Anticipating the clinical adoption of regenerative medicine : building institutional readiness in the UK

This perspective paper examines the challenges of implementing regenerative medicine (RM) therapies within hospitals and clinics. Drawing on recent work in the social sciences, the paper highlights dynamics within existing healthcare systems that will present both hindrances and affordances for the implementation of new RM technologies within hospitals and clinics. The paper argues that identifying suitable locations for cell- and gene-therapy treatment centers requires an assessment of their institutional readiness for RM. Some provisional criteria for assessing institutional readiness are outlined, and the paper will suggest that it is necessary to begin developing a program for the phased introduction of RM in the longer ter

The social management of biomedical novelty : Facilitating translation in regenerative medicine

Regenerative medicine (RM) is championed as a potential source of curative treatments for a variety of illnesses, and as a generator of economic wealth and prosperity. Alongside this optimism, however, is a sense of concern that the translation of basic science into useful RM therapies will be laboriously slow due to a range of challenges relating to live tissue handling and manufacturing, regulation, reimbursement and commissioning, and clinical adoption. This paper explores the attempts of stakeholders to overcome these innovation challenges and thus facilitate the emergence of useful RM therapies. The paper uses the notion of innovation niches as an analytical frame. Innovation niches are collectively constructed socio-technical spaces in which a novel technology can be tested and further developed, with the intention of enabling wider adoption. Drawing on primary and secondary data, we explore the motivation for, and the attempted construction of, niches in three domains which are central to the adoption of innovative technologies: the regulatory, the health economic, and the clinical. We illustrate that these niches are collectively constructed via both formal and informal initiatives, and we argue that they reflect wider socio-political trends in the social management of biomedical novelty

Aligning technology and institutional readiness: the adoption of innovation

This paper explores and develops the concept of ‘readiness’ as it relates to the adoption of innovation. In particular, the paper discusses readiness in regard to the notion of ‘technology readiness’ levels, widely used today by both producers and users to monitor and manage emergent innovation. The paper argues that, while useful, this notion needs to be informed by and subsumed within a broader concept of ‘institutional readiness’. The latter is especially important in conceptualising how new technologies are actually adopted in organisational settings. The paper develops a model of institutional readiness that recognises the saliency of technology readiness but which embeds it within a broader sociotechnical framework. This is illustrated with reference to the emerging field of regenerative medici

Media and Repository Support Unit, University of Nebraska–Lincoln Libraries, Annual Report July 2018–June 2019

Increasingly, libraries are recognizing the importance of providing access to the research output of their universities. In a June 10, 2019, news release from the provosts of the Big Ten Academic Alliance (BTAA) titled “Sustaining Values and Scholarship” (available at https://tinyurl.com/yyu94aa9), they state, “The Big Ten Academic Alliance will continue its advocacy for a sustainable and open ecosystem of publication. . . . Collectively, our institutions’ more than 50,000 faculty are supported by over $10 billion (2017) in research funding, and our institutions have similarly invested significantly in our capacity to further our missions to advance knowledge. Together, we produce roughly 15% of the research publications in the United States.” This commitment to open information is reflected in the mission of the Media and Repository Support (MARS) unit of the UNL Libraries. We support the creation and preservation of the scholarly accomplishments of the University of Nebraska–Lincoln by providing an infrastructure for disseminating information and scholarship through Digital Commons (articles, reports, journals, books, and more), Luna (multimedia projects), and Rosetta (data) as well as by providing equipment that students and faculty can check out to capture video and digital images. Through our efforts, the intellectual contributions of UNL are provided, when possible, as open access to disseminate information to as wide a community as possible. We provide advice and consult with researchers and students on scholarly communication issues surrounding open education resources, copyright, options for rights management, publication, and preservation of information in coordination with other faculty and staff in the Libraries. We maintain close contact with staff from Archives & Special Collections to ensure that nondigital information is not overlooked in preservation plans. Faculty within the unit have developed close relationships with the UNL Office of Research, faculty across our campus, and colleagues at the other University of Nebraska campuses (through the University of Nebraska Consortium of Libraries, UNCL)

Investigation of International Space Station Major Constituent Analyzer Anomalous ORU 02 Performance

The Major Constituent Analyzer (MCA) is a mass spectrometer based system that measures the major atmospheric constituents on the International Space Station. In 2011, two MCA ORU 02 analyzer assemblies experienced premature on-orbit failures. These failures were determined to be the result of off-nominal ion source filament performance. Recent product improvements to ORU 02 designed to improve the lifetime of the ion pump also constrained the allowable tuning criteria for the ion source filaments. This presentation describes the filament failures as well as the corrective actions implemented to preclude such failures in the future

Conditional Teleportation of Quantum-Dot Spin States

Among the different platforms for quantum information processing, individual electron spins in semiconductor quantum dots stand out for their long coherence times and potential for scalable fabrication. The past years have witnessed substantial progress in the capabilities of spin qubits. However, coupling between distant electron spins, which is required for quantum error correction, presents a challenge, and this goal remains the focus of intense research. Quantum teleportation is a canonical method to transmit qubit states, but it has not been implemented in quantum-dot spin qubits. Here, we present evidence for quantum teleportation of electron spin qubits in semiconductor quantum dots. Although we have not performed quantum state tomography to definitively assess the teleportation fidelity, our data are consistent with conditional teleportation of spin eigenstates, entanglement swapping, and gate teleportation. Such evidence for all-matter spin-state teleportation underscores the capabilities of exchange-coupled spin qubits for quantum-information transfer.Comment: 12+27 pages, 4+15 figure

