Evaluación formativa y desempeño docente, en los maestros de comunicación de la Unidad de Gestión Educativa Local N°13 – Yauyos, 2020

La presente investigación titulada: Evaluación Formativa y Desempeño Docente, en los maestros de Comunicación de la Unidad de Gestión Educativa Local N°13 – Yauyos, 2020. Tiene el objetivo de determinar la relación entre Evaluación Formativa y Desempeño Docente aplicado por los maestros del área de comunicación en la UGEL Nº13 Yauyos 2020. La investigación desarrollada ha sido clasificada como cuantitativa, no-experimental, aplicativa, descriptiva, transversal y correlacional: ya que no se generan cambios entre las unidades de análisis, los datos se recopilan en un solo momento y se propone determinar el grado de relación entre las variables analizadas y que son aplicadas por los docentes del área de comunicación de la UGEL Nº13 que está ubicada en la provincia de Yauyos, la unidad de análisis fue cada docente que labora en el área de comunicación de la UGEL 13. Como resultado de la investigación se ha encontrado que se concluye que existe relación directa y significativa (Rho de Spearman= 0.564 y Sig. = 0,000), entre la variable Evaluación Formativa aplicada por los docentes y el Desempeño Docente que aplican en el área de comunicación de la UGEL Nº13 Yauyos 2020

Effect of Continuous Positive Airway Pressure on Inflammatory, Antioxidant, and Depression Biomarkers in Women With Obstructive Sleep Apnea: A Randomized Controlled Trial

Study objectives: The effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA. Methods: We conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ? 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor ? (TNF?), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest. Results: Women had a median (25th-75th percentiles) age of 58 (51-65) years, body mass index 33.5 (29.0-38.3) kg/m2, and AHI 33.3 (22.8-49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNF? levels decreased compared to the control group (-0.29 ± 1.1 vs -0.06 ± 0.53, intergroup difference -0.23 [95% CI = -0.03 to -0.50]; p = 0.043). Conclusions: Twelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA

MUNICIPAL ENVIRONMENTAL MANAGEMENT: A PROPOSAL OF INSTRUMENTS FOR DIAGNOSIS OF PUBLIC ENVIRONMENTAL POLICIES IN THE METROPOLITAN AREA OF SALVADOR (MAS)

The aim in this paper is to propose a model for mapping strategies of municipal environmental management for local environmental public policies. To do so, the study adopted a theoretical approach. More specifically, there is discussion on the concepts of public policies and the scenario of the Brazilian municipal environmental management, a brief history of the aspects that involve current national environmental policies. Methodologically, a bibliographical study was carried out through a literature review, which enabled the proposal of instruments for mapping actions and strategies of environmental management in the municipalities of the Metropolitan Area of Salvador (MAS). This theoretical study resulted in the creation of a model form that will be used by empirical researches for mapping the environmental public policies in the MAS City Halls

Senegalese sole transcriptomic profiles in response to different betanodavirus RGNNV/SJNNV reassortant strains

Betanodaviruses are the causative agents of viral nervous necrosis (VNN), a disease that has been reported in more than 40 marine and freshwater fish species worldwide, including Senegalese sole (Solea senegalensis). Based on the variable region T4 (RNA2), betanodaviruses have been classified into 4 genotypes: striped jack nervous necrosis virus (SJNNV), tiger puffer nervous necrosis virus (TPNNV), redspotted grouper nervous necrosis virus (RGNNV), and barfin flounder nervous necrosis virus (BFNNV). Reassortant isolates combining genomic segments from the SJNNV and RGNNV genotypes have been obtained from farmed fish species. The reassortant SpSs-IAusc160.03 (wild type reassortant), with a genome consisting of RGNNV-type RNA1 and SJNNV-type RNA2 segments, is more suited for infecting sole than the parental genotypes, causing 100% mortality by bath challenges. Furthermore, compared with the parental SJNNV genotype, this reassortant strain presents two aminoacidic substitutions (positions 247 and 270) at the extreme C-terminal of the capsid protein, which are involved in host specificity. In the current study, the RNA-Seq technology has been used to determine changes in Senegalese sole transcriptome after infection with the wild type and a less virulent recombinant (rSs160.03247+270) with mutations at aminoacids 247 (serine to alanine) and 270 (serine to asparagine), provoking a 40% decreased mortality. Animals (5 g weight) were distributed into two groups to be intramuscularly injected with the above described viral strains (2x105 TCID50/fish). A negative control group (L15-injected) was also established. Head kidney and nervous tissues (eye+brain) were sampled at 48 post-inoculation. A total of 633 genes were differentially expressed (DEGs) in animals infected with the wild type isolate (358 up-regulated and 49 down-regulated in head kidney; 206 up-regulated and 20 down-regulated in eye+brain), whereas only 393 genes were differentially expressed in animals infected with the mutated isolate (129 up-regulated and 10 down-regulated in head-kidney; 28 up-regulated and 226 down-regulated in eye+brain). The results obtained indicate a 37.9% decrease in the number of DEGs after infection with the mutated reassortant, as well as an inversion in the proportion of genes up/down-regulated in nervous tissue of these animals. In addition, the expression patterns of genes coding for proteins involved in the IFN type I pathway were different in both group of animals. Thus, genes coding for proteins acting as mediators of IFN type I expression (MDA5, LGP2, IRF3, IRF7) and IFN-stimulated genes (ISG15, Mx, PKR, IFI6, IFI35, IFI44, IFIT-1, among others) were up-regulated in animals infected with the wild type reassortant, whereas no-differential expression of these genes was observed in animals infected with the mutated isolate. The different transcriptomic profiles obtained could help to better understand NNV pathogenesis in Senegalese sole, setting up the importance as virulence determinants of aminoacids at positions 247 and 270 within the RNA2 segment. Furthermore, the results obtained permit to identify DEGs that could be used to develop new strategies to control this infectious disease, which has reached high relevance in the aquaculture sector.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Efficacy and safety of robotic spine surgery: systematic review and meta-analysis

