8 research outputs found

    Stone induced ureteral rupture: The worst-case scenario. A case report

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    Forniceal rupture secondary to acute ureteral obstruction is relatively common. However, spontaneous ureteral rupture is less frequently encountered. Most reported cases were stone related, localized at the ureteropelvic junction and managed in a minimally invasive manner. We present a case of stone induced ureteral rupture below the UPJ, with bacterial and fungal superinfections, that failed conservative management and lead eventually to nephrectomy. No such scenario has ever been reported in the literature. As rupture of the ureter can cause serious complications, including urinoma, sepsis and sometimes kidney loss, prompt recognition, treatment and follow-up of the condition is therefore necessary

    Intra-Modal Phase-Sensitive Four-Wave Mixing in a Few-Mode Fiber

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    International audienceWe experimentally demonstrate intra-modal signal/idler-degenerate phase-sensitive four-wave mixing in two LP modes (LP01 and LP11) of a 2-km long step-index 4-mode fiber

    « Cahiers d’habitats » Natura 2000. Actualisation des interprĂ©tations des habitats d’intĂ©rĂȘt communautaire. Fascicule 1 - Habitats cĂŽtiers et halophytiques. Fiches gĂ©nĂ©riques version 2 (UE 1130 Ă  UE 1510*)

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    International audienceCe fascicule 1 est consacrĂ© aux habitats cĂŽtiers et halophytiques prĂ©sents en France :- 2 habitats de transition entre milieu marin et milieu terrestre (UE 1130 et 1150*) ;- 4 habitats des Falaises maritimes et plages de galets (UE 1210 Ă  1240) ;- 4 habitats des Marais et prĂ©s salĂ©s atlantiques et continentaux (UE 1310 Ă  1340*) ;- 2 habitats des Marais et prĂ©s salĂ©s mĂ©diterranĂ©ens et thermo-atlantiques (UE 1410 Ă  1420) ;- 1 habitat des Steppes intĂ©rieures halophiles et gypsophiles (UE 1510*).Suivant les principes mĂ©thodologiques prĂ©sentĂ©s dans la notice gĂ©nĂ©rale des Cahiers d’habitats v2, 6 d’entre eux ont Ă©tĂ© catĂ©gorisĂ©s en habitats Ă  logiquebiotope (dont 3 sous condition de prĂ©sence de leurs vĂ©gĂ©tations indicatrices) et 7 en habitats Ă  logique vĂ©gĂ©tation (dont 5 sous condition de biotope)

    « Cahiers d’habitats » Natura 2000. Actualisation des interprĂ©tations des habitats d’intĂ©rĂȘt communautaire. Notice gĂ©nĂ©rale pour les fiches gĂ©nĂ©riques v2

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    Cette notice gĂ©nĂ©rale prĂ©sente la dĂ©marche et les principes mĂ©thodologiques suivis par le groupe de travail pour l’actualisation des interprĂ©tations des habitats d’intĂ©rĂȘt communautaire et des fiches gĂ©nĂ©riques des Cahiers d’habitats.Parmi ces principes mĂ©thodologiques, on notera tout particuliĂšrement la catĂ©gorisation des habitats en habitats Ă  logique biotope ou Ă  logique vĂ©gĂ©tation et la superposition des habitats

    « Cahiers d’habitats » Natura 2000. Actualisation des interprĂ©tations des habitats d’intĂ©rĂȘt communautaire. Fascicule 3 - Habitats des eaux douces. Fiches gĂ©nĂ©riques version 2 (UE 3110 Ă  UE 3290)

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    Ce troisiĂšme fascicule est consacrĂ© aux 15 habitats des eaux douces prĂ©sents en France :- 7 habitats des eaux dormantes (UE 3110 Ă  3170*) ;- 8 habitats des eaux courantes (UE 3220 Ă  3290).Suivant les principes mĂ©thodologiques prĂ©sentĂ©s dans la notice gĂ©nĂ©rale des Cahiers d’habitats v2, 7 d’entre eux ont Ă©tĂ© catĂ©gorisĂ©s en habitats Ă  logique biotope sous condition de prĂ©sence de leurs vĂ©gĂ©tations indicatrices et 8 en habitats Ă  logique vĂ©gĂ©tation.Divers cas de superpositions entre habitats d’intĂ©rĂȘt communautaire ont Ă©galement Ă©tĂ© recensĂ©s

    Immunodynamics of explanted human tumors for immuno-oncology

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    International audienceDecision making in immuno-oncology is pivotal to adapt therapy to the tumor microenvironment (TME) of the patient among the numerous options of monoclonal antibodies or small molecules. Predicting the best combinatorial regimen remains an unmet medical need. Here, we report a multiplex functional and dynamic immuno-assay based on the capacity of the TME to respond to ex vivo stimulation with twelve immunomodulators including immune checkpoint inhibitors (ICI) in 43 human primary tumors. This "in sitro" (in situ/in vitro) assay has the potential to predict unresponsiveness to anti-PD-1 mAbs, and to detect the most appropriate and personalized combinatorial regimen. Prospective clinical trials are awaited to validate this in sitro assay
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