Methods and Tools for Battery-free Wireless Networks

Embedding small wireless sensors into the environment allows for monitoring physical processes with high spatio-temporal resolutions. Today, these devices are equipped with a battery to supply them with power. Despite technological advances, the high maintenance cost and environmental impact of batteries prevent the widespread adoption of wireless sensors. Battery-free devices that store energy harvested from light, vibrations, and other ambient sources in a capacitor promise to overcome the drawbacks of (rechargeable) batteries, such as bulkiness, wear-out and toxicity. Because of low energy input and low storage capacity, battery-free devices operate intermittently; they are forced to remain inactive for most of the time charging their capacitor before being able to operate for a short time. While it is known how to deal with intermittency on a single device, the coordination and communication among groups of multiple battery-free devices remain largely unexplored. For the first time, the present thesis addresses this problem by proposing new methods and tools to investigate and overcome several fundamental challenges

Entwicklung eines mesoskopischen Modells zur Abbildung von Größeneffekten in der Kaltmassivumformung mit Methoden der FE-Simulation

With considering the microstructure, the mesoscopic model developed in this study is able to map size dependent forming behaviour to the simulation results by using finite element method. The knowledge of the local deformation behaviour enables a size-dependent design of the deformation process as well as the calculation of size-dependent process scatter.Das entwickelte mesoskopische Modell ermöglicht, unter Berücksichtigung der Gefügestruktur, die Abbildung von skalenabhängigen Effekten bei Kaltmassivumformprozessen mit Methoden der finiten Elemente Simulation. Aufgrund der genauen Kenntnis des lokalen Formänderungsverhaltens kann neben einer größenangepassten Prozessauslegung auch die Abbildung von größenabhängigen Prozessstreuungen realisiert und in der Prozessplanung berücksichtigt werden

Pilot Study on the Use of a Laser-Structured Double Diamond Electrode (DDE) for Biofilm Removal from Dental Implant Surfaces

No proper treatment option for peri-implantitis exists yet. Based on previous studies showing the in vitro effectiveness of electrochemical disinfection using boron-doped diamond electrodes, novel double diamond electrodes (DDE) were tested here. Using a ceramic carrier and a laser structuring process, a clinically applicable electrode array was manufactured. Roughened metal discs (n = 24) made from Ti-Zr alloy were exposed to the oral cavities of six volunteers for 24 h in order to generate biofilm. Then, biofilm removal was carried out either using plastic curettes and chlorhexidine digluconate or electrochemical disinfection. In addition, dental implants were contaminated with ex vivo multispecies biofilm and disinfected using DDE treatment. Bacterial growth and the formation of biofilm polymer were determined as outcome measures. Chemo-mechanical treatment could not eliminate bacteria from roughened surfaces, while in most cases, a massive reduction of bacteria and biofilm polymer was observed following DDE treatment. Electrochemical disinfection was charge- and time-dependent and could also not reach complete disinfection in all instances. Implant threads had no negative effect on DDE treatment. Bacteria exhibit varying resistance to electrochemical disinfection with Bacillus subtilis, Neisseria sp., Rothia mucilaginosa, Staphylococcus haemolyticus, and Streptococcus mitis surviving 5 min of DDE application at 6 V. Electrochemical disinfection is promising but requires further optimization with respect to charge quantity and application time in order to achieve disinfection without harming host tissue

Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin

Colistin (polymyxin E) is a membrane-destabilizing antibiotic used against Gram-negative bacteria. We have recently reported that the outer membrane prevents the uptake of antibacterial chlorophyllin into Gram-negative cells. In this study, we used sub-toxic concentrations of colistin to weaken this barrier for a combination treatment of Escherichia coli and Salmonella enterica serovar Typhimurium with chlorophyllin. In the presence of 0.25 µg/mL colistin, chlorophyllin was able to inactivate both bacteria strains at concentrations of 5–10 mg/L for E. coli and 0.5–1 mg/L for S. Typhimurium, which showed a higher overall susceptibility to chlorophyllin treatment. In accordance with a previous study, chlorophyllin has proven antibacterial activity both as a photosensitizer, illuminated with 12 mW/cm2, and in darkness. Our data clearly confirmed the relevance of the outer membrane in protection against xenobiotics. Combination treatment with colistin broadens chlorophyllin’s application spectrum against Gram-negatives and gives rise to the assumption that chlorophyllin together with cell membrane-destabilizing substances may become a promising approach in bacteria control. Furthermore, we demonstrated that colistin acts as a door opener even for the photodynamic inactivation of colistin-resistant (mcr-1-positive) E. coli cells by chlorophyllin, which could help us to overcome this antimicrobial resistance

