62 research outputs found
TOPICAL AND SYSTEMIC DERMAL CARRIERS FOR PSORIASIS
Psoriasis is a non-infectious, dry, inflammatory (autoimmune) skin disorder. Treatment approaches include phototherapy, topical, oral and other systemic drug delivery. However, owing to the side effects and incomplete cure accompanying the oral administration as well as phototherapy, the topical route seemed to be more satisfactory for the medical team. Dermal treatment ensuring percutaneous penetration is now highly recommended in topical indications for psoriatic patients, which can be achieved using pharmaceutical carriers. Several carrier systems loaded with antipsoriatic drugs have demonstrated promising results, with some of them strictly being confined to the skin and others allowing for systemic involvement also. The evolution in this area will present a more useful and safer therapy by minimizing the drugs' degradation and loss, and increasing their bioavailability and effectiveness. Since patients require at least three topical applications for almost a 1-year period to gain health benefit, a reduction in the cost of the treatment will be of real value. A distinction of these carriers is made in the current review, to allow the choice of the most suitable pharmaceutical carrier for psoriatic patients requiring either local and/or systemic involvement
Le vocabulaire amoureux dans les «Tristans»
Gehanne Dominique. Le vocabulaire amoureux dans les «Tristans». In: Médiévales, n°3, 1983. Trajectoire du sens. pp. 68-75
"Approches de l'inhibition et de la catalyse de reactions bioorganiques: 1) inhibition d'enzymes d'oxydation de l'acide arachidonique; 2) catalyse d'une etape de la synthese de la vitamine C "
SIGLEINIST T 75974 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Caractéristiques cardiovasculaires des sportifs français de haut niveau
RENNES1-BU Santé (352382103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Introduction au dossier « Voltaire et la nature : un “philosophe champêtre" »
International audienc
Apologétique et fiction (Caraccioli,les lettres intéressantes du Pape Clément XIX)
La thèse a pour objet de rendre son importance historique à un best-seller de l édition française du XVIIIe siècle : les Lettres intéressantes du pape Clément XIV (Ganganelli), recueil apocryphe publié par Caraccioli en 1776, moins de deux ans après la disparition du pontife. Ces pseudo-lettres, la figure et la voix de leur auteur mises en œuvre, constituent une formidable supercherie épistolaire et une tentative apologétique novatrice. Tous les aspects du phénomène sont pris en compte : la genèse et l histoire du texte (lancement, augmentations, traductions), la réception critique et polémique du livre, le dossier constitué par Caraccioli pour sa défense, les enjeux conjoints de vérité et d autorité que cette affaire souleva. Aux confins de l épistémè classique, la lente formation d une fonction-auteur et surtout le développement des pratiques fictionnelles entraînent des mutations sensibles. D ordre globalement poétique, elles affectent plus particulièrement l esthétique, mais aussi le contenu thématique et notionnel des écrits apologétiques. On assiste ainsi à une sécularisation du discours religieux, qui subit l attrait de la fiction.This thesis aims to restore the historical importance of an eighteenth-century best-seller: the Interesting letters of Pope Clement XIV (Ganganelli), an apocryphal collection published by Caraccioli in 1776, less than two years after the pope s death. These so-called-letters, where the figure and the voice of their author are at work, constitute a remarkable epistolary deception and an innovative apologetic attempt. All the aspects of the phenomenon have been considered: the genesis and the history of the text (publication, extra letters and translations), the critical and polemical reception accorded to the book, the file Caraccioli drew up in his defence, and the issues linked both to truth and authority that this case raised. On the border of classical épistémè, the gradual creation of an authorial function and, above all, the development of fictional devices, induce noticeable transformations, poetical on the whole, which not only affect the aesthetic aspects, but also the thematic and notional content of apologetic literature. Thus we witness a secularisation of the religious discourse as expressed in fiction.NANTERRE-BU PARIS10 (920502102) / SudocSudocFranceF
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