A Direct Asymmetric Synthesis of Juglomycin A

Juglomycin A has been synthesized in four steps from 5-methoxy-1-naphthol

Hydrogen atom abstraction reactions in organic synthesis. A formal total synthesis of racemic podophyllotoxin

The key step in a synthesis of 1 was a tandem photoenolization/Diels-Alder reaction to produce 11. Hydrolysis of the acetal and ester followed by oxidation afforded 15, an advanced intermediate in the Meyers synthesis of 1

1,5- and 1,9-Hydrogen atom abstractions. Photochemical strategies for radical cyclizations

0.1 mM in dichloromethane. *The source phase, Aq I, contained a 1:l:l ratio of AMP, CMP, and GMP at a 10 mM concentration in each. The initial pH was adjusted by the careful addition of NaOH(aq). ‘Transport experiments were performed in a manner similar to those reported in refs 5 and 7. Values reported are the average of three independent measurements; estimated error \u3c5%. “Not determined. eControl experiment using 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin (0.1 mM) as the putative carrier