MIA

Throughout this manuscript, I will share everything that went into the filmmaking process of my thesis film MIA. I will explore what went into making the film, both pre-and post production, and an overall description of each detail from the set. I will also discuss my education at the University of New Orleans and the person I am today from when I started three years ago

Three-dimensional assessment of dentofacial deformity in children with clefts

Background: Changes in clinical management; advances in non-invasive three-dimensional imaging; developments in methods of shape analysis. Aim: To assess three-dimensional dentofacial deformity with a view to early appraisal of primary surgical outcome. Results: Significant differences in upper lip morphology were found between the cleft children and their unaffected peers; nasal asymmetry that became more obvious in function was noted in cleft children; the maxillary dental arches of the children with repaired cleft palate were shallow, short and narrow; and the dental arch, deformity and the facial soft tissue deformity were unrelated. Contributions to the field: It has been shown that deviation from normal could be detected as young as 3 years of age using computerised stereophotogrammetry; preliminary, objective, three-dimensional analysis of facial function has been completed in young children; the accuracy of three-dimensional CT scanning of dentate study models and the time cost of data collection were quantified; and this study has produced a body of three-dimensional data that can test and support analytical advances

Single-Use pH sensor via a coplanar pH glass electrode design

The elimination of high temperature and high pressure sterilization processes by the advent of Single-Use-Systems (SUS) opens up a new era for the glass electrode based pH sensor. Without the requirement for pretreatment of a pH glass electrode under high temperature and pressure, the classic pH sensing technology delivers a more reliable, more rugged, and more accurate pH measurement. However, the innovative and unique SUS practice also posts new challenges, such as the long shelf-life requirement and the limitation of access to the sensor for calibration once on site,. At Broadley-James Corporation, a new manufacturing technology has been developed to allow a coplanar pH glass electrode design. This innovative sensor design will allow the sensing surface to transfer from a storage/calibration position to a measurement position while maintaining a fully closed and sterile system status. A single use pH sensor based on this design exhibits features such as shelf life up to 2 years post gamma, on site calibration capability, post use validation capability, and 2 – 12 pH range coverage. This poster will present a coplanar tubular glass electrode design for upstream (bag) installation, as well as a coplanar flat glass electrode design for downstream (flow path) installation. Sensor accuracy verification, design details, and preliminary test results will also be presented

Nitrofurantoin-induced radiation recall dermatitis.

Radiation recall dermatitis (RRD) is an inflammatory skin reaction that develops in a previously quiescent radiation field triggered most commonly by chemotherapy, particularly anthracyclines and taxanes. Radiation-recall dermatitis secondary to antibiotic therapy is quite rare. The patient is 61-year-old female with a history of squamous cell carcinoma of the left breast treated with neoadjuvant carboplatin, paclitaxel, and anthracycline chemotherapy followed by surgery and subsequent whole breast radiation 6040 cGy. Eight years after completion of her radiation she developed diffuse redness of the left breast after two doses of nitrofurantoin taken for a urinary tract infection. On examination, vital signs were stable and she had an erythematous and excoriated rash on her left breast that clinically appeared to be cellulitis. Given her clinical history, coupled with the temporal relationship of starting an antibiotic, strong consideration was given for antibiotic-induced RRD. Nitrofurantoin was discontinued, and the rash resolved completely within several days. This case demonstrates an example of RRD which is the development of an acute inflammatory skin reaction of a previously irradiated area most commonly triggered by chemotherapeutic agents. This case highlights antimicrobial therapy as a rare cause of RRD and underscores the importance of considering RRD in a patient presenting with an acute rash over a previously irradiated area while on antimicrobial therapy

Transitions of PA Safe-house Garden Bed

The non-profit organization, Transitions of PA allows those in crisis, particularly domestic abuse victims, to find support and resources through providing temporary residence at one of Transitions’ three safehouses. We have built a raised garden bed as a therapeutic resource for the Lewisburg safehouse guests, with principles of sustainable gardening in mind. The act of gardening becomes a form of therapy as the connection to the natural elements and intentionality behind sustainable gardening methods have significant mental health benefits. Beyond acting as a therapeutic activity, community gardening has been proven to support social connections and act as a pathway to building support and developing a stronger sense of trust, particularly empowering this community. To ensure optimal accessibility for safehouse guests, educational materials including brochures, outlining the key ways to interact with the garden, and a guidebook for staff, detailing how to sustainably garden, were distributed at the completion of the garden bed. This project encompasses community service, sustainability, and environmental education, all of which have been key to each of our experiences as students

Delay in diagnosis of PD-1 Inhibitor induced Secondary adrenal Insufficiency

Introduction: Immune checkpoint inhibitors including PD-1 inhibitors, were initially approved for the treatment of metastatic melanoma but are now increasingly being used for different types of solid organ malignancies. Despite the important clinical benefits, they are associated with immune-related adverse events. The most critical endocrinopathy associated with PD -1 inhibitor is adrenal insufficiency (AI), which requires prompt diagnosis and management to avoid fatality. Case presentation: We present the case of a 78-year-old woman with colon adenocarcinoma treated with Nivolumab (PD-1 inhibitor) after her pulmonary metastases progressed on chemotherapy. She presented to the hospital with progressive generalized weakness, fatigue, headache, lightheadedness, nausea, myalgia, reduced oral intake. She had 2 prior hospitalizations on account of similar symptoms with workup negative for cancer progression or gastrointestinal obstruction. Her laboratory values showed Na 128mmol/L, K 3.4mmol/L, Cr 0.52mg/dL and blood sugar 42mg/dL. Morning cortisol was low at 2.2µg/dL and ACTH stimulation test was positive. She was diagnosed with AI secondary to Nivolumab use and was started on Hydrocortisone while Nivolumab was discontinued. Conclusion: Immune checkpoint inhibitors have a unique side effect profile of immune-related adverse events, the most critical of which is AI. However, the non-specific manifestations of AI can lead to misdiagnosis or delay in diagnosis. Therefore, it is important for physicians to have high index suspicion for AI in acutely ill patients on PD-1 inhibitors for prompt recognition, diagnosis and treatment of AI which is important to prevent life-threatening adrenal crisis

Oral anticoagulant treatment and the risk of dementia in patients with atrial fibrillation: a population‐based cohort study

Background:We compared the dementia incidence rate between users and nonusers of oral anticoagulants (OACs) in a large cohort of primary care patients with atrial fibrillation.Methods and results:We performed a retrospective study using an Australia-wide primary care data set, MedicineInsight. Patients aged ≥18 years and newly diagnosed with atrial fibrillation between January 1, 2010, and December 31, 2017, and with no recorded history of dementia or stroke were included and followed until December 31, 2018. We applied a propensity score for 1:1 pair matching of baseline covariates and Cox regression for comparing the dementia incidence rates for OAC users and nonusers. Data were analyzed for 18 813 patients with atrial fibrillation (aged 71.9±12.6 years, 47.1% women); 11 419 had a recorded OAC prescription for at least 80% of their follow-up time. During the mean follow-up time of 3.7±2.0 years, 425 patients (2.3%; 95% CI, 2.1%-2.5%) had a documented diagnosis of dementia. After propensity matching, the incidence of dementia was significantly lower in OAC users (hazard ratio [HR], 0.59; 95% CI, 0.44-0.80; PPP=0.002). No significant difference was seen between warfarin users and non-OAC users (HR, 1.08; 95% CI, 0.70-1.70; P=0.723).Conclusions:In patients with atrial fibrillation, direct-acting oral anticoagulant use may result in a lower incidence of dementia compared with treatment with either warfarin or no anticoagulant