Percepção de professoras de ensino médio e fundamental sobre a homofobia na escola em Santa Maria (Rio Grande do Sul/Brasil)

Em pesquisa com escolas estaduais na cidade de Santa Maria (RS), em que entrevistamos 20 professoras, observou-se que não existe a preocupação formal com questões de sexualidade na escola. Discriminações e brincadeiras em torno dos que são ou parecem ser homossexuais são geralmente ignoradas. Professoras entrevistadas relatam grandes dificuldades em tratar o tema homofobia em sala de aula. Os dados indicam que é necessário um trabalho educativo com diretoras de escolas e com orientadoras pedagógicas para que estas sejam sensibilizadas para a questão e possam dar suporte para as professoras que tomam para si a tarefa de abordar temas como a homofobia

Topographical body fat distribution links to amino acid and lipid metabolism in healthy non-obese women.

Visceral adiposity is increasingly recognized as a key condition for the development of obesity related disorders, with the ratio between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) reported as the best correlate of cardiometabolic risk. In this study, using a cohort of 40 obese females (age: 25-45 y, BMI: 28-40 kg/m(2)) under healthy clinical conditions and monitored over a 2 weeks period we examined the relationships between different body composition parameters, estimates of visceral adiposity and blood/urine metabolic profiles. Metabonomics and lipidomics analysis of blood plasma and urine were employed in combination with in vivo quantitation of body composition and abdominal fat distribution using iDXA and computerized tomography. Of the various visceral fat estimates, VAT/SAT and VAT/total abdominal fat ratios exhibited significant associations with regio-specific body lean and fat composition. The integration of these visceral fat estimates with metabolic profiles of blood and urine described a distinct amino acid, diacyl and ether phospholipid phenotype in women with higher visceral fat. Metabolites important in predicting visceral fat adiposity as assessed by Random forest analysis highlighted 7 most robust markers, including tyrosine, glutamine, PC-O 44∶6, PC-O 44∶4, PC-O 42∶4, PC-O 40∶4, and PC-O 40∶3 lipid species. Unexpectedly, the visceral fat associated inflammatory profiles were shown to be highly influenced by inter-days and between-subject variations. Nevertheless, the visceral fat associated amino acid and lipid signature is proposed to be further validated for future patient stratification and cardiometabolic health diagnostics

Results of the Brazilian Osteosarcoma Treatment Group studies III and IV: Prognostic factors and impact on survival

Purpose To evaluate the impact of chemotherapy and surgery on the outcome of osteosarcoma (OS) of the extremities and to identify prognostic factors in Brazilian patients.Patients and Methods A total of 225 patients with metastatic and nonmetastatic OS of the extremities were enrolled and assessed in two consecutive studies designed and implemented by the Brazilian Osteosarcoma Treatment Group.Results the 5-year survival and event-free survival rates for the 209 assessable patients were 50.1% and 39%, respectively; for the 178 patients with nonmetastatic disease at diagnosis, the rates were 60.5% and 45.5%, respectively. the multivariate analysis showed that the following variables were associated with a shorter survival: metastases at diagnosis (P < .001), necrosis grades 1 and 2 (P = .046), and tumor size (P = .0071).Conclusion the overall 5- and 10-year survival rates were lower than the rates reported in North American and European trials. A pattern of advanced disease at diagnosis was often present, with a high proportion of patients having metastases (20.8%) and large tumor size (42.9%). However, these features were not necessarily associated with longer duration of prediagnostic symptoms. These findings were considered in the strategic planning of the current Brazilian cooperative study, with the aim of improving survival and quality of life of a large number of patients with OS.Universidade Federal de São Paulo, Inst Oncol Pediat, Grp Apolo Adolescente & Crianca Com Canc, BR-04023062 São Paulo, BrazilHosp Canc, Dept Pediat, São Paulo, BrazilUniv São Paulo, Hosp Clin São Paulo, Fac Med, São Paulo, BrazilSanta Casa Misericordia, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthopaed, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, São Paulo, BrazilHosp Clin Porto Alegre, Porto Alegre, RS, BrazilChildrens Hosp Los Angeles, Los Angeles, CA 90027 USAUniversidade Federal de São Paulo, Inst Oncol Pediat, Grp Apolo Adolescente & Crianca Com Canc, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Orthopaed, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pathol, São Paulo, BrazilWeb of Scienc