Palladium(0)-Catalyzed Arylative Dearomatization of Phenols

The palladium-catalyzed arylative dearomatization of phenols to yield spirocyclohexadienone products in good to excellent yields has been developed. Preliminary results demonstrate that the formation of the spirocyclic all-carbon quaternary center can be accomplished with high levels of enantiocontrol (up to 91% ee).National Institutes of Health (U.S.) (Grant GM46059)National Science Foundation (U.S.) (Grant CHE 9808061)National Science Foundation (U.S.) (Grant DBI 9729592