Russian regions in the system of international cooperation

© 2017, by ASERS® Publishing. All rights reserved. This article is devoted to the research of international cooperation ties in Russian regions. Dynamics of foreign trade turnover in regions is investigated. The dynamics of foreign trade turnover of the Republic of Tatarstan is particularly researched. The authors proposed the method of analysis of international relations of the region on the basis of allocation of the core zone of international cooperation, whereas a core zone is a group of countries with which the researched region has had stable relations for a certain period of time. Special attention in the article is paid to the international relations and cooperation of the Republic of Tatarstan. The choice of this region of the Russian Federation is caused by the significant role of the Republic of Tatarstan in international relations of Russia and its economy. Confirmation of a hypothesis that participants of the international economic relations at the regional level form around themselves the zone of the international cooperation differing in heterogeneity is the result of scientific research. The offered technique can be used to carry out monitoring of international relations of the Russian regions

Functions and main directions of development of the integrated educational-industrial complex “college—university—enterprise”

© 2015, Review of European Studies. All right reserved. Structural and functional stability of college, university and industry integration in regional system of professional education is achieved through the creation of common educational-industrial space. The leading approach to the study of this problem is an integrative approach which allows predicting the transition of the integrated system “college—university—enterprise” on the qualitatively new level due to the agreed goals, tasks, functions, and actions of this system subjects, contributing to the implementation of forward-looking professional training of competitive specialists. The main functions of the development of the integrated educational-industrial complex “college—university—enterprise” in the article are indicated as follows: coordinating, prognostic, anticipatory, consolidating, corporate, sublimating. The article submissions represent a theoretical value to researchers concerned with integration issues, and also have practical significance for subjects of the integrated system of “education—production” in order to prepare specialists meeting the requirements of modern production

Extragenital diseases in pregnant women of different age groups in Dagestan

In recent time the tendency to increase of a frequency of extragenital deseases among pregnant women ,that is associated with the deterioration of the general health, is observed. A comparative analysis of hospital morbidity in pregnant woman living in Dagestan in 15-49 years old with extragenital diseases was conducted. A proportion of women with extragenital pathology among hospitalized women is 25.4%. A share of blood diseases in the structure of extragenital diseases is 52%, diseases of the digestive system – 14.5%, especially among women of active reproductive age (20-29 years old). Therefore, the extragenital patology can cause a development of various obstetric complications and contributes to the deterioration of women's reproductive health and a violation of the reproduction’s processes.В последнее время наблюдается тенденция к увеличению частоты экстрагенитальных заболеваний у беременных, что связывают с ухудшением общего здоровья женщин. Наличие патологического течения беременности в 60-70% обусловлено скрытой или хронической экстрагенитальной патологией. Проведен сравнительный анализ госпитальной заболеваемости 2173 беременных женщин в возрасте 15-49 лет, проживающих в республике дагестан, на предмет наличия экстрагенитальных болезней. доля женщин с экстрагенитальной патологией среди госпитализируемых составляет 25,4%. Наибольший удельный вес в структуре экстрагенитальных заболеваний имеют болезни крови (52%) и заболевания органов пищеварения (14,5%), особенно у женщин активного репродуктивного возраста (20-29 лет). таким образом, экстрагенитальная патология может обусловить развитие различных акушерских осложнений и способствовать ухудшению репродуктивного здоровья женщин, вызывая нарушение процессов воспроизводства

