2,540 research outputs found
Mutation analysis of P73 and TP53 in Merkel cell carcinoma
The p73 gene has been mapped to 1p36.33, a region which is frequently deleted in a wide variety of neoplasms including tumours of neuroectodermal origin. The p73 protein shows structural and functional homology to p53. For these reasons, p73 was considered as a positional and functional candidate tumour suppressor gene. Thus far, mutation analysis has provided no evidence for involvement of p73 in oligodendrogliomas, lung carcinoma, oesophageal carcinoma, prostatic carcinoma and hepatocellular carcinoma. In neuroblastoma, two mutations have been observed in a series of 140 tumours. In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines and ten MCC tumours to test potential tumour suppressor function for this gene in MCC. In view of the possible complementary functions of p73 and TP53 we also examined the status of the TP53 gene. Sequence analysis of the entire coding region of the p73 gene revealed previously reported polymorphisms in four MCCs. In one MCC tumour, a mis-sense mutation located in the NH2-terminal transactivation region of the p73 gene was found. These results show that p73, analogous to neuroblastoma, is infrequently mutated in MCC. This is also the first report in which the role of TP53 in MCC has been investigated by sequencing the entire coding region of TP53. TP53 mis-sense mutations and one non-sense mutation were detected in three of 15 examined MCCs, suggesting that TP53 mutations may play a role in the pathogenesis or progression of a subset of MCCs. Moreover, typical UVB induced C to T mutations were found in one MCC cell line thus providing further evidence for sun-exposure in the aetiology of this rare skin cancer. © 2000 Cancer Research Campaig
Measurement of the B0_s semileptonic branching ratio to an orbitally excited D_s** state, Br(B0_s -> Ds1(2536) mu nu)
In a data sample of approximately 1.3 fb-1 collected with the D0 detector
between 2002 and 2006, the orbitally excited charm state D_s1(2536) has been
observed with a measured mass of 2535.7 +/- 0.6 (stat) +/- 0.5 (syst) MeV via
the decay mode B0_s -> D_s1(2536) mu nu X. A first measurement is made of the
branching ratio product Br(b(bar) -> D_s1(2536) mu nu X).Br(D_s1(2536)->D*
K0_S). Assuming that D_s1(2536) production in semileptonic decay is entirely
from B0_s, an extraction of the semileptonic branching ratio Br(B0_s ->
D_s1(2536) mu nu X) is made.Comment: 7 pages, 2 figures, LaTeX, version with minor changes as accepted by
Phys. Rev. Let
Measurement of the Lifetime Difference in the B_s^0 System
We present a study of the decay B_s^0 -> J/psi phi We obtain the CP-odd
fraction in the final state at time zero, R_perp = 0.16 +/- 0.10 (stat) +/-
0.02 (syst), the average lifetime of the (B_s, B_sbar) system, tau (B_s^0)
=1.39^{+0.13}_{-0.16} (stat) ^{+0.01}_{-0.02} (syst) ps, and the relative width
difference between the heavy and light mass eigenstates, Delta Gamma/Gamma =
(Gamma_L - Gamma_H)/Gamma =0.24^{+0.28}_{-0.38} (stat) ^{+0.03}_{-0.04} (syst).
With the additional constraint from the world average of the B_s^0$lifetime
measurements using semileptonic decays, we find tau (B_s^0)= 1.39 +/- 0.06 ~ps
and Delta Gamma/\Gamma = 0.25^{+0.14}_{-0.15}. For the ratio of the B_s^0 and
B^0 lifetimes we obtain tau(B_s^0)/tau(B^0)} = 0.91 +/- 0.09 (stat) +/- 0.003
(syst).Comment: submitted to Phys. Rev. Lett. FERMILAB-PUB-05-324-
Search for right-handed W bosons in top quark decay
We present a measurement of the fraction f+ of right-handed W bosons produced
in top quark decays, based on a candidate sample of events in the
lepton+jets decay mode. These data correspond to an integrated luminosity of
230pb^-1, collected by the DO detector at the Fermilab Tevatron
Collider at sqrt(s)=1.96 TeV. We use a constrained fit to reconstruct the
kinematics of the and decay products, which allows for the
measurement of the leptonic decay angle for each event. By comparing
the distribution from the data with those for the expected
background and signal for various values of f+, we find
f+=0.00+-0.13(stat)+-0.07(syst). This measurement is consistent with the
standard model prediction of f+=3.6x10^-4.Comment: Submitted to Physical Review D Rapid Communications 7 pages, 3
figure
Measurement of the lifetime of the B_c meson in the semileptonic decay channel
Using approximately 1.3 fb-1 of data collected by the D0 detector between
2002 and 2006, we measure the lifetime of the B_c meson in the B_c -> J/psi mu
nu X final state. A simultaneous unbinned likelihood fit to the J/\psi+mu
invariant mass and lifetime distributions yields a signal of 881 +/- 80 (stat)
candidates and a lifetime measurement of \tau(B_c) = 0.448 +0.038 -0.036 (stat)
+/- 0.032 (syst) ps.Comment: 7 pages, 2 figures, submitted to Phys. Rev. Let
Measurement of the electron charge asymmetry in ppbar->W+X->enu+X events at sqrt{s}=1.96 TeV
We present a measurement of the electron charge asymmetry in
ppbar->W+X->enu+X events at a center of mass energy of 1.96 TeV using 0.75 fb-1
of data collected with the D0 detector at the Fermilab Tevatron Collider. The
asymmetry is measured as a function of the electron transverse momentum and
pseudorapidity in the interval (-3.2, 3.2) and is compared with expectations
from next-to-leading order calculations in perturbative quantum chromodynamics.
