41 research outputs found

    Solution Structure of Unstabilized Cyclic α-Aminoorganolithiums by 13

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    Application of Catalytic Dynamic Resolution of N

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    Spencer Roane Atkinson (1886–1970)

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    Unusual Conformational Effect in α-Aminoorganostannanes

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    Novel Modulator of NaV1.1 and NaV1.2 Na+ Channels in Rat Neuronal Cells

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    A novel modulator of sodium ion currents was synthesized in 6 steps from a protected dihydroxypyrrolidine nitrone, via 1,3-dipolar cycloaddition reaction with acrylamide. Sodium ion currents in B50 cells were evaluated in comparison to saxitoxin and tetrodotoxin and revealed an IC 50 of 15.7 μM. The new compound shows no evidence of binding to the C-lobe of the saxitoxin-binding protein saxiphilin
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