Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio

The Environmental Impact of Cambodia's Ancient City of Mahendraparvata (Phnom Kulen)

The Khmer kingdom, whose capital was at Angkor from the 9(th) to the 14(th)-15(th) century, was founded in 802 by king Jayavarman II in a city called Mahandraparvata, on Phnom Kulen. Virtually nothing more is known of Mahandraparvata from the epigraphic sources, but systematic archaeological survey and excavation have identified an array of cultural features that point to a more extensive and enduring settlement than the historical record indicates. Recent remote sensing data have revolutionized our view, revealing the remains of a city with a complex and spatially extensive network of urban infrastructure. Here, we present a record of vegetation change and soil erosion from within that urban network, dating from the 8(th) century CE. Our findings indicate approximately 400 years of intensive land use, punctuated by discrete periods of intense erosion beginning in the mid 9(th) century and ending in the late 11(th) century. A marked change in water management practices is apparent from the 12(th) century CE, with implications for water supply to Angkor itself. This is the first indication that settlement on Mahendraparvata was not only extensive, but also intensive and enduring, with a marked environmental impact