Global timing: a conceptual framework to investigate the neural basis of rhythm perception in humans and non-human species

Timing cues are an essential feature of music. To understand how the brain gives rise to our experience of music we must appreciate how acoustical temporal patterns are integrated over the range of several seconds in order to extract global timing. In music perception, global timing comprises three distinct but often interacting percepts: temporal grouping, beat, and tempo. What directions may we take to further elucidate where and how the global timing of music is processed in the brain? The present perspective addresses this question and describes our current understanding of the neural basis of global timing perception

Predicting Net Joint Moments During a Weightlifting Exercise with a Neural Network Model

The purpose of this study was to develop and train a Neural Network (NN) that uses barbell mass and motions to predict hip, knee, and ankle Net Joint Moments (NJM) during a weightlifting exercise. Seven weightlifters performed two cleans at 85% of their competition maximum while ground reaction forces and 3-D motion data were recorded. An inverse dynamics procedure was used to calculate hip, knee, and ankle NJM. Vertical and horizontal barbell motion data were extracted and, along with barbell mass, used as inputs to a NN. The NN was then trained to model the association between the mass and kinematics of the barbell and the calculated NJM for six weightlifters, the data from the remaining weightlifter was then used to test the performance of the NN – this was repeated 7 times with a k-fold cross-validation procedure to assess the NN accuracy. Joint-specific predictions of NJM produced coefficients of determination (r2) that ranged from 0.79 to 0.95, and the percent difference between NN-predicted and inverse dynamics calculated peak NJM ranged between 5% and 16%. The NN was thus able to predict the spatiotemporal patterns and discrete peaks of the three NJM with reasonable accuracy, which suggests that it is feasible to predict lower extremity NJM from the mass and kinematics of the barbell. Future work is needed to determine whether combining a NN model with low cost technology (e.g., digital video and free digitising software) can also be used to predict NJM of weightlifters during field-testing situations, such as practice and competition, with comparable accuracy

Biomechanical Determinants of the Reactive Strength Index During Drop Jumps

The Reactive Strength Index (RSI) is often used to quantify drop-jump (DJ) performance; however, not much is known about its biomechanical determinants. The purpose of this study was to investigate the correlations between the RSI and several biomechanical variables calculated from DJ performed with different initial drop heights. Twelve male NCAA Division I basketball players performed DJs from drop heights of 30, 45, and 60 cm. Force plates were used to calculate DJ performance parameters (ie, DJ height, contact time, and RSI) and DJ biomechanical variables (ie, vertical stiffness and eccentric/concentric energetics). Regression analyses were used to assess the correlations between variables at each drop height, and ANOVAs were used to assess the differences of all variables across drop heights. Follow-up analyses used 2 neural networks to determine if DJ performance and biomechanical data could accurately classify DJ trials by drop-height condition. Vertical-stiffness values were significantly correlated with RSI at each height but did not change across drop heights. Surprisingly, the RSI and other DJ parameters also did not vary across drop height, which resulted in the inability of these variables to accurately classify DJ trials. Given that vertical stiffness did not change across drop height and was highly correlated with RSI at each height, the RSI appears to reflect biomechanical behavior related to vertical stiffness during DJ. However, the inability of the RSI to accurately classify drop-height condition questions the use of RSI profiles established from DJs from different heights

Structural Characteristics of ACuCl3 Salts

The coordination geometries and the electronic structures found in trichlorocuprates(II) are reviewed. Trichlorocuprates occur in two types: dimers and chains. The crystal chemistry of both types is discussed. A simple electrostatic argument, charge compensation, allows the prediction of the overall structure. Interest· in the former class is focused on the different ways of dimer stacking, and on low-dimensional physics in the latter

Structural Characteristics of ACuCl3 Salts

The coordination geometries and the electronic structures found in trichlorocuprates(II) are reviewed. Trichlorocuprates occur in two types: dimers and chains. The crystal chemistry of both types is discussed. A simple electrostatic argument, charge compensation, allows the prediction of the overall structure. Interest· in the former class is focused on the different ways of dimer stacking, and on low-dimensional physics in the latter

Influence of Rhythmic Grouping on Duration Perception: A Novel Auditory Illusion

This study investigated a potential auditory illusion in duration perception induced by rhythmic temporal contexts. Listeners with or without musical training performed a duration discrimination task for a silent period in a rhythmic auditory sequence. The critical temporal interval was presented either within a perceptual group or between two perceptual groups. We report the just-noticeable difference (difference limen, DL) for temporal intervals and the point of subjective equality (PSE) derived from individual psychometric functions based on performance of a two-alternative forced choice task. In musically untrained individuals, equal temporal intervals were perceived as significantly longer when presented between perceptual groups than within a perceptual group (109.25% versus 102.5% of the standard duration). Only the perceived duration of the between-group interval was significantly longer than its objective duration. Musically trained individuals did not show this effect. However, in both musically trained and untrained individuals, the relative difference limens for discriminating the comparison interval from the standard interval were larger in the between-groups condition than in the within-group condition (7.3% vs. 5.6% of the standard duration). Thus, rhythmic grouping affected sensitivity to duration changes in all listeners, with duration differences being harder to detect at boundaries of rhythm groups than within rhythm groups. Our results show for the first time that temporal Gestalt induces auditory duration illusions in typical listeners, but that musical experts are not susceptible to this effect of rhythmic grouping.Ellison Medical FoundationNational Science Foundation (U.S.) (PA00P1_131448/1)McGovern Institute for Brain Research at MI

Mechanical Demands of the Hang Power Clean and Jump Shrug: A Joint-level Perspective

