56 research outputs found
Evaluation écotoxicologique d’un polluant pharmaceutique émergent : le Pyridinium du Furosémide (PoF)
No full textInternational audienc
Ecotoxicological Study of an Emerging Pharmaceutical Pollutant: The Pyridinium of Furosemide (PoF)
No full textInternational audienc
Évaluation des effets de perturbation endocrinienneinduits par un polluant pharmaceutique émergent et ses produits de dégradation chez Daphniamagna.
No full textInternational audienc
Identification of Amino Acid Residues in Bone Morphogenetic Protein-1 Important for Procollagen C-proteinase Activity
No full textPost-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein
No full textBone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity
No full textA complete domain structure of Drosophila tolloid is required for cleavage of short gastrulation
No full textIdentification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: Chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1)
No full textStructural and functional evidence for a substrate exclusion mechanism in mammalian tolloid like-1 (TLL-1) proteinase
Get PDFBone morphogenetic protein-1 (BMP-1)/tolloid proteinases are fundamental to regulating dorsal ventral patterning and extracellular matrix deposition. In mammals there are four proteinases, the splice variants BMP-1 and mammalian tolloid (mTLD), and tolloid like-1 and -2 (TLL-1/2). BMP-1 has the highest catalytic activity and lacks three non-catalytic domains. We demonstrate that TLL-1, which has intermediate activity, forms a calcium-ion dependent dimer with monomers stacked side-by-side. In contrast, truncated TLL-1 molecules having the same shorter structure as BMP-1 are monomers and have improved activity towards their substrate chordin. The increased activity exceeds not only that of full-length TLL-1 but also BMP-1. STRUCTURED SUMMARY: MINT-7386098: BMP-1 (uniprotkb:P13497) cleaves (MI:0194) Chordin (uniprotkb:Q9H2X0) by protease assay (MI:0435
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