Electronic equalization for advanced modulation formats in dispersion-limited systems

We investigate in this letter the use of electronic equalization on dispersion limited systems for different modulation formats. Besides analyzing equalization on standard NRZ intensity modulation as a reference, we focus on two advanced modulation formats, Duobinary and Differential Phase Shift Keying (DPSK) which are recently gaining large attention. We demonstrate that the introduction of an electronic equalizer strongly improves standard NRZ performance, whereas it has a limited effect on Duobinary and DPSK formats. Moreover, we give rules for the optimal choice of the equalizer transversal filter parameters, i.e., the number of taps and the delay between taps

Synchronization of a WDM Packet-Switched Slotted Ring

In this paper, we present two different strategies of slot synchronization in wavelength-division-multiplexing (WDM) packet-switched slotted-ring networks. Emphasis is given to the architecture behind the WDM Optical Network Demonstrator over Rings (WONDER) project, which is based on tunable transmitters and fixed receivers. The WONDER experimental prototype is currently being developed at the laboratories of Politecnico di Torino. In the former strategy, a slotsynchronization signal is transmitted by the master station on a dedicated control wavelength; in the latter, slave nodes achieve slot synchronization aligning on data packets that are received from the master. The performance of both synchronization strategies, particularly in terms of packet-collision probability, was evaluated by simulation. The technique based on transmitting a timing signal on a dedicated control wavelength achieves better performance, although it is more expensive due to the need for an additional wavelength. However, the technique based on aligning data packets that are received from the master, despite attaining lower timing stability, still deserves further study, particularly if limiting the number of wavelengths and receivers is a major requirement. Some experimental results, which were measured on the WONDER prototype, are also shown. Measurement results, together with theoretical findings, demonstrate the good synchronization performance of the prototype

High-Speed Communications Over Polymer Optical Fibers for In-Building Cabling and Home Networking

This paper focuses on high-speed cabling using polymer optical fibers (POF) in home networking. In particular, we report about the results obtained in the POF-ALL European Project, which is relevant to the Sixth Framework Program, and after two years of the European Project POF-PLUS, which is relevant to the Seventh Framework Program, focusing on their research activities about the use of poly-metyl-metha-acrilate step-index optical fibers for home applications. In particular, for that which concerns POF-ALL, we will describe eight-level pulse amplitude modulation (8-PAM) and orthogonal frequency-division multiplexing (OFDM) approaches for 100-Mb/s transmission over a target distance of 300 m, while for that which concerns POF-PLUS, we will describe a fully digital and a mixed analog-digital solution, both based on intensity modulation direct detection, for transmitting 1 Gb/s over a target distance of 50 m. The ultimate experimental results from the POF-ALL project will be given, while for POF-PLUS, which is still ongoing, we will only show our most recent preliminary results

Targeting metabolic reprogramming in metastatic melanoma: The key role of nicotinamide phosphoribosyltransferase (NAMPT)

Cancer cells rewire their metabolism to support proliferation, growth and survival. In metastatic melanoma the BRAF oncogenic pathway is a master regulator of this process, highlighting the importance of metabolic reprogramming in the pathogenesis of this tumor and offering potential therapeutic approaches. Metabolic adaptation of melanoma cells generally requires increased amounts of NAD+, an essential redox cofactor in cellular metabolism and a signaling molecule. Nicotinamide phosphoribosyltransferase (NAMPT) is the most important NAD+ biosynthetic enzyme in mammalian cells and a direct target of the BRAF oncogenic signaling pathway. These findings suggest that NAMPT is an attractive new therapeutic target, particularly in combination strategies with BRAF or MEK inhibitors. Here we review current knowledge on how oncogenic signaling reprograms metabolism in BRAF-mutated melanoma, and discuss how NAMPT/NAD+ axis contributes to these processes. Lastly, we present evidence supporting a role of NAMPT as a novel therapeutic target in metastatic melanoma