A Study on Future Change in Surface Wind over the Korean Peninsula based on a Regional Climate Change Scenario

This study investigated the future change in surface wind over the Korean Peninsula using a high-resolution climate change scenario projected by a regional climate model (RCM). In the evaluation of historical runs (1981-2010), the RCM reasonably reproduced a 30-year annual mean surface wind and it also represented climatological seasonal wind pattern properly. To examine the future change in surface wind, the results from RCP8.5 run for 30 years (2071-2100) were compared with those from historical run. Despite of slight differences among seasons, southerly differences were overall dominant. This indicated that southerly prevailing wind for summer was intensified in the future climate, while northerly prevailing wind for other seasons was reduced. The changes in the seasonal mean surface wind were significantly associated with those in the surface pressure distribution surrounding the Korean Peninsula. In the future climate, the monthly mean wind speed was reduced compared in the present climate. However, the magnitude and annual variability of the annual maximum wind speed tended to increase in the future climate.clos

Climate Change Projections over CORDEX East Asia Domain using Multi-RCMs

In this study, global climate change scenario by HadGEM2-AO is dynamically downscaled using 5 Regional Climate Models (RCMs) for the Coordinated Regional Downscaling Experiment (CORDEX) - East Asia. All RCMs with 50-km horizontal resolution are integrated for continuous 71 years (1979-2049). In the evaluation of historical runs, all models tend to overestimate precipitation over the subtropical western North Pacific. For the surface air temperature, all models have cold biases over the East Asian continent compared to the observation. In the future projections, all models show similar changes in precipitation such as increasing precipitation over the tropical oceans and slightly decreasing precipitation over the East China Sea. In the mid-latitudes, convective precipitation tends to increase due to the enhanced convective instability, while non-convective precipitation tends to decrease slightly due to the changes in subtropical high and monsoon circulation. For surface air temperature, the warming tendency over the entire domain is captured by all models and it is larger in high latitude regions. The warming temperature is related to the increase in longwave radiation, which leads to prominent increase in minimum surface air temperature.clos

Photo-Cured Glycol Chitosan Hydrogel for Ovarian Cancer Drug Delivery

In this study, we prepared an injectable drug delivery depot system based on a visible light-cured glycol chitosan (GC) hydrogel containing paclitaxel (PTX)-complexed beta-cyclodextrin (β-CD) (GC/CD/PTX) for ovarian cancer (OC) therapy using a tumor-bearing mouse model. The hydrogel depot system had a 23.8 Pa of storage modulus at 100 rad/s after visible light irradiation for 10 s. In addition, GC was swollen as a function of time. However, GC had no degradation with the time change. Eventually, the swollen GC matrix affected the releases of PTX and CD/PTX. GC/PTX and GC/CD/PTX exhibited a controlled release of PTX for 7 days. In addition, GC/CD/PTX had a rapid PTX release for 7 days due to improved water solubility of PTX through CD/PTX complex. In vitro cell viability tests showed that GC/CD/PTX had a lower cell viability percentage than the free PTX solution and GC/PTX. Additionally, GC/CD/PTX resulted in a superior antitumor effect against OC. Consequently, we suggest that the GC/CD system might have clinical potential for OC therapy by improving the water solubility of PTX, as PTX is included into the cavity of β-CD

Injectable Glycol Chitosan Hydrogel Containing Folic Acid-Functionalized Cyclodextrin-Paclitaxel Complex for Breast Cancer Therapy

We prepared a drug carrier which consisted of injectable methacrylated glycol chitosan (MGC) hydrogel, and a conjugate of 6-monodeoxy-6-monoamino-β-cyclodextrin⋅hydrochloride (6-NH2-β-CD⋅HCl), polyethylene glycol (PEG), and folic acid (FA) for the local delivery and improved cellular uptake of paclitaxel (PTX) (MGC/CDPF-ic-PTX). CDPF refers to a conjugate of 6-NH2-β-CD⋅HCl, PEG, and FA. The anti-cancer effect was investigated using a xenograft mouse model. As controls, the animal study on MGC/PTX and MGC/CD-ic-PTX was performed. The swelling ratio of all samples was analyzed for 7 days, and it showed a gradual increase for 3 days and a maintained state afterward. From the release result, the MGC-based samples have an initial burst for 1 day and a sustained release for 7 days. Results of cytotoxicity and animal study showed the biocompatibility and superior anti-cancer effect of MGC/CDPF-ic-PTX against breast cancer. Furthermore, histological results showed the anti-cancer capacity of MGC/CDPF-ic-PTX against breast cancer. These findings suggest that MGC/CDPF-ic-PTX has clinical potential for breast cancer therapy

Platelet-derived mitochondria transfer facilitates wound-closure by modulating ROS levels in dermal fibroblasts

Platelets are known to improve the wound-repair capacity of mesenchymal stem cells (MSCs) by transferring mitochondria intercellularly. This study aimed to investigate whether direct transfer of mitochondria (pl-MT) isolated from platelets could enhance wound healing in vitro using a cell-based model. Wound repairs were assessed by 2D gap closure experiment in wound scratch assay using human dermal fibroblasts (hDFs). Results demonstrated that pl-MT were successfully internalized into hDFs. It increased cell proliferation and promoted the closure of wound gap. Importantly, pl-MT suppressed both intracellular and mitochondrial ROS production induced by hydrogen peroxide, cisplatin, and TGF-β in hDFs. Taken together, these results suggest that pl-MT transfer might be used as a potential therapeutic strategy for wound repair