Late-spring Turfgrass Establishment without Herbicides

Spring establishment of turfgrass that is managed without herbicides is subject to weed competition, resulting in reduced turfgrass cover. The objective of this experiment was to find an acceptable method for spring turfgrass establishment without the use of pesticides. Thirty-six treatments consisting of three soil amendments combined with three turfgrass species or mixes, and four topdressings or fertilizers in a randomized complete block design were tested. Nutrient-deficient fill soil, fill soil blended with topsoil, and fill soil blended with leaf compost were used as growing media. ‘Firenza’ tall fescue (Schedonorus arundinaceus), an 80/20 mix of ‘Nu Destiny’ kentucky bluegrass (Poa pratensis) and ‘Nexus XD’ perennial ryegrass (Lolium perenne), respectively, and ‘Firefly’ hard fescue (Festuca trachyphylla) were grown with topdressings consisting of biosolids, ash-amended biosolids, 16N–12.2P–3.3K starter fertilizer, and an unfertilized control. The treatments were mowed at 3 inches about once per week. Irrigation was supplied by an overhead sprinkler system (1 inch/week). During the 2010 field study, treatments of tall fescue established in a leaf compost–amended root zone were significantly denser and had a greater percentage of cover (P ≤ 0.05) compared with all other treatments. In 2011, treatments of tall fescue established in fill soil– and leaf compost–amended soils were significantly denser and had a greater percentage of cover (P ≤ 0.05) compared with all other treatments. Kentucky bluegrass/perennial ryegrass and hard fescue treatments had significantly lower (P ≤ 0.05) levels of establishment compared with tall fescue. Topdressing treatments resulted in no significant difference (P ≤ 0.05) in turfgrass establishment

International Wildlife Law : Understanding and Enhancing Its Role in Conservation

We gratefully acknowledge valuable input by Kees Bastmeijer, Sanja Bogojevic, Jennifer Dubrulle, and Han Somsen.Peer reviewedPublisher PD

A nationwide, population‐based study on specialized care for acute heart failure throughout the COVID‐19 pandemic

Aims - The COVID-19 pandemic disrupted the delivery of care for patients with heart failure (HF), leading to fewer HF hospitalizations and increased mortality. However, nationwide data on quality of care and long-term outcomes across the pandemic are scarce.Methods and results - We used data from the National Heart Failure Audit (NHFA) linked to national records for hospitalization and deaths. We compared pre-COVID (2018–2019), COVID (2020), and late/post-COVID (2021–2022) periods. Data for 227 250 patients admitted to hospital with HF were analysed and grouped according to the admission year and the presence of HF with (HFrEF) or without reduced ejection fraction (non-HFrEF). The median age at admission was 81 years (interquartile range 72–88), 55% were men (n = 125 975), 87% were of white ethnicity (n = 102 805), and 51% had HFrEF (n = 116 990). In-hospital management and specialized cardiology care were maintained throughout the pandemic with an increasing percentage of patients discharged on disease-modifying medications over time (p &lt; 0.001). Long-term outcomes improved over time (hazard ratio [HR] 0.92, 95% confidence interval [CI] 0.90–0.95, p &lt; 0.001), mainly driven by a reduction in cardiovascular death. Receiving specialized cardiology care was associated with better long-term outcomes both for those who had HFrEF (HR 0.79, 95% CI 0.77–0.82, p &lt; 0.001) and for those who had non-HFrEF (HR 0.87, 95% CI 0.85–0.90, p &lt; 0.001).Conclusions - Despite the disruption of healthcare systems, the clinical characteristics of patients admitted with HF were similar and the overall standard of care was maintained throughout the pandemic. Long-term survival of patients hospitalized with HF continued to improve after COVID-19, especially for HFrEF.<br/

The Zwicky Transient Facility Observing System

The Zwicky Transient Facility (ZTF) is a synoptic optical survey for high-cadence time-domain astronomy. Building upon the experience and infrastructure of the highly successful Palomar Transient Factory (PTF) team, ZTF will survey more than an order of magnitude faster than PTF in sky area and volume in order to identify rare, rapidly varying optical sources. These sources will include a trove of supernovae, exotic explosive transients, unusual stellar variables, compact binaries, active galactic nuclei, and asteroids. The single-visit depth of 20.4 mag is well matched to spectroscopic follow-up observations, while the co-added images will provide wide sky coverage 1.5 – 2 mag deeper than SDSS. The ZTF survey will cover the entire Northern Sky and revisit fields on timescales of a few hours, providing hundreds of visits per field each year, an unprecedented cadence, as required to detect fast transients and variability. This high-cadence survey is enabled by an observing system based on a new camera having 47 deg^2 field of view – a factor of 6.5 greater than the existing PTF camera - equipped with fast readout electronics, a large, fast exposure shutter, faster telescope and dome drives, and various measures to optimize delivered image quality. Our project has already received an initial procurement of e2v wafer-scale CCDs and we are currently fabricating the camera cryostat. International partners and the NSF committed funds in June 2014 so construction can proceed as planned to commence engineering commissioning in 2016 and begin operations in 2017. Public release will allow broad utilization of these data by the US astronomical community. ZTF will also promote the development of transient and variable science methods in preparation for the seminal first light of LSST