These measurements will allow more accurate determinations of the proton parton
distribution functions.Comment: 7 pages, 3 figures, Fermilab-Pub-08/249-E, submitted to Phys. Rev.
Let
Measurement of the ppbar to ttbar production cross section at sqrt(s)=1.96 TeV in the fully hadronic decay channel
A measurement of the top quark pair production cross section in proton
anti-proton collisions at an interaction energy of sqrt(s)=1.96 TeV is
presented. This analysis uses 405 pb-1 of data collected with the D0 detector
at the Fermilab Tevatron Collider. Fully hadronic ttbar decays with final
states of six or more jets are separated from the multijet background using
secondary vertex tagging and a neural network. The ttbar cross section is
measured as sigma(ttbar)=4.5 -1.9 +2.0 (stat) -1.1 +1.4 (syst) +/- 0.3 (lumi)
pb for a top quark mass of m(t) = 175 GeV/c^2.Comment: 10 pages, 10 figures, submitted to Phys. Rev.
Search for R-parity violating supersymmetry via the LLE couplings lambda_{121}, lambda_{122} or lambda_{133} in ppbar collisions at sqrt(s)=1.96 TeV
A search for gaugino pair production with a trilepton signature in the
framework of R-parity violating supersymmetry via the couplings lambda_121,
lambda_122, or lambda_133 is presented. The data, corresponding to an
integrated luminosity of L~360/pb, were collected from April 2002 to August
2004 with the D0 detector at the Fermilab Tevatron Collider, at a
center-of-mass energy of sqrt(s)=1.96 TeV. This analysis considers final states
with three charged leptons with the flavor combinations eel, mumul, and eetau
(l=e or mu). No evidence for supersymmetry is found and limits at the 95%
confidence level are set on the gaugino pair production cross section and lower
bounds on the masses of the lightest neutralino and chargino are derived in two
supersymmetric models.Comment: 9 pages, 4 figures (fig2 includes 3 subfigures
Relative rates of B meson decays into psi(2S) and J/psi mesons
We report on a study of the relative rates of B meson decays into psi(2S) and
J/psi mesons using 1.3 fb^-1 of pbar p collisions at sqrt(s) = 1.96 TeV
recorded by the D0 detector operating at the Fermilab Tevatron Collider. We
observe the channels B^0_s -> psi(2S)phi, B^0_s -> J/psi phi, B^+/- -> psi(2S)
K^+/-, and B^+/- -> J/psi K^+/- and we measure the relative branching fractions
for these channels to be B(B^0_s -> psi(2S)phi)/B(B^0_s -> J/psi phi) = 0.55
+/- 0.11 (stat) +/- 0.07 (syst) +/- 0.06 (B), B(B^+/- -> psi(2S) K^+/-)/B(B^+/-
-> J/psi K^+/-) = 0.65 +/- 0.04 (stat) +/- 0.03 (syst) +/- 0.07 (B) where the
final error corresponds to the uncertainty in the J/psi and psi(2S) branching
ratio into two muons.Comment: Published in Phys. Rev. D - Rapid Communicatio
Search for Neutral Higgs Bosons Decaying to Tau Pairs in p-pbar Collisions at sqrt(s) = 1.96 TeV
A search for the production of neutral Higgs bosons Phi decaying into
tau^+tau^- final states in p-pbar collisions at a center-of-mass energy of 1.96
TeV is presented. The data, corresponding to an integrated luminosity of up to
348 pb^-1, were collected by the D0 experiment at the Fermilab Tevatron
Collider. Since no excess compared to the expectation from standard model
processes is found, limits on the production cross section times branching
ratio are set. The results are combined with those obtained from the D0 search
for Phi b(b) to b-bbar-b(bbar) and are interpreted in the minimal
supersymmetric standard model.Comment: Version accpeted by Phys. Rev. Lett. (minor changes
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