Background: Robotic surgery (RS) may offer benefits compared with freehand/conventional surgery (FS) in the treatment of patients with spinal disease. The aim of this study was to evaluate the efficacy and safety of RS versus FS in spinal fusion. Methods: A systematic review and meta-analysis was performed. Data analysis and risk of bias assessment were analysed using REVMAN V5.3. Results: We found 11 randomised clinical trials involving 817 patients (FS: 408, RS: 409). The main diagnosis was degenerative spine disease. SpineAssist, Renaissance (Mazor Robotics), Tianji Robot and TiRobot robots (TINAVI Medical Technologies) were used. Pedicle screw placement within the safety zone (grades A + B according to the Gertzbein and Robbins scale) ranged from 93% to 100% in FS versus 85-100% in RS (relative risk 1.01, 95% CI 1.00-1.03, p = 0.14). Regarding intervention time, the meta-analysis showed a mean difference (MD) of 6.45 min (95% CI -13.59 to 26.49, p = 0.53). Mean hospital stay was MD of -0.36 days (95% CI -1.03 to 0.31, p = 0.30) with no differences between groups. Contradictory results were found regarding fluoroscopy time, although there seems to be a lower radiation dose in RS versus FS (p < 0.05). Regarding safety, the studies included surgical revision frequency. Conclusions: No conclusive results were found suggesting that there are benefits in using RS over FS for spinal fusion. Further research with adequate patient selection, robot type and quality-of-life variables is needed.S

Urticarial lesions in a pregnant woman

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Case Report: A rare instance of acute appendicitis induced by Balantidium Coli parasitic infection

IntroductionAcute appendicitis secondary to parasitic infections is uncommon, being detected in less than 1% of cases. Balantidium coli is a parasite found in pigs and primates with zoonotic potential. To date, only three cases of acute appendicitis induced by this parasite have been documented globally.CaseA 7-year-old female patient, who consumed pork daily, presented to the emergency department with a one-day history of abdominal pain in the lower quadrants, described as colic-like, alongside abdominal distension. Initial abdominal radiography led to a diagnosis of intestinal obstruction. Conservative management without therapeutic response necessitated referral to a higher complexity center. Upon admission, an abdominal computed tomography scan diagnosed acute appendicitis and secondary ileus. During surgical intervention, an appendiceal phlegmon formed by loops of the small intestine was mechanically released, revealing a perforated appendix with extensive fecal peritoneal contamination. Pathological analysis identified an inflammatory infiltrate and the presence of Balantidium coli trophozoites. Medical treatment included Piperacillin-Tazobactam and Metronidazole. The patient was discharged after 10 days of medical treatment.DiscussionAcute appendicitis caused by Balantidium coli is a rare occurrence. It is crucial to identify parasites in pathological samples due to their impact on postoperative management. The close contact between humans and pigs, especially in developing countries, suggests that the prevalence of parasitic infection and colonization by Balantidium coli may be higher than currently recognized. Regarding the identification of this patient's specific exposure, the regular consumption of pork suggests the hypothesis that improper processing is linked to the acquisition of the parasitic infection

(Serie: Conservación y Manejo de Áreas Naturales Protegidas del Altiplano Mexicano)

El Programa de Manejo del Área Natural Protegida Parque Estatal Otomí – Mexica es un instrumento de planeación incluyente, dinámico, flexible y congruente con lo que establece el Código para la Biodiversidad del Estado de México (CBEM) y la Ley General del Equilibrio Ecológico y la Protección al Ambiente (LGEEPA), teniendo como propósito cumplir con los objetivos de su decreto.El Programa de Manejo del Área Natural Protegida Parque Estatal Otomí – Mexica es un instrumento de planeación incluyente, dinámico, flexible y congruente con lo que establece el Código para la Biodiversidad del Estado de México (CBEM) y la Ley General del Equilibrio Ecológico y la Protección al Ambiente (LGEEPA), teniendo como propósito cumplir con los objetivos de su decreto.Gobierno del Estado de México Universidad Autónoma del Estado de México Colegio de Ciencias Geográficas del Estado de México, A. C

Bioenergetic and Autophagic Characterization of Skin Fibroblasts from C9orf72 Patients.

The objective of this study is to describe the alterations occurring during the neurodegenerative process in skin fibroblast cultures from C9orf72 patients. We characterized the oxidative stress, autophagy flux, small ubiquitin-related protein SUMO2/3 levels as well as the mitochondrial function in skin fibroblast cultures from C9orf72 patients. All metabolic and bioenergetic findings were further correlated with gene expression data obtained from RNA sequencing analysis. Fibroblasts from C9orf72 patients showed a 30% reduced expression of C9orf72, ~3-fold increased levels of oxidative stress and impaired mitochondrial function obtained by measuring the enzymatic activities of mitochondrial respiratory chain complexes, specifically of complex III activity. Furthermore, the results also reveal that C9orf72 patients showed an accumulation of p62 protein levels, suggesting the alteration of the autophagy process, and significantly higher protein levels of SUMO2/3 (p = 0.03). Our results provide new data reinforcing that C9orf72 cells suffer from elevated oxidative damage to biomolecules and organelles and from increased protein loads, leading to insufficient autophagy and an increase in SUMOylation processes