Three-Year Follow-Up of Results of Intraocular Lens Fixation in Patients with Retinitis Pigmentosa

This is a retrospective, consecutive, noncomparative case series of 6 eyes of 5 retinitis pigmentosa (RP) patients who had undergone pars plana vitrectomy (PPV) and intraocular lens (IOL) implantation. The aim of this case series was to report the long-term outcomes of PPV with IOL implantation in patients with RP). The surgical procedures, visual function, refractive error, corneal endothelial cell density, intraocular pressure, and retinal morphology were evaluated before and 3 years after the surgery. Six eyes of 5 RP patients that had undergone PPV and IOL implantation with or without suturing for lens dislocation were studied. The visual acuity was maintained or improved at 3 years after surgery in all 6 eyes. No intraoperative complications occurred in any of the cases. The mean deviation of the Humphrey Field Analyzer 10–2 program and the retinal morphology evaluated by optical coherence tomography did not show any abnormal changes before and after surgery. In two eyes, the postoperative refractive error was more myopic than the attempted refractive error. In conclusion, PPV with IOL implantation can be performed safely in RP patients, and the long-term visual acuity can be maintained

Concise Synthesis of Isocoumarins through Rh-Catalyzed Direct Vinylene Annulation: Scope and Mechanistic Insight

Transition-metal-catalyzed activation of inert C–H bonds and subsequent C–C bond formation have emerged as pow-erful synthetic tools for the synthesis of elaborate cyclic molecules. In this report, we introduce an efficient synthetic method of 3,4-unsubstituted isocoumarins adopting an electron deficient CpERh complex as the catalyst. The use of vinylene carbonate as a vinylene transfer reagent enables the direct construction of isocoumarins from readily available benzoic acids, without any external oxidants as well as bases. The reaction mechanism is evaluated by computational analysis to find an unprecedented “rhodium shift” event within the catalytic cycle.Mihara G., Ghosh K., Nishii Y., et al. Concise Synthesis of Isocoumarins through Rh-Catalyzed Direct Vinylene Annulation: Scope and Mechanistic Insight. Organic Letters. 22(14), 5706-5711, (2020), 17 July 2020; ©2020 American Chemical Society. https://doi.org/10.1021/acs.orglett.0c02112

Rhodium-catalyzed annulative coupling of isothiazoles with alkynes through n-s bond cleavage

A Rh(III)-catalyzed annulative coupling of 3,5-diarylisothiazoles and alkynes is reported. The N–S bond in the isothi-azole ring acts as an internal oxidant to regenerate the Rh(III) species in combination with an external Cu(II) oxidant, and the corre-sponding 1:2 coupling products are obtained. The remarkable difference in the reaction outcome between isothiazoles and the relevant isoxazoles has been investigated by DFT calculations, revealing that the relative stability of the enolate intermediates dictates the product selectivity.Mihara G., Noguchi T., Nishii Y., et al. Rhodium-catalyzed annulative coupling of isothiazoles with alkynes through n-s bond cleavage. Organic Letters. 22(2), 661-665, (2020), 17 January 2020; ©2020 American Chemical Society. https://doi.org/10.1021/acs.orglett.9b04437

CHOROIDAL STRUCTURE IN RP

Purpose: To investigate the choroidal structures in the enhanced depth imaging optical coherence tomographic images in eyes with retinitis pigmentosa (RP) and to determine correlations between the choroidal structures and visual functions. Methods: The enhanced depth imaging optical coherence tomographic images of 100 eyes with typical RP and 60 age-, sex-, and axial length–matched normal eyes were binarized using ImageJ. The cross-sectional luminal and stromal areas of the inner and outer subfoveal choroid of 1,500-µm width were measured. The inner choroid included the choriocapillaris and medium vessel layer, and the outer choroid included the larger vessel layer. Results: In the inner choroid, the luminal area and the ratio of luminal/total choroidal area (L/C ratio) were significantly smaller in RP than in controls (P = 0.010, P < 0.001, respectively), whereas the stromal area was not significantly different (P = 0.114). The inner choroidal L/C ratio was significantly correlated with the best-corrected visual acuity, mean deviation, foveal sensitivity, width of the ellipsoid zone, and central foveal thickness in RP after adjusting for the axial length, age, and sex (all P < 0.005). Conclusion: The significant correlations between the inner choroidal structures and the visual functions and retinal structures indicate that the choroidal structures are altered in association with the progression of RP

The Response of Blood Pressure of Men at Work to Humid Heat

The present paper described the response of blood pressure of men at work to humid heat for the purpose of determining the permissible limit of environmental heat. From the practical viewpoint of industrial health, the upper permissible limit of humid heat seemed to be 30°-31°C wet bulb temperature and yet around 90°F effective temperature

The Response of Blood Pressure in the Sitting Position to Humid Heat

The experimental study was designed to elucidate the response of blood pressure in the sitting position to humid heat for the purpose of determining the permissible limit of environmental heat. The upper permissible limit of humid heat seemed to be around 33°C wet bulb and yet around 95°F effective temperature

The Response of Blood Pressure to Humid Heat

The experimental study was conducted to throw light on the response of blood pressure of men to humid heat and to determine the permissible limits of environmental heat. The physiological disequilibrium seemed to be imminent sooner or later in the exposure to the humid heat of 95° F effective temperature (33-34°C wet bulb temperature) or more. Therefore, the permissible upper limits of environmental heat seemed to be around 95°F effective temperature

カイヨウ カンソク センヨウセン ニヨル ナンキョクカイ ノ タイキ エアロゾル カンソク

南極海における大気エアロゾル粒子の粒径分布やイオン成分濃度,先駆ガス濃度の時空間分布を調べるために,「白鳳丸」や「タンガロア」,「海鷹丸」による船上観測をおこなった.海況の穏やかな南極海での観測では,直径0.1 μm以上の既存エアロゾル粒子数濃度が著しく低い条件下で,高濃度の核生成モード粒子(直径<20 nm)を観測することがあった.逆に,既存のエアロゾル粒子数濃度が高い場合には,核生成モード粒子数濃度の増加は見られなかった.2005年1月に「海鷹丸」で観測したリュツォ・ホルム湾洋上のエアロゾル粒子中主要イオン濃度は,昭和基地で1月に観測される平均的な濃度とほぼ同じであった.「海鷹丸」と昭和基地との同時観測の結果,短時間に凝縮核数濃度が高くなるイベントの場合には,核生成モードやエイトケンモード粒子の粒径分布は両者で大きく異なっていた.To investigate spatial and temporal variation of number-size distribution of atmospheric aerosol particles in the Antarctic Ocean, atmospheric observations were conducted on research vessels: Hakuho-maru, Tangaroa, and Umitaka-maru. Concentrations of ionic constituents in aerosols and precursor gases (SO_2 and NH_3) were also measured during the cruises. Concentrations of nucleation mode particles (<20 nm in diameter) were often high under the conditions of very low number concentrations of preexisting aerosol particles larger than 0.1 μm in diameter, when the ocean was calm. Nucleation mode particles did not appear when concentrations of preexisting aerosols were high. Major ionic concentrations of aerosols at Lutzow-Holmbukta observed by Umitaka-maru in January 2005 were almost the same as average values of those in January at Syowa Station. Especially for short-term increasing events in condensation nucleus concentration, large differences were found for number size-distributions of nucleation and Aitken mode particles between Syowa Station and Umitaka-maru in Lutzow-Holmbukta