A Severe Case of Tuberculosis Radiologically and Endoscopically Mimicking Colorectal Cancer with Peritoneal Carcinomatosis

Although generally rising in incidence, intestinal tuberculosis is still rare in western countries and due to unspecific manifestations mainly as ulcerations on endoscopy, diagnosis of intestinal tuberculosis is challenging. Within this report, we describe a case of severe intestinal tuberculosis radiologically and endoscopically masquerading as colorectal cancer with peritoneal carcinomatosis. Our case exemplifies that intestinal tuberculosis needs to be considered as a differential diagnosis in patients at risk and that undelayed and sensitive diagnosis of intestinal tuberculosis is of central importance for avoiding unfavorable disease outcome

Methods and Tools for Battery-free Wireless Networks

Embedding small wireless sensors into the environment allows for monitoring physical processes with high spatio-temporal resolutions. Today, these devices are equipped with a battery to supply them with power. Despite technological advances, the high maintenance cost and environmental impact of batteries prevent the widespread adoption of wireless sensors. Battery-free devices that store energy harvested from light, vibrations, and other ambient sources in a capacitor promise to overcome the drawbacks of (rechargeable) batteries, such as bulkiness, wear-out and toxicity. Because of low energy input and low storage capacity, battery-free devices operate intermittently; they are forced to remain inactive for most of the time charging their capacitor before being able to operate for a short time. While it is known how to deal with intermittency on a single device, the coordination and communication among groups of multiple battery-free devices remain largely unexplored. For the first time, the present thesis addresses this problem by proposing new methods and tools to investigate and overcome several fundamental challenges

Methods and Tools for Battery-free Wireless Networks

Embedding small wireless sensors into the environment allows for monitoring physical processes with high spatio-temporal resolutions. Today, these devices are equipped with a battery to supply them with power. Despite technological advances, the high maintenance cost and environmental impact of batteries prevent the widespread adoption of wireless sensors. Battery-free devices that store energy harvested from light, vibrations, and other ambient sources in a capacitor promise to overcome the drawbacks of (rechargeable) batteries, such as bulkiness, wear-out and toxicity. Because of low energy input and low storage capacity, battery-free devices operate intermittently; they are forced to remain inactive for most of the time charging their capacitor before being able to operate for a short time. While it is known how to deal with intermittency on a single device, the coordination and communication among groups of multiple battery-free devices remain largely unexplored. For the first time, the present thesis addresses this problem by proposing new methods and tools to investigate and overcome several fundamental challenges

Entwicklung eines mesoskopischen Modells zur Abbildung von Größeneffekten in der Kaltmassivumformung mit Methoden der FE-Simulation

Das entwickelte mesoskopische Modell ermöglicht, unter Berücksichtigung der Gefügestruktur, die Abbildung von skalenabhängigen Effekten bei Kaltmassivumformprozessen mit Methoden der finiten Elemente Simulation. Aufgrund der genauen Kenntnis des lokalen Formänderungsverhaltens kann neben einer größenangepassten Prozessauslegung auch die Abbildung von größenabhängigen Prozessstreuungen realisiert und in der Prozessplanung berücksichtigt werden.With considering the microstructure, the mesoscopic model developed in this study is able to map size dependent forming behaviour to the simulation results by using finite element method. The knowledge of the local deformation behaviour enables a size-dependent design of the deformation process as well as the calculation of size-dependent process scatter