Advanced Ceramics Sector - An Industry of the Future:Sector Profile for the Midlands (UK) – 2021

This sector profile evidences demand for the rapid expansion of advanced ceramics, and the Midlands is well positioned to grow and create jobs in this industry.This report was commissioned by the Midlands Industrial Ceramics Group (MICG) (an academic and industrial consortium) in partnership with the Midlands Engine Observatory. . Its purpose is to raise awareness of the importance of advanced ceramics to UK industry and highlight the opportunities for growth in the Midlands.<br/

Advanced Ceramics Sector - An Industry of the Future:Sector Profile for the Midlands (UK) – 2021

This sector profile evidences demand for the rapid expansion of advanced ceramics, and the Midlands is well positioned to grow and create jobs in this industry.This report was commissioned by the Midlands Industrial Ceramics Group (MICG) (an academic and industrial consortium) in partnership with the Midlands Engine Observatory. . Its purpose is to raise awareness of the importance of advanced ceramics to UK industry and highlight the opportunities for growth in the Midlands.<br/

Identifying infection in chronic wounds in a community setting: a systematic review of diagnostic test accuracy studies

To determine the diagnostic accuracy of different methods currently available to identify infection in chronic wounds applicable to adult patients in a community setting. Systematic review of diagnostic test accuracy studies. Two authors independently completed screening, data extraction and quality and bias assessments (QUADAS2). Eligible studies compared a method (index test) for detecting infection (diagnosis of interest) with microscopy and culture of either deep tissue biopsy or wound swab (reference test) in adult patients with wounds of >4 weeks duration (participants). The results were synthesized narratively. We systematically searched CINAHL, Embase and Medline from 2011 to April 2022. Four studies were included, all recruiting from secondary care wound clinics. Two studies assessed the diagnostic accuracy of Moleculight i:X, a bacterial fluorescence imaging device against deep tissue biopsy culture. One study assessed the diagnostic accuracy of the elevation of various enzymes detected in wound fluid against wound swab microscopy of culture. One study assessed the diagnostic accuracy of bacterial protease activity against wound swab microscopy and culture. Sensitivities of these methods ranged from 50 to 75% and specificities from 47 to 100%. Only a small number of studies were included in this systematic review due to our strict inclusion criteria. We have not identified any methods for diagnosing infection in chronic wounds with either a sufficient quality of evidence to recommend their use in community settings at present. Further research is needed to develop and evaluate appropriate diagnostics for this purpose. This study highlights the paucity of research into wound diagnostics in a community setting and should prompt further research in this area. Accurate diagnostic tests have the potential to improve community-based wound care by optimizing antibiotic use and potentially improving healing time. PRISMA-DTA checklist. The PPI group for the NIHR Community Healthcare MIC were supportive of this topic of work

Commercialisation: Bridging the University-Industry Gap

The Industrial Strategy Green Paper (2017) highlighted that whilst the UK ranks first in many key global measures of research quality; in terms of intellectual property income generated against research resources and the number of successful spin-off companies the UK performs far behind US institutions. This paper investigates this long-term, systemic problem of the UK university-industry gap which limits the adoption and diffusion of new technologies

Commercialisation: Bridging the University-Industry Gap

The Industrial Strategy Green Paper (2017) highlighted that whilst the UK ranks first in many key global measures of research quality; in terms of intellectual property income generated against research resources and the number of successful spin-off companies the UK performs far behind US institutions. This paper investigates this long-term, systemic problem of the UK university-industry gap which limits the adoption and diffusion of new technologies

Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region

Aim: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. Patients &amp; methods: RNA from biopsy punch samples of resected tumor tissue was analyzed via RNA sequencing. RT-qPCR was used to determine PDE4D7 score. Results: Numerous genomic sequences within the PDE4D coding region on Chr5q12 revealed similar mRNA expression profiles to PDE4D7. PART1 had a significantly similar expression pattern to PDE4D7 across samples, correlating with disease progression. However, many other genes also exhibited matched expression to PDE4D7, including miRNAs and lncRNAs. Conclusion: These novel PDE4D7-associated genes, many of which are previously uncharacterized in cancer, represent putative PCa biomarkers and could have mechanistic roles in PCa progression

The enigmatic helicase DHX9 and its association with the hallmarks of cancer

Much interest has been expended lately in characterizing the association between DExH-Box helicase 9 (DHX9) dysregulation and malignant development, however, the enigmatic nature of DHX9 has caused conflict as to whether it regularly functions as an oncogene or tumor suppressor. The impact of DHX9 on malignancy appears to be cell-type specific, dependent upon the availability of binding partners and activation of inter-connected signaling pathways. Realization of DHX9’s pivotal role in the development of several hallmarks of cancer has boosted the enzyme's potential as a cancer biomarker and therapeutic target, opening up novel avenues for exploring DHX9 in precision medicine applications. Our review discusses the ascribed functions of DHX9 in cancer, explores its enigmatic nature and potential as an antineoplastic target