2,970 research outputs found
Motivations and experiences of UK students studying abroad
This report summarises the findings of research aimed at improving understanding of the motivations behind the international diploma mobility of UK student
Hypertension: Why Is It Critical?
Hypertension is a common problem, particularly in older cats. Hypertension secondary to a concurrent disease is the most common form of hypertension in cats, particularly in association with chronic kidney disease or hyperthyroidism. However, idiopathic hypertension may account for up to 24% of cases. Any form of persistent hypertension risks target organ damage (TOD), therefore measurement of blood pressure is vital in at-risk cats to identify occult hypertension before TOD occurs. This article addresses when and how to perform blood pressure measurement in cats, TOD that has been documented in this species, and our evidence basis for treating hypertension
Effects of Hyperbolic Rotation in Minkowski Space on the Modeling of Plasma Accelerators in a Lorentz Boosted Frame
Laser driven plasma accelerators promise much shorter particle accelerators
but their development requires detailed simulations that challenge or exceed
current capabilities. We report the first direct simulations of stages up to 1
TeV from simulations using a Lorentz boosted calculation frame resulting in a
million times speedup, thanks to a frame boost as high as gamma=1300. Effects
of the hyperbolic rotation in Minkowski space resulting from the frame boost on
the laser propagation in the plasma is shown to be key in the mitigation of a
numerical instability that was limiting previous attempts
Associations between single nucleotide polymorphisms in the calcium sensing receptor and chronic kidney disease-mineral and bone disorder in cats
Feline chronic kidney disease (CKD) is associated with high variability in severity of CKD-mineral and bone disorder (CKD-MBD). The calcium sensing receptor (CaSR) regulates circulating parathyroid hormone (PTH) and calcium concentrations. Single nucleotide polymorphisms (SNPs) in the CaSR are associated with severity of secondary renal hyperparathyroidism and total calcium concentrations in human patients receiving haemodialysis. The objective of this study was to explore associations between polymorphisms in the feline CaSR (fCaSR) and biochemical changes observed in CKD-MBD.
Client owned cats (≥ 9 years) were retrospectively included. SNP discovery was performed in 20 cats with azotaemic CKD and normal or dysregulated calcium concentrations. Non-pedigree cats (n = 192) (125 with azotaemic CKD and 66 healthy), Persians (n = 40) and Burmese (n = 25) were genotyped for all identified SNPs using KASP. Biochemical parameters from the date of CKD diagnosis or from first visit to the clinic (healthy cats) were used. Associations between genotype and ionized calcium, total calcium, phosphate, PTH and FGF-23 were performed for non-pedigree cats using logistic regression.
Sequence alignment against the fCaSR sequence revealed eight novel exonic SNPs. KASP genotyping had high accuracy (99.6%) and a low failure rate (A was associated with logPTH concentration (adjusted for plasma creatinine concentration), with a recessive model having the best fit (G/G vs A/A-G/A, P = 0.031).
