Product ban versus risk management by setting emission and technology requirements: The effect of different regulatory schemes taking the use of trichloroethylene in Sweden and Germany as an example

This report highlights the opportunities inherent in smart regulatory measures to effectively reduce risks related to hazardous substance emissions and exposure, and underscores the danger of simplistic and ineffective policy. The example of different regulatory approaches used in Germany and Sweden to regulate the use of trichloroethylene was taken as the basis for the study. During the 1990s, due to environmental, health and safety considerations, the use of trichloroethylene in Europe was a subject of broad concern. As a consequence, the use of trichloroethylene became regulated through multiple approaches, such as labelling, handling regulations and performance standards. Since that time the absolute emissions of trichloroethylene in Europe have been decreasing consistently in all member states. These results were achieved by various regulatory measures governing the use of trichloroethylene in industrial applications that have been introduced by individual Member States. However, given the implementation responsibility at Member State level not all member States have implemented the same set of regulatory measures. In Germany, for example, the use of trichloroethylene is regulated through strict technical standards for equipment and emissions that has required companies to replace existing old machines with the state-of-the-art equipment. In Sweden a general ban on trichloroethylene use was introduced in 1996, which however eventually evolved into an exemption permit system for companies that found no alternative to degreasing with trichloroethylene. --

Forschen für die Ewigkeit: Bewertung und Archivierung von Forschungsdaten als neues Arbeitsgebiet für Hochschularchive

Bewertung und Archivierung von Forschungsdaten als neues Arbeitsgebiet für Hochschularchiv

Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells

Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. NSCs can be directly isolated from fetal or adult nervous tissue, or derived from embryonic stem cells. Here, we describe the efficient conversion of human adult bone marrow stromal cells (hMSC) into a neural stem cell-like population (hmNSC, for human marrow-derived NSC-like cells). These cells grow in neurosphere-like structures, express high levels of early neuroectodermal markers, such as the proneural genes NeuroD1, Neurog2, MSl1 as well as otx1 and nestin, but lose the characteristics of mesodermal stromal cells. In the presence of selected growth factors, hmNSCs can be differentiated into the three main neural phenotypes: astroglia, oligodendroglia and neurons. Clonal analysis demonstrates that individual hmNSCs are multipotent and retain the capacity to generate both glia and neurons. Our cell culture system provides a powerful tool for investigating the molecular mechanisms of neural differentiation in adult human NSCs. hmNSCs may therefore ultimately help to treat acute and chronic neurodegenerative diseases

Product ban versus risk management by setting emission and technology requirements: The effect of different regulatory schemes taking the use of trichloroethylene in Sweden and Germany as an example

This report highlights the opportunities inherent in smart regulatory measures to effectively reduce risks related to hazardous substance emissions and exposure, and underscores the danger of simplistic and ineffective policy. The example of different regulatory approaches used in Germany and Sweden to regulate the use of trichloroethylene was taken as the basis for the study. During the 1990s, due to environmental, health and safety considerations, the use of trichloroethylene in Europe was a subject of broad concern. As a consequence, the use of trichloroethylene became regulated through multiple approaches, such as labelling, handling regulations and performance standards. Since that time the absolute emissions of trichloroethylene in Europe have been decreasing consistently in all member states. These results were achieved by various regulatory measures governing the use of trichloroethylene in industrial applications that have been introduced by individual Member States. However, given the implementation responsibility at Member State level not all member States have implemented the same set of regulatory measures. In Germany, for example, the use of trichloroethylene is regulated through strict technical standards for equipment and emissions that has required companies to replace existing old machines with the state-of-the-art equipment. In Sweden a general ban on trichloroethylene use was introduced in 1996, which however eventually evolved into an exemption permit system for companies that found no alternative to degreasing with trichloroethylene

EpCAM expression in primary tumour tissues and metastases: an immunohistochemical analysis

Epithelial cell adhesion molecule (EpCAM) is a cell surface protein with oncogenic features that is expressed on healthy human epithelia and corresponding malignant tumours. EpCAM expression frequently correlates with more aggressive tumour behaviour and new EpCAM-specific therapeutic agents have recently been approved for clinical use in patients with cancer. However, no consensus exists on how and when to evaluate EpCAM expression in patients with cancer