The Mechanism and strategy of Digital Logistics Park Cross Supply Chain Collaboration based on Evolutionary Game

In order to overcome the disadvantages of go-it-alone in logistics parks, it is necessary to select appropriate horizontal collaboration strategies to promote cooperation among logistics parks. Considering a kind of horizontal collaboration cross supply chain between logistics parks under digital Cloud platform, there is a three-party composed of one Cloud platform and two logistics parks. According to the benefit function of each party, a dynamic replication equation is constructed to analyze the stability strategy of the three-party Evolutionary Game, and then a Jacobian matrix is constructed to analyze the stability of the equilibrium point of the three-party Evolutionary Game of the resource sharing strategy between logistics parks. Moreover, two gradually stable strategies (0,0,0) and (1,1,1) are formed, and the strategy is affected by the initial sharing proportion of resources between logistics parks, the risk of customer order loss and the proportion of Cloud platform subsidy. The simulation analysis shows that the higher the initial sharing proportion of resources among logistics parks, the more likely the logistics parks are to choose the horizontal collaboration strategy, and the more likely the Cloud platform are to choose the subsidy strategy; the higher the subsidy proportion, the more willing the logistics parks are to choose the horizontal collaboration strategy. Combined with the actual operation of the logistics park, it is suggested to strengthen the guiding effect of the core logistics park, strengthen the supervision and guiding ability of the Cloud platform, emphasize the risk sharing and revenue sharing among the logistics parks, and jointly promote the collaborative operation and development among the logistics parks

Effectiveness of acupuncture for breast cancer related lymphedema: protocol for a single-blind, sham-controlled, randomized, multicenter trial

Abstract Background Although various treatments for breast cancer related lymphedema exist, there is still a need for a more effective and convenient approach. Pilot studies and our clinical observations suggested that acupuncture may be a potential option. This study aims to verify the effectiveness of acupuncture on BCRL and evaluate its safety using a rigorously designed trial. Methods/Design Women who are clinically diagnosed as unilateral BCRL, with a 10% to 40% increase in volume compared to the unaffected arm, will be recruited. Following baseline assessment, participants will be randomized to either the real acupuncture group or sham-acupuncture group at a ratio of 1:1, and given a standard real acupuncture or sham-acupuncture treatment accordingly on both arms followed by the same usual care of decongestive therapy. Volume measurements of both arms will be performed for every participant after each treatment. Data collected at baseline and the last session will be used to calculate the primary outcome and secondary outcomes. Other data will be exploited for interim analyses and trial monitoring. The primary outcome is the absolute reduced limb volume ratio. Secondary outcomes are incidence of adverse events and change in quality of life. A t test or non-parameter test will be used to compare the difference between two groups, and assess the overall effectiveness of acupuncture using the SPSS software (version 12). Discussion This study will help expand our knowledge about the effectiveness of acupuncture on BCRL, and how acupuncture might be used in the management of this condition. Acupuncture may be a promising complement or alternative to conventional lymphedema treatment methods, if its effectiveness is confirmed. Trial registration ClinicalTrials.gov NCT02803736 (Registered on October 31, 2016).

No Association between <i>TNF-α</i> -308G/A Polymorphism and Idiopathic Recurrent Miscarriage: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

<div><p>Background</p><p>Conflicting results were reported on the association between the <i>TNF-α</i> -308G/A polymorphism and idiopathic recurrent miscarriage (IRM). Though three meta-analyses have been conducted on this topic, the conclusions were contradictory, and the results may be unreliable as certain crucial conditions were neglected.</p><p>Method</p><p>A complete search was conducted in PubMed, Cochrane Library, and Embase, other sources like Google Scholar, ClinicalTrial.gov and reference lists of relevant articles were also retrieved. All candidate articles were accessed and screened using specific inclusion and exclusion criteria. Statistical analyses were performed on data extracted from eligible studies using the STATA 12.0 software and the TSA 0.9 beta software.</p><p>Results</p><p>Eventually, 12 case-control studies from 11 publications (with 1,807 cases and 2,012 controls) were included in this meta-analysis, and no evidence of any significant association was found in the overall analyses between the <i>TNF-α</i> -308G/A polymorphism and IRM risk. However, significant association was shown in Asian population (four studies from three publications) in the dominant model (AA + GA vs. GG), the allelic model (A vs. G), and the heterozygote model (GA vs. GG).</p><p>Conclusions</p><p><i>TNF-α</i> -308G/A polymorphism is not associated with IRM risk. Though significant association was found in Asian population, the result needs further confirmation from more studies.</p></div

Primary characteristics of the 12 studies included in the meta-analysis.

<p>Primary characteristics of the 12 studies included in the meta-analysis.</p

Scale for quality assessment of studies included.

<p>Scale for quality assessment of studies included.</p

Primary results of overall meta-analyses and subgroup analyses.

<p>Primary results of overall meta-analyses and subgroup analyses.</p

Funnel plot of the 12 studies included in this meta-analysis.

<p>Funnel plot of the 12 studies included in this meta-analysis.</p

Trial sequential analysis of the studies included.

<p>A two-sided graph is plotted by TSA where the blue etched lines represent conventional significance boundaries, the blue line indicates the cumulative Z-score, and the red lines shows the α -spending boundary and the required information size.</p

Flow diagram of search and selection for studies.

<p>Flow diagram of search and selection for studies.</p

Primary differences between previous meta-analyses and the present meta-analysis on the association of <i>TNF-α</i> -308G/A Polymorphism and IRM.

<p>Primary differences between previous meta-analyses and the present meta-analysis on the association of <i>TNF-α</i> -308G/A Polymorphism and IRM.</p