Where would we be without counterfactuals?

Huw Price gives his inaugural lecture as Bertrand Russell Professor of Philosophy. Bertrand Russell’s celebrated essay “On the Notion of Cause” was first delivered to the Aristotelian Society on 4 November 1912, as Russell’s Presidential Address. The piece is best known for a passage in which its author deftly positions himself between the traditional metaphysics of causation and the British crown, firing broadsides in both directions: “The law of causality”, Russell declares, “Like much that passes muster in philosophy, is a relic of a bygone age, surviving, like the monarchy, only because it is erroneously supposed to do no harm.” To mark the lecture’s centenary, we offer a contemporary view of the issues Russell here puts on the table, and of the health or otherwise, at the end of the essay’s first century, of his notorious conclusion

From Mendel’s discovery on pea to today’s plant genetics and breeding

In 2015, we celebrated the 150th anniversary of the presentation of the seminal work of Gregor Johann Mendel. While Darwin’s theory of evolution was based on differential survival and differential reproductive success, Mendel’s theory of heredity relies on equality and stability throughout all stages of the life cycle. Darwin’s concepts were continuous variation and “soft” heredity; Mendel espoused discontinuous variation and “hard” heredity. Thus, the combination of Mendelian genetics with Darwin’s theory of natural selection was the process that resulted in the modern synthesis of evolutionary biology. Although biology, genetics, and genomics have been revolutionized in recent years, modern genetics will forever rely on simple principles founded on pea breeding using seven single gene characters. Purposeful use of mutants to study gene function is one of the essential tools of modern genetics. Today, over 100 plant species genomes have been sequenced. Mapping populations and their use in segregation of molecular markers and marker–trait association to map and isolate genes, were developed on the basis of Mendel's work. Genome-wide or genomic selection is a recent approach for the development of improved breeding lines. The analysis of complex traits has been enhanced by high-throughput phenotyping and developments in statistical and modeling methods for the analysis of phenotypic data. Introgression of novel alleles from landraces and wild relatives widens genetic diversity and improves traits; transgenic methodologies allow for the introduction of novel genes from diverse sources, and gene editing approaches offer possibilities to manipulate gene in a precise manner

Epigenesis/Preformation(ism)

At the end of the nineteenth century, epigenesis and preformationism were presented in An Illustrated Dictionary of Medicine, Biology and allied Sciences as: “epigenesis is in biology, the theory that holds the embryo to be the result of the union of the male and female elements, and the fully formed organism the result of a gradual process of differentiation, in distinction to the theory of encasement, preformation, or evolution, which held the embryo to pre-exist in a minute form within the germ”

In what sense does 'nothing make sense except in the light of evolution'?

Dobzhansky argued that biology only makes sense if life on earth has a shared history. But his dictum is often reinterpreted to mean that biology only makes sense in the light of adaptation. Some philosophers of science have argued in this spirit that all work in ‘proximal’ biosciences such as anatomy, physiology and molecular biology must be framed, at least implicitly, by the selection histories of the organisms under study. Others have denied this and have proposed non-evolutionary ways in which biologists can frame these investigations. This paper argues that an evolutionary perspective is indeed necessary, but that it must be a forward-looking perspective informed by a general understanding of the evolutionary process, not a backward-looking perspective informed by the specific evolutionary history of the species being studied. Interestingly, it turns out that there are aspects of proximal biology that even a creationist cannot study except in the light of a theory of their effect on future evolutio