19 research outputs found

    Simulation and experiments on friction and wear of diamond: a material for MEMS and NEMS application

    Get PDF
    To date most of the microelectromechanical system (MEMS) devices have been based on silicon. This is due to the technological know-how accumulated on the manipulation, machining and manufacturing of silicon. However, only very few devices involve moving parts. This is because of the rapid wear arising from high friction in these silicon-based systems. Recent tribometric experiments carried out by Gardos on silicon and polycrystalline diamond (PCD) show that this rapid wear is caused by a variety of factors, related both to surface chemistry and cohesive energy density of these likely MEMS bearing materials. In particular, the 1.8-times stronger C-C bond in diamond as opposed to the Si-Si bond in the bulk translates into a more than 104-times difference in wear rates, even though the difference in flexural strength is only 20-times, in hardness 10-times and in fracture toughness 5-times. It also has been shown that the wear rates of silicon and PCD are controlled by high-friction-induced surface cracking, and the friction is controlled by the number of dangling, reconstructed or adsorbate-passivated surface bonds. Therefore, theoretical and tribological characterization of Si and PCD surfaces is essential prior to device fabrication to assure reliable MEMS operation under various atmospheric environments, especially at elevated temperatures. As a part of the rational design and manufacturing of MEMS devices containing moving mechanical assemblies (MEMS-MMA) and especially nanoelectromechanical devices (NEMS), theory and simulation can play an important role. Predicting system properties such as friction and wear, and materials properties such as thermal conductivity is of critical importance for materials and components to be used in MEMS-MMAs. In this paper, we present theoretical studies of friction and wear processes on diamond surfaces using a steady state molecular dynamics method. We studied the atomic friction of the diamond-(100) surface using an extended bond-order-dependent potential for hydrocarbon systems. Unlike traditional empirical potentials, bond order potentials can simulate bond breaking and formation processes. Therefore, it is a natural choice to study surface dynamics under friction and wear. In order to calculate the material properties correctly, we have established a consistent approach to incorporate non-bond interactions into the bond order potentials. We have also developed an easy-to-use software to evaluate the atomic-level friction coefficient for an arbitrary system, and interfaced it into a third-party graphical software

    Cancer therapy shapes the fitness landscape of clonal hematopoiesis.

    Get PDF
    Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal hematopoiesis (CH) and the development of therapy-related myeloid neoplasms (tMNs). We find that mutations are selected differentially based on exposures. Mutations in ASXL1 are enriched in current or former smokers, whereas cancer therapy with radiation, platinum and topoisomerase II inhibitors preferentially selects for mutations in DNA damage response genes (TP53, PPM1D, CHEK2). Sequential sampling provides definitive evidence that DNA damage response clones outcompete other clones when exposed to certain therapies. Among cases in which CH was previously detected, the CH mutation was present at tMN diagnosis. We identify the molecular characteristics of CH that increase risk of tMN. The increasing implementation of clinical sequencing at diagnosis provides an opportunity to identify patients at risk of tMN for prevention strategies

    >

    No full text
    corecore