The purpose of this study was to investigate the joint- and load-dependent changes in the mechanical demands of the lower extremity joints during the hang power clean (HPC) and the jump shrug (JS). Fifteen male lacrosse players were recruited from an NCAA DI team, and completed three sets of the HPC and JS at 30%, 50%, and 70% of their HPC 1-Repetition Maximum (1-RM HPC) in a counterbalanced and randomized order. Motion analysis and force plate technology were used to calculate the positive work, propulsive phase duration, and peak concentric power at the hip, knee, and ankle joints. Separate three-way analysis of variances were used to determine the interaction and main effects of joint, load, and lift type on the three dependent variables. The results indicated that the mechanics during the HPC and JS exhibit joint-, load-, and lift-dependent behavior. When averaged across joints, the positive work during both lifts increased progressively with external load, but was greater during the JS at 30% and 50% of 1-RM HPC than during the HPC. The JS was also characterized by greater hip and knee work when averaged across loads. The joint-averaged propulsive phase duration was lower at 30% than at 50% and 70% of 1-RM HPC for both lifts. Furthermore, the load-averaged propulsive phase duration was greater for the hip than the knee and ankle joint. The jointaveraged peak concentric power was the greatest at 70% of 1-RM for the HPC and at 30% to 50% of 1-RM for the JS. In addition, the joint-averaged peak concentric power of the JS was greater than that of the HPC. Furthermore, the load-averaged peak knee and ankle concentric joint powers were greater during the execution of the JS than the HPC. However, the loadaveraged power of all joints differed only during the HPC, but was similar between the hip and knee joints for the JS. Collectively, these results indicate that compared to the HPC the JS is characterized by greater hip and knee positive joint work, and greater knee and ankle peak concentric joint power, especially if performed at 30 and 50% of 1-RM HPC. This study provides important novel information about the mechanical demands of two commonly used exercises and should be considered in the design of resistance training programs that aim to improve the explosiveness of the lower extremity joints

Time-stepping beyond CFL: a locally one-dimensional scheme for acoustic wave propagation

In this abstract, we present a case study in the application of a time-stepping method, unconstrained by the CFL condition, for computational acoustic wave propagation in the context of full waveform inversion. The numerical scheme is a locally one-dimensional (LOD) variant of alternating dimension implicit (ADI) method. The LOD method has a maximum time step that is restricted only by the Nyquist sampling rate. The advantage over traditional explicit time-stepping methods occurs in the presence of high contrast media, low frequencies, and steep, narrow perfectly matched layers (PML). The main technical point of the note, from a numerical analysis perspective, is that the LOD scheme is adapted to the presence of a PML. A complexity study is presented and an application to full waveform inversion is shown.National Science Foundation (U.S.); Alfred P. Sloan Foundatio

Treatment of Advanced Emphysema with Emphysematous Lung Sealant (AeriSeal (R))

Background: This report summarizes initial tests of an emphysematous lung synthetic polymer sealant (ELS) designed to reduce lung volume in patients with advanced emphysema. Objectives: The primary study objective was to define a therapeutic strategy to optimize treatment safety and effectiveness. Methods: ELS therapy was administered bronchoscopically to 25 patients with heterogeneous emphysema in an open-label, noncontrolled study at 6 centers in Germany. Treatment was performed initially at 2-4 subsegments. After 12 weeks, patients were eligible for repeat therapy to a total of 6 sites. Safety and efficacy were assessed after 6 months. Responses were evaluated in terms of changes from baseline in lung physiology, functional capacity, and health-related quality of life. Follow-up is available for 21 of 25 patients. Results: Treatment was well tolerated. There were no treatment-related deaths (i.e. within 90 days of treatment), and an acceptable short-and long-term safety profile. Physiological and clinical benefits were observed at 24 weeks. Efficacy responses were better among Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage III patients {[}n = 14; change in residual volume/total lung capacity (Delta RV/TLC) = -7.4 +/- 10.3%; Delta forced expiratory volume in 1 s (Delta FEV(1)) = +15.9 +/- 22.6%; change in forced vital capacity (Delta FVC) = +24.1 +/- 22.7%; change in carbon monoxide lung diffusion capacity (Delta DLCO) = +19.3 +/- 34.8%; change in 6-min walk test (Delta 6MWD) = +28.7 +/- 59.6 m; change in Medical Research Council Dyspnea (Delta MRCD) score = -1.0 +/- 1.04 units; change in St. George's Respiratory Questionnaire (Delta SGRQ) score = -9.9 +/- 15.3 units] than for GOLD stage IV patients (n = 7; Delta RV/TLC = -0.5 +/- 6.4%; Delta FEV 1 = +2.3 +/- 12.3%; Delta FVC = +2.6 +/- 21.1%; Delta DLCO = -2.8 +/- 17.2%; Delta 6MWD = +28.3 +/- 58.4 m; Delta MRCD = 0.3 +/- 0.81 units; Delta SGRQ = -6.7 +/- 7.0 units). Conclusions: ELS therapy shows promise for treating patients with advanced heterogeneous emphysema. Additional studies to assess responses in a larger cohort with a longer follow-up are warranted. Copyright (C) 2011 S. Karger AG, Base

Coherent vs incoherent interlayer transport in layered metals

The magnetic-field, temperature, and angular dependence of the interlayer magnetoresistance of two different quasi-two-dimensional (2D) organic superconductors is reported. For $\kappa$-(BEDT-TTF)$_2$I$_3$ we find a well-resolved peak in the angle-dependent magnetoresistance at $\Theta = 90^\circ$ (field parallel to the layers). This clear-cut proof for the coherent nature of the interlayer transport is absent for $\beta$''-(BEDT-TTF)$_2$SF$_5$CH$_2$CF$_2$SO$_3$. This and the non-metallic behavior of the magnetoresistance suggest an incoherent quasiparticle motion for the latter 2D metal.Comment: 4 pages, 4 figures. Phys. Rev. B, in pres