104 research outputs found
Algorithmic Complexity for Short Binary Strings Applied to Psychology: A Primer
Since human randomness production has been studied and widely used to assess
executive functions (especially inhibition), many measures have been suggested
to assess the degree to which a sequence is random-like. However, each of them
focuses on one feature of randomness, leading authors to have to use multiple
measures. Here we describe and advocate for the use of the accepted universal
measure for randomness based on algorithmic complexity, by means of a novel
previously presented technique using the the definition of algorithmic
probability. A re-analysis of the classical Radio Zenith data in the light of
the proposed measure and methodology is provided as a study case of an
application.Comment: To appear in Behavior Research Method
Benford's law predicted digit distribution of aggregated income taxes: the surprising conformity of Italian cities and regions
The yearly aggregated tax income data of all, more than 8000, Italian
municipalities are analyzed for a period of five years, from 2007 to 2011, to
search for conformity or not with Benford's law, a counter-intuitive phenomenon
observed in large tabulated data where the occurrence of numbers having smaller
initial digits is more favored than those with larger digits. This is done in
anticipation that large deviations from Benford's law will be found in view of
tax evasion supposedly being widespread across Italy. Contrary to expectations,
we show that the overall tax income data for all these years is in excellent
agreement with Benford's law. Furthermore, we also analyze the data of
Calabria, Campania and Sicily, the three Italian regions known for strong
presence of mafia, to see if there are any marked deviations from Benford's
law. Again, we find that all yearly data sets for Calabria and Sicily agree
with Benford's law whereas only the 2007 and 2008 yearly data show departures
from the law for Campania. These results are again surprising in view of
underground and illegal nature of economic activities of mafia which
significantly contribute to tax evasion. Some hypothesis for the found
conformity is presented.Comment: 18 pages, 5 tables, 4 figures, 61 references, To appear in European
Physical Journal
In vitro and in vivo characterization of highly purified Human Mesothelioma derived cells
<p>Abstract</p> <p>Background</p> <p>Malignant pleural mesothelioma is a rare disease known to be resistant to conventional therapies. A better understanding of mesothelioma biology may provide the rationale for new therapeutic strategies. In this regard, tumor cell lines development has been an important tool to study the biological properties of many tumors. However all the cell lines established so far were grown in medium containing at least 10% serum, and it has been shown that primary cell lines cultured under these conditions lose their ability to differentiate, acquire gene expression profiles that differ from that of tissue specific stem cells or the primary tumor they derive from, and in some cases are neither clonogenic nor tumorigenic. Our work was aimed to establish from fresh human pleural mesothelioma samples cell cultures maintaining tumorigenic properties.</p> <p>Methods</p> <p>The primary cell cultures, obtained from four human pleural mesotheliomas, were expanded in vitro in a low serum proliferation-permissive medium and the expression of different markers as well as the tumorigenicity in immunodeficient mice was evaluated.</p> <p>Results</p> <p>The established mesothelioma cell cultures are able to engraft, after pseudo orthotopic intraperitoneal transplantation, in immunodeficient mouse and maintain this ability to after serial transplantation. Our cell cultures were strongly positive for CD46, CD47, CD56 and CD63 and were also strongly positive for some markers never described before in mesothelioma cell lines, including CD55, CD90 and CD99. By real time PCR we found that our cell lines expressed high mRNA levels of typical mesothelioma markers as mesothelin (MSLN) and calretinin (CALB2), and of BMI-1, a stemness marker, and DKK1, a potent Wingless [WNT] inhibitor.</p> <p>Conclusions</p> <p>These cell cultures may provide a valuable in vitro and in vivo model to investigate mesothelioma biology. The identification of new mesothelioma markers may be useful for diagnosis and/or prognosis of this neoplasia as well as for isolation of mesothelioma tumor initiating cells.</p
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