The effect of the age of a pregnant woman on the health of a newborn

The purpose: an estimation of age features of the pregnant woman and health of their children in families of the Dagestan population. Material and methods. The work analyzes data on 491 newborns born in Makhachkala in 2016, women aged 15 to 49 years. The results of the study showed that the high marks of newborn boys on Apgar scale are observed in women aged 20-24 and 35-39 years, the lowest - at the age of 15-20 years. The Apgar scores increase with the age of women from 20 to 44 years. Girls are born with a higher level of adaptation to the environment than boys. In the Dagestan population, women are mainly fed breast milk for boys longer than 1 year after 3-4 births. The conclusion. The duration of feeding of girls by breast milk to women aged 15-19 years is on average 4,5 months, and at the age of 40-44 years -11,3 months. On average, the weight of boys at birth tends to increase with age of the woman and the number of births.Цель: оценка возрастных особенностей беременной женщины и здоровья их детей в семьях дагестанской популяции. Материал и методы. В работе проведен анализ данных о 491 новорожденном, рожденном в г. Махачкале в 2016 году, женщинами в возрасте от 15 до 49 лет. Результаты исследования показали, что высокие баллы новорожденных мальчиков по шкале Апгар наблюдаются у женщин в возрасте 20-24 и 35-39 лет, самые низкие - в возрасте 15-20 лет. Сумма баллов по шкале Апгар увеличивается по мере возрастания возраста женщин от 20 до 44 лет. Девочки рождаются с более высоким уровнем адаптации к окружающей среде, нежели мальчики. В дагестанской популяции женщины в основном кормят грудным молоком мальчиков дольше 1 года после 3-4-х родов. Заключение. Продолжительность кормления девочек грудным молоком женщинами в возрасте 15-19 лет в среднем составляет 4,5 месяца, а в возрасте 40-44 лет -11,3 месяца. В среднем вес мальчиков при рождении имеет тенденцию к росту по мере увеличения возраста женщины и числа родов

The supplementary education teacher’s portfolio: Essence, functions, structure and design principles

© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. The article discloses the contradictions, which define the necessity and possibility to use teacher’s portfolio in the system of children’s supplementary education. It gives the author’s interpretation of the concept «supplementary education teacher’s portfolio», defines objectives, the portfolio functions and the principles of its design. The article offers the author’s structure of the supplementary education teacher’s portfolio, which reflects the main directions of the teacher’s professional activities, allows demonstrating the achievements and the results of these activities. The authors describe the alternatives to use the portfolio in supplementary education. The article reveals the risks of portfolio implementation in the institutions of supplementary education. Practical recommendations for the teacher’s portfolio development given in the article are practice– oriented. The article addresses the administration and the teachers of the children’s supplementary education institutions, the lecturers of the teacher’s training colleges, who train future teachers of the supplementary education as well as the educators of the extended education within the process of the professional skills improvement for supplementary education teachers

LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The negative impact of tobacco smoke on the human body is due to a wide range of harmful substances including volatile organic compounds (VOCs). Some VOCs of tobacco smoke metabolize in human organism into mercapturic acids (MAs). The determination of the amount of MAs in readily available biological fluids, for example in urine, allows to assess the level of exposure of these VOCs in a particular person. It is useful to assess the impact of individual VOCs on the body together with the assessment of the intake of nicotine. The intake of nicotine can be determined by the content of its metabolites in the urine, in particular by the content of trans-3′-hydroxycotinine (tH-Cot). A joint assessment of the concentrations of trans-3′-hydroxycotinine and MAs in urine allows obtaining selective information about effects of different VOCs and nicotine on the smoker’s body. We have developed a liquid chromatography–mass spectrometry (LC-MS) method for simultaneous quantifying of tH-Cot and three MAs: N-Acetyl-S-(3-hydroxypropyl)cysteine (HPMA), N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine (HMPMA), N-Acetyl-S-(2-cyanoethyl)-L-cysteine (CEMA). We used this method to quantify the levels of MAs and tH-Cot in the urine of a group of 15 smokers just before and 5 days after smoking cessation. For all studied compounds, we have found statistically significant changes in concentration on the fifth day of smoking cessation. The method developed can be used to jointly assess the levels of exposure to nicotine and VOCs in the study of various tobacco products

Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors

Coronary artery disease remains one of the primary healthcare problems due to the high cost of treatment, increased number of patients, poor clinical outcomes, and lack of effective therapy. Though pharmacological and surgical treatments positively affect symptoms and arrest the disease progression, they generally exhibit a limited effect on the disease outcome. The development of alternative therapeutic approaches towards ischemic disease treatment, especially of decompensated forms, is therefore relevant. Therapeutic angiogenesis, stimulated by various cytokines, chemokines, and growth factors, provides the possibility of restoring functional blood flow in ischemic tissues, thereby ensuring the regeneration of the damaged area. In the current study, based on the clinically approved plasmid vector pVax1, multigenic constructs were developed encoding vascular endothelial growth factor (VEGF), fibroblast growth factors (FGF2), and the DsRed fluorescent protein, integrated via picornaviruses’ furin-2A peptide sequences. In vitro experiments demonstrated that genetically modified cells with engineered plasmid constructs expressed the target proteins. Overexpression of VEGF and FGF2 resulted in increased levels of the recombinant proteins. Concomitantly, these did not lead to a significant shift in the general secretory profile of modified HEK293T cells. Simultaneously, the secretome of genetically modified cells showed significant stimulating effects on the formation of capillary-like structures by HUVEC (endothelial cells) in vitro. Our results revealed that when the multicistronic multigene vectors encoding 2A peptide sequences are created, transient transgene co-expression is ensured. The results obtained indicated the mutual synergistic effects of the growth factors VEGF and FGF2 on the proliferation of endothelial cells in vitro. Thus, recombinant multicistronic multigenic constructs might serve as a promising approach for establishing safe and effective systems to treat ischemic diseases

Predictors of atrial fibrillation in patients with dualchamber pacemakers

During prospective study the predictors of primary AF incidence were studied in 87 patients (mean age 64,3±10.5 years) with chronic ischemic heart disease after dual chamber pacemakers (DCP) implantation: 39 - with sick sinus syndrome (SSS), 43 - with the atrioventricular block II-III degree (AVB), 5 - with binodal disease. The end point was the primary incidence of sustained paroxysmal AF (>30 seconds). The primary AF development is noted at 16 (18,4%) patients later 10 months after DCP implantation. At comparison of groups with and without AF by means of Stjudents criterion and Fisher's nonparametric criterion the factors associating with AF have been revealed: presence AVB (p=0,004), a male (p=0,01), left atrium dilation (p=0,04), right ventricular stimulation percent >60% (p=0,009), atrial stimulation percent 30 сек. Первичное развитие ФП отмечено у 16 (18,4%) пациентов спустя 10 месяцев после имплантации ЭКС. При сравнении групп с ФП и без ФП с помощью критерия Стъюдента и непараметрического критерия Фишера были выявлены факторы, ассоциирующиеся с ФП: наличие АВБ (р=0,004), мужской пол (р=0,01), дилатация левого предсердия (р=0,04), доля правожелудочковой стимуляции >60% (р=0,009), доля предсердной стимуляции <35% (р=0,04), длительность детектируемой АВ-задержки <180мсек (р=0,03). Методом бинарной логистической регрессии выявлено 2 независимых предиктора ФП: длительность детектируемой АВ-задержки <180 мс и принадлежность к мужскому полу. Наличие в ЭКС алгоритма, способствующего спонтанному АВ проведению, достоверно снижало развитие ФП только при СССУ (р=0,02)

Валидация Бостонского опросника по оценке карпального туннельного синдрома (Boston Carpal Tunnel Questionnaire) в России

International scales and questionnaires have become widespread in Russian neurology. Validation is a procedure of top priority necessary before applying this kind of diagnostic instrument in Russian-speaking population. In this article, validation of the Boston Carpal Tunnel Questionnaire (BCTQ) intended for patients with this disease is described. Use of validated Russian version would allow to objectively evaluate severity of clinical manifestations of carpal tunnel syndrome and follow patient dynamics. We present the official BCTQ version recommended for use in Russia, as well as data that showed high sensitivity and reliability of this instrument for clinical evaluation of carpal tunnel syndrome.В отечественной неврологии широкое распространение получили международные шкалы и опросники. Валидация – приоритетная процедура, необходимая перед применением такого рода диагностических инструментов в русскоязычной популяции. В настоящей статье описана работа по валидации Бостонского опросника по оценке карпального туннельного синдрома (Boston Carpal Tunnel Questionnaire, BCTQ), предназначенного для использования у пациентов с вышеуказанным заболеванием. Применение валидированной русскоязычной версии позволит объективно оценить выраженность клинических проявлений карпального туннельного синдрома (синдрома запястного канала) и отследить динамику состояния пациента. Представлены не только официальная версия BCTQ, рекомендованная для применения в России, но и данные, показавшие высокую чувствительность и надежность этого инструмента клинической оценки карпального туннельного синдрома