Assessment of Effectiveness of Ozonated Olive Oil Fused with Corticosteroids for the Management of Oral Erosive Lichen Planus: A Novel Approach

Erosive lichen planus is counted amongst the most debilitating conditions of oral cavity which has multifactorial etiology and Malignant turnover potential. It has been documented that ozonated olive oil have healing, anti-inflammatory, antimicrobial and antioxidant properties and thus have great potential in management of the ulcerative lesions. Present study is aimed to evaluate and compare the efficacy of using ozonated olive oil combined with systemic steroid and antioxidant in the management of erosive lichen planus. Materials and methods: Eighty patients with a confirmed clinical and histopathologic diagnosis of erosive OLP were randomly allocated into four groups. Group I, II, III and IV were prescribed systemic Prednisolone 40 mg/day,soft-gel capsule lycopene (6 mg/day), combination therapy of systemic steroid (40mg/day) along with ozonated olive oil and combination therapy of lycopene (16 mg/day) and ozonated olive oil respectively. OLP clinical course was assessed by measuring severity of pain, burning sensation(VAS), clinical signs(scale of Thongprasom) and efficacy of the treatment(efficacy index methods of Liu set). Patients were monitored on regular follow up