Variables Influencing the Filtration of Water through Paper

When water is filtered through paper under constant pressure, the flow rate decreases with time, even if distilled water is used as the permeating fluid. On the basis of previous literature,·possible causes of this effect were thought to be fiber swelling, the presence of microscopic bubbles in the water, electrical forces, or structures formed by water molecules and ionic impurities. Experimentation showed that there is a blocking agent present in the distilled water which causes the decrease in flow rate. These particulate agents are denser than water, and have a greater affinity for cellulose than for glass. The particulates have a positive charge associated with them, and it is possible that some amount of electrolyte may be physically or chemically bound to them. It was observed that filtration of water through ordinary laboratory filter paper can result in decreasing the conductivity of t he water. Three possible mechanisms were proposed, although on the basis of this study alone the exact nature of the conductivity reducing effect can not be determined. The electrical potential difference that may easily measured between the two side of a filter paper as water flows through it is actually a complex combination of the affects of several sources. The most important of these sources are the streaming potential and the accumulation of charged particulates

Stratosphere-troposphere separation of nitrogen dioxide columns from the TEMPO geostationary satellite instrument

Separating the stratospheric and tropospheric contributions in satellite retrievals of atmospheric NO2 column abundance is a crucial step in the interpretation and application of the satellite observations. A variety of stratosphere–troposphere separation algorithms have been developed for sun-synchronous instruments in low Earth orbit (LEO) that benefit from global coverage, including broad clean regions with negligible tropospheric NO2 compared to stratospheric NO2. These global sun-synchronous algorithms need to be evaluated and refined for forthcoming geostationary instruments focused on continental regions, which lack this global context and require hourly estimates of the stratospheric column. Here we develop and assess a spatial filtering algorithm for the upcoming TEMPO geostationary instrument that will target North America. Developments include using independent satellite observations to identify likely locations of tropospheric enhancements, using independent LEO observations for spatial context, consideration of diurnally varying partial fields of regard, and a filter based on stratospheric to tropospheric air mass factor ratios. We test the algorithm with LEO observations from the OMI instrument with an afternoon overpass, and from the GOME-2 instrument with a morning overpass. We compare our TEMPO field of regard algorithm against an identical global algorithm to investigate the penalty resulting from the limited spatial coverage in geostationary orbit, and find excellent agreement in the estimated mean daily tropospheric NO2 column densities (R2=0.999, slope=1.009 for July and R2=0.998, slope=0.999 for January). The algorithm performs well even when only small parts of the continent are observed by TEMPO. The algorithm is challenged the most by east coast morning retrievals in the wintertime (e.g., R2=0.995, slope=1.038 at 14:00 UTC). We find independent global LEO observations (corrected for time of day) provide important context near the field-of-regard edges. We also test the performance of the TEMPO algorithm without these supporting global observations. Most of the continent is unaffected (R2=0.924 and slope=0.973 for July and R2=0.996 and slope=1.008 for January), with 90 % of the pixels having differences of less than ±0.2×1015 molecules cm−2 between the TEMPO tropospheric NO2 column density and the global algorithm. For near-real-time retrieval, even a climatological estimate of the stratospheric NO2 surrounding the field of regard would improve this agreement. In general, the additional penalty of a limited field of regard from TEMPO introduces no more error than normally expected in most global stratosphere–troposphere separation algorithms. Overall, we conclude that hourly near-real-time stratosphere–troposphere separation for the retrieval of NO2 tropospheric column densities by the TEMPO geostationary instrument is both feasible and robust, regardless of the diurnally varying limited field of regard.The authors are grateful to Kelly Chance, Xiong Liu, John Houck, Peter Zoogman, and other members of the TEMPO trace gas retrieval team for their input in preparation of this paper. Work at Dalhousie University was supported by Environment and Climate Change Canada. The authors also gratefully acknowledge the free use of TEMIS NO2 data from the GOME-2 sensor provided by http://www.temis.nl, last access: 12 November 2018, and the NASA Standard Product NO2 data from OMI provided by https://disc.gsfc.nasa.gov/datasets/OMNO2_V003/summary, last access: 9 November 2018. (Environment and Climate Change Canada)https://www.atmos-meas-tech.net/11/6271/2018/Published versio

Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression.

Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in insulin signaling. Akt activation alone accounted for ~25% of the variance in GLUT4, indicating that additional sources of variance exist. The Akt and GLUT4 responses were highly reproducible within the same cell, suggesting the variance is between cells (extrinsic) and not within cells (intrinsic). Generalized mechanistic models (supported by experimental observations) demonstrated that the correlation between the steady-state levels of two measured signaling processes decreases with increasing distance from each other and that intercellular variation in protein expression (as an example of extrinsic variance) is sufficient to account for the variance in and between Akt and GLUT4. Thus, the response of a population to insulin signaling is underpinned by considerable single-cell heterogeneity that is largely driven by variance in gene/protein expression between cells

Bostonia: The Boston University Alumni Magazine. Volume 12

Founded in 1900, Bostonia magazine is Boston University’s main alumni publication

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been reported, which is indicative of negative feedback operating on acute timescales. Here, we show that Akt itself engages this negative feedback by phosphorylating insulin receptor substrate (IRS) 1 and 2 on a number of residues. Phosphorylation results in the depletion of plasma membrane-localised IRS1/2, reducing the pool available for interaction with the insulin receptor. Together these events limit plasma membrane-associated PI3K and phosphatidylinositol (3,4,5)-trisphosphate (PIP3) synthesis. We identified two Akt-dependent phosphorylation sites in IRS2 at S306 (S303 in mouse) and S577 (S573 in mouse) that are key drivers of this negative feedback. These findings establish a novel mechanism by which the kinase Akt acutely controls PIP3 abundance, through post-translational modification of the IRS scaffold

Exercise therapy in adults with serious mental illness: a systematic review and meta-analysis

Background: Individuals with serious mental illness are at a higher risk of physical ill health. Mortality rates are at least twice those of the general population with higher levels of cardiovascular disease, metabolic disease, diabetes, and respiratory illness. Although genetics may have a role in the physical health problems of these patients, lifestyle and environmental factors such as levels of smoking, obesity, poor diet, and low levels of physical activity also play a prominent part.<p></p> Objective: To conduct a systematic review and meta-analysis of randomised controlled trials comparing the effect of exercise interventions on individuals with serious mental illness.<p></p> Methods: Searches were made in Ovid MEDLINE, Embase, CINAHL, PsycINFO, Biological Abstracts on Ovid, and The Cochrane Library (January 2009, repeated January 2013) through to February 2013.<p></p> Results: Eight RCTs were identified in the systematic search. Six compared exercise versus usual care. One study assessed the effect of a cycling programme versus muscle strengthening and toning exercises. The final study compared the effect of adding specific exercise advice and motivational skills to a simple walking programme. Exercise programmes were noted by their heterogeneity in terms of the type of exercise intervention, setting, and outcome measures. The review found that exercise improved levels of exercise activity (n=13, standard mean difference [SMD] 1.81, CI 0.44 to 3.18, p = 0.01). No beneficial effect was found on negative (n = 84, SMD = -0.54, CI -1.79 to 0.71, p = 0.40) or positive symptoms of schizophrenia (n = 84, SMD = -1.66, CI -3.78 to 0.45, p = 0.12). No change was found on body mass index compared with usual care (n= 151, SMD = -0.24, CI -0.56 to 0.08, p = 0.14), or body weight (n = 77, SMD = 0.13, CI -0.32 to 0.58, p = 0.57). No beneficial effect was found on anxiety and depressive symptoms (n = 94, SMD = -0.26, CI -0.91 to 0.39, p = 0.43), or quality of life in respect of physical and mental domains. One RCT measured the effect of exercise on exercise intensity, attendance, and persistence at a programme. No significant effect was found on these measures.<p></p> Conclusions: This systematic review showed that exercise therapies can lead to a modest increase in levels of exercise activity but overall there was no noticeable change for symptoms of mental health, body mass index, and body weight.<p></p&gt

Social media and protest mobilization: evidence from the Tunisian revolution

This article explores how social media acted as a catalyst for protest mobilization during the Tunisian revolution in late 2010 and early 2011. Using evidence from protests we argue that social media acted as an important resource for popular mobilization against the Ben Ali regime. Drawing on insights from “resource mobilization theory”, we show that social media (1) allowed a “digital elite” to break the national media blackout through brokering information for mainstream media; (2) provided a basis for intergroup collaboration for a large “cycle of protest”; (3) reported event magnitudes that raised the perception of success for potential free riders, and (4) provided additional “emotional mobilization” through depicting the worst atrocities associated with the regime’s response to the protests. These findings are based on background talks with Tunisian bloggers and digital activists and a revealed preference survey conducted among a sample of Tunisian internet users (February–May 2012)

Explaining Institutional Change: Why Elected Politicians Implement Direct Democracy

In existing models of direct democratic institutions, the median voter benefits, but representative politicians are harmed since their policy choices can be overridden. This is a puzzle, since representative politicians were instrumental in creating these institutions. I build a model of direct democracy that explains why a representative might benefit from tying his or her own hands in this way. The key features are (1) that voters are uncertain about their representative's preferences; (2) that direct and representative elections are complementary ways for voters to control outcomes. The model shows that some politicians benefit from the introduction of direct democracy, since they are more likely to survive representative elections: direct democracy credibly prevents politicians from realising extreme outcomes. Historical evidence from the introduction of the initiative, referendum and recall in America broadly supports the theory, which also explains two empirical results that have puzzled scholars: legislators are trusted less, but reelected more, in US states with direct democracy. I conclude by discussing the potential for incomplete information and signaling models to improve our understanding of institutional change more generally

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns