Gene Expression Signatures of Radiation Response Are Specific, Durable and Accurate in Mice and Humans

Background: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. Methods and Findings: We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation, and to determine the specificity of the PB signature of radiation versus other genotoxic stresses. Neither genotype differences nor the time of PB sampling caused any lessening of the accuracy of PB signatures to predict radiation exposure, but sex difference did influence the accuracy of the prediction of radiation exposure at the lowest level (50 cGy). A PB signature of sepsis was also generated and both the PB signature of radiation and the PB signature of sepsis were found to be 100 % specific at distinguishing irradiated from septic animals. We also identified human PB signatures of radiation exposure and chemotherapy treatment which distinguished irradiated patients and chemotherapy-treated individuals within a heterogeneous population with accuracies of 90 % and 81%, respectively. Conclusions: We conclude that PB gene expression profiles can be identified in mice and humans that are accurate i

Formación del profesorado tradición. Teoría y práctica

Estudio sobre la formación del profesorado que en las últimas décadas ha experimentado unos cambios notables. Los diferentes autores del presente libro se ocupan de los modelos de educación de profesores, situándolos dentro de temas más amplios como son las limitaciones culturales, las estructuras económicas y la transformación social. Las categorías de enseñanza, aprendizaje y competencia se incorporan a las cuestiones de trabajo, ideología, poder y diferencia de sexos, y las exigencias de profesionalidad en la enseñanza se definen como una dinámica de transformación social.ValenciaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5; 28014 Madrid; Tel. +34917748000; [email protected]