiple systematic reviews have investigated the relation between socioeconomic position (SEP) and body mass index (BMI) throughout the life course. However, BMI does not capture quantity and distribution of fat and muscle, which are better indicators of obesity than BMI, and have been independently linked to adverse health outcomes. Less is known about the relation between SEP and body composition, and the literature has not been reviewed. We therefore systematically reviewed the literature on the association between life course SEP and body composition in adulthood. METHODS: A protocol was registered on PROSPERO (CRD42019119937), and the review followed PRISMA guidelines. An electronic search of three databases (MEDLINE, Embase Classic + Embase and SPORTDiscus) was conducted. Original studies in the English language were included that examine the association between any recognised measure of SEP at any age and body composition (fat mass, fat-free mass, ratio and distribution) in adulthood, measured using a direct technique, i.e., not an anthropometric measure. A narrative synthesis was conducted. RESULTS: A total of 47 papers were included in the final review, none were from low-income countries (LICs). Greater advantage in childhood and adulthood was associated with lower fat levels in high-income countries (HICs). Associations in the opposite direction were found exclusively in middle-income countries (MICs). No studies in MICs reported associations for childhood SEP. For measures of lean mass, the majority of papers reported no association, or greater advantage in adulthood associated with higher lean mass, with little variation between HICs and MICs. Associations in HICs are more often observed in women than men. CONCLUSION: The results indicate that fat measures follow similar patterns to those seen for BMI, and that women in HICs are more likely to experience inequalities in both fat and lean measures. Further research in LICs and MICs is needed

Socioeconomic position and body composition in childhood in high- and middle-income countries: a systematic review and narrative synthesis

BACKGROUND: The relation between socioeconomic position (SEP) and obesity measured by body mass index (BMI), a measure of weight for height, has been extensively reviewed in children, showing consistent associations between disadvantaged SEP and higher BMI in high-income countries (HICs) and lower BMI in middle-income countries (MICs). Fat mass (FM), a more accurate measure of adiposity, and fat-free mass (FFM) are not captured by BMI, but have been shown to track from childhood to adulthood, and be important for cardiovascular health and functional outcomes in later life. It is not clear whether body composition is associated with SEP. We systematically reviewed the association between SEP and body composition in childhood. METHODS: A systematic review was carried out following PRISMA guidelines. The protocol was pre-registered with PROSPERO (CRD42019119937). Original studies in the English language, which examined the association between SEP and body composition in childhood, were included. An electronic search of three databases was conducted. Two independent reviewers carried out screening, data extraction and quality assessment. Due to heterogeneity in results, a narrative synthesis was conducted. Heterogeneity in findings according to SEP, sex, body composition measure and country income level was investigated. RESULTS: 50 papers were included, the majority from HICs. No papers were from low-income countries. Disadvantage in childhood was associated with greater FM and lower FFM in HICs, but with lower FM and lower FFM in MICs. When measures of FFM indexed to height were used there was no evidence of associations with SEP. In HICs, more studies reported associations between disadvantaged SEP and higher FM among girls comparative to boys. CONCLUSIONS: Inequalities in FM are evident in HICs and, in the opposite direction, in MICs and follow similar trends to inequalities for BMI. Inequalities in height are likely important in understanding inequalities in FFM

Reviews

Miscellany. . Reviewed by George Colvin. Wilkie Collins: A Critical and Biographical Study. Dorothy L. Sayers, ed. E.R. Gregory. Reviewed by J. R. Christopher. Bloodhounds of Heaven: The Detective in English Fiction from Godwin to Doyle. Ian Ousby. Reviewed by J. R. Christopher. The Dark Tower and Other Stories. C.S. Lewis, Ed. Walter Hooper. Reviewed by Nancy-Lou Patterson. The Mythology of Middle-earth. Ruth S. Noel. Reviewed by Nancy-Lou Patterson. Faeries. Brian Froud and Alan Lee. Reviewed by Robert S. Ellwood Jr.. Eschatus. Bruce Pennington. Reviewed by Robert S. Ellwood Jr.. The Lord of the Rings. Ralph Bakshi, director; Saul Zaentz, producer. Reviewed by Steven C. Walker. The Lord of the Rings. Ralph Bakshi, director; Saul Zaentz, producer. Reviewed by Dale Ziegler