Genetic variation in the fCaSR is unlikely to explain the majority of the variability in presence and severity of CKD-MBD in cats
Cardiac output during CPR: a comparison of two methods
Simultaneous Fick and saline dilution methods were compared for measuring cardiac output during experimental cardiac arrest and resuscitation in anesthetized dogs. During cardiopulmonary resuscitation (CPR) cardiac output averaged 53 ± 30 ml/min-kg (42% of pre-arrest values). Values obtained using the Fick vs. saline methods were highly correlated (r = 0.96), and were not statistically different (t = 1.47, df = 16)
Transchest defibrillation under conditions of hypothermia
This study was conducted to determine whether or not hypothermia changes ventricular defibrillation threshold. Ventricular fibrillation was induced by electrical stimulation of the endocardium in pentobarbital anesthetized dogs, both during normothermia and hypothermia produced by circulating 8 °C water through a rubber bladder implanted in the peritoneal cavity. Defibrillation threshold was determined as the shock strength needed to defibrillate the ventricles and differing no more than 10 percent from a shock strength that failed to defibrillate. Defibrillation threshold current was stable for body temperatures ranging from 37 oC to 22 oC. Threshold energy increased linearly with decreasing temperature in keeping with the expected temperature-dependent changes in body fluid resistance. Normothermic electrical doses are probably appropriate for defibrillation of hypothermic children
Influence of interposed ventilation pressure upon artificial cardiac output during cardiopulmonary resuscitation in dogs
This study was conducted to determine the effects of high pressure interposed ventilations during cardiopulmonary resuscitation (CPR). Cardiac output was measured by a modified indicator dilution technique in eight anesthetized, intubated mongrel dogs. Positive pressure ventilations (12/min, 80% O2) were interposed after every five chest compressions (performed at 62/min) by a mechanical chest compressor (Thumper®). On repeated trials in the same animal, ventilation pressures from 10-50 cm of H2O were tested in randomized sequence, while the technique of chest compression was held constant. Arterial blood gases immediately after resuscitation were monitored. Increasing ventilation pressure had surprisingly little effect on cardiac output during CPR, although blood gases were profoundly altered. For ventilation pressures of 10, 20, 30, 40, and 50 cm of H2O, producing mean tidal volumes 23, 38, 61, 83, and 94 ml/kg; cardiac output remained nearly constant, averaging 21, 25, 23, 26, and 24 ml/min/kg. Corresponding mean post-resuscitation pH was 7.24, 7.41, 7.51, 7.56, and 7.53; PCO2 was 41, 26, 18, 16, and 15 torr. The post-resuscitation arterial oxygen tension was greater than 100 torr at all ventilation pressures except 10 cm of H2O. Interposed ventilations of pressure and volume more than adequate to prevent acidosis during CPR did not impair artificial cardiac output. If anything, cardiac output was slightly improved by more forceful ventilation
Relationship of blood pressure and flow during CPR to chest compression amplitude: Evidence for an effective compression threshold
This study was conducted to investigate the importance of the depth of chest compression in producing effective cardiopulmonary resuscitation (CPR) in animals, as indicated by cardiac output and mean arterial blood pressure. Cardiac output was measured by a modified indicator dilution technique in 8 anesthetized dogs, 6 to 12 kg body weight, during repeated 2-minute episodes of electrically induced ventricular fibrillation and CPR provided by a mechanical chest compressor and ventilator (Thumper®). Chest compression exceeding a threshold value (x0) between 1.5 and 3.0 cm was required in each animal to produce measurable cardiac output. In particular, cardiac output (CO) was linearly related to chest compression depth (x) by an expression of the form CO = a(x-x0) for x \u3e x0, and CO = 0 for x £ x0. The mean value of x0 was 2.3 cm. A similar threshold for measurable blood pressure was observed in 7 of the 8 dogs, with a mean value of 1.8 cm. For chest compression of 2.5 cm or greater, relatively modest increases in chest compression depth caused relatively large changes in cardiac output
Laminar flow of two miscible fluids in a simple network
When a fluid comprised of multiple phases or constituents flows through a
network, non-linear phenomena such as multiple stable equilibrium states and
spontaneous oscillations can occur. Such behavior has been observed or
predicted in a number of networks including the flow of blood through the
microcirculation, the flow of picoliter droplets through microfluidic devices,
the flow of magma through lava tubes, and two-phase flow in refrigeration
systems. While the existence of non-linear phenomena in a network with many
inter-connections containing fluids with complex rheology may seem
unsurprising, this paper demonstrates that even simple networks containing
Newtonian fluids in laminar flow can demonstrate multiple equilibria.
The paper describes a theoretical and experimental investigation of the
laminar flow of two miscible Newtonian fluids of different density and
viscosity through a simple network. The fluids stratify due to gravity and
remain as nearly distinct phases with some mixing occurring only by diffusion.
This fluid system has the advantage that it is easily controlled and modeled,
yet contains the key ingredients for network non-linearities. Experiments and
3D simulations are first used to explore how phases distribute at a single
T-junction. Once the phase separation at a single junction is known, a network
model is developed which predicts multiple equilibria in the simplest of
networks. The existence of multiple stable equilibria is confirmed
experimentally and a criteria for their existence is developed. The network
results are generic and could be applied to or found in different physical
systems
Bostonia. Volume 4
Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs
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