Modeling dust emission in PN IC 418

We investigated the infrared (IR) dust emission from PN IC 418, using a detailed model controlled by a previous determination of the stellar properties and the characteristics of the photoionized nebula, keeping as free parameters the dust types, amounts and distributions relative to the distance of the central star. The model includes the ionized region and the neutral region beyond the recombination front (Photodissociation region, or PDR), where the [OI] and [CII] IR lines are formed. We succeeded in reproducing the observed infrared emission from 2 to 200~\mm. The global energy budget is fitted by summing up contributions from big grains of amorphous carbon located in the neutral region and small graphite grains located in the ionized region (closer to the central star). Two emission features seen at 11.5 and 30~\mm are also reproduced by assuming them to be due to silicon carbide (SiC) and magnesium and iron sulfides (Mg$_x$Fe$_{1-x}$S), respectively. For this, we needed to consider ellipsoidal shapes for the grains to reproduce the wavelength distribution of the features. Some elements are depleted in the gaseous phase: Mg, Si, and S have sub-solar abundances (-0.5 dex below solar by mass), while the abundance of C+N+O+Ne by mass is close to solar. Adding the abundances of the elements present in the dusty and gaseous forms leads to values closer to but not higher than solar, confirming that the identification of the feature carriers is plausible. Iron is strongly depleted (3 dex below solar) and the small amount present in dust in our model is far from being enough to recover the solar value. A remaining feature is found as a residue of the fitting process, between 12 and 25~\mm, for which we do not have identification.Comment: Accepted for publication in Astronomy & Astrophysics. V2: adding reference

Histone Mutants Separate R Loop Formation from Genome Instability Induction

R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability. R loops containing single-stranded DNA (ssDNA), versus RNA-DNA hybrids alone, were demonstrated using ssDNA-specific human AID and bisulfite. Notably, they are similar size regardless of whether or not they induce genome instability. Contrary to mutants causing R loop-mediated instability, these histone mutants do not accumulate H3 serine-10 phosphate (H3S10-P). We propose a two-step mechanism in which, first, an altered chromatin facilitates R loops, and second, chromatin is modified, including H3S10-P, as a requisite for compromising genome integrity. Consistently, these histone mutations suppress the high H3S10 phosphorylation and genomic instability of hpr1 and sen1 mutants. Therefore, contrary to what was previously believed, R loops do not cause genome instability by themselves.European Research Council ERC2014 AdG669898Ministerio de Economía y Competitividad BFU2013-42918-P, BFU2016-75058-

Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox model

This is the peer reviewed version of the following article: “Alarcón-Soto, Y, Langohr K., Fehér, C., García, F., and Gómez, G. (2018) Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox Model.Biometrical journal, December 13th ”which has been published in final form at [doi: 10.1002/bimj.201700291]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.We present a method to fit a mixed effects Cox model with interval-censored data. Our proposal is based on a multiple imputation approach that uses the truncated Weibull distribution to replace the interval-censored data by imputed survival times and then uses established mixed effects Cox methods for right-censored data. Interval-censored data were encountered in a database corresponding to a recompilation of retrospective data from eight analytical treatment interruption (ATI) studies in 158 human immunodeficiency virus (HIV) positive combination antiretroviral treatment (cART) suppressed individuals. The main variable of interest is the time to viral rebound, which is defined as the increase of serum viral load (VL) to detectable levels in a patient with previously undetectable VL, as a consequence of the interruption of cART. Another aspect of interest of the analysis is to consider the fact that the data come from different studies based on different grounds and that we have several assessments on the same patient. In order to handle this extra variability, we frame the problem into a mixed effects Cox model that considers a random intercept per subject as well as correlated random intercept and slope for pre-cART VL per study. Our procedure has been implemented in R using two packages: truncdist and coxme, and can be applied to any data set that presents both interval-censored survival times and a grouped data structure that could be treated as a random effect in a regression model. The properties of the parameter estimators obtained with our proposed method are addressed through a simulation study.Peer ReviewedPostprint (author's final draft

Adaptación de la metodología al Espacio Europeo de Educación Superior. Análisis de la opinión de los alumnos

Tradicionalmente la asignatura “Métodos Cuantitativos para la Economía y la Empresa” seguía una metodología basada en la conocida lección magistral y con un temido examen final como única evaluación. Con el objetivo de adaptar dicha metodología al Espacio Europeo de Educación Superior, se han propuesto prácticas que faciliten el proceso de autoaprendizaje así como un nuevo sistema de evaluación continuo. El presente trabajo se centra en el análisis de la opinión del alumno, recogida mediante una encuesta, sobre la nueva metodología y los materiales elaborados

Laser radiation as an adjunct to nonsurgical treatment of periodontal disease.

Peer Reviewe

Seroprevalencia de hepatitis virales en pacientes programados para artroplastia de sustitución de cadera y rodilla

Se estudiaron 102 pacientes consecutivos propuestos para artoplastia de sustitución de cadera o rodilla entre julio de 1998 y mayo de 2000 para conocer la prevalencia de marcadores serológicos de los virus de la hepatitis B (VHB) y C (VHC), y su asociación con factores de riesgo o predictivos prequirúrgicos. La edad media fue de 70±6 años, con predominio femenino. La prevalencia de antígeno de superficie del VHB fue de 1,96%, la de anticuerpo anti-core del mismo virus fue del 26,47%, y no se observó ningún marcador positivo frente al VHC. Ningún factor de riesgo o predictivo estudiado presentó diferencias significativas según la positividad de los marcadores, excepto la hepatopatía previa. La cohorte de pacientes estudiados, representativa de los pacientes programados para esta cirugía en nuestro medio, no presenta un mayor riesgo de transmisión de hepatitis vírica, aunque sí mayor contacto con el VHB que otras poblaciones de menor edad.One hundred and two consecutive patients scheduled for hip or knee arthroplasty were studied from July 1998 to May 2000, to detect the prevalence of serologic markets of B (HBV) and C (HCV) hepatitis viruses, and its preoperative association with rink or predictive factors. Mean age was 70±6 years, and women predominated. Prevalence of HBV surface antigen was 1,96%, that of HBV anti-core antibody was 26,47%, and no positive markers were observed against HCV. None of variables evaluated as risk or predictive factors showed significant association with presence of serum markers, except previous liver disease. The studied group of patients, representative of the scheduled patients for total hip or knee arthroplasty in our area, does not suggest a higher risk of viral hepatitis transmission. However, a higher number of contacts with HBV than in younger populations have been observed in this group

Effects of Non-Circular Motions on Azimuthal Color Gradients

Assuming that density waves trigger star formation, and that young stars preserve the velocity components of the molecular gas where they are born, we analyze the effects that non-circular gas orbits have on color gradients across spiral arms. We try two approaches, one involving semi-analytical solutions for spiral shocks, and another with magnetohydrodynamic (MHD) numerical simulation data. We find that, if non-circular motions are ignored, the comparison between observed color gradients and stellar population synthesis models would in principle yield pattern speed values that are systematically too high for regions inside corotation, with the difference between the real and the measured pattern speeds increasing with decreasing radius. On the other hand, image processing and pixel averaging result in systematically lower measured spiral pattern speed values, regardless of the kinematics of stellar orbits. The net effect is that roughly the correct pattern speeds are recovered, although the trend of higher measured $\Omega_p$ at lower radii (as expected when non-circular motions exist but are neglected) should still be observed. We examine the Martinez-Garcia et al. (2009) photometric data and confirm that this is indeed the case. The comparison of the size of the systematic pattern speed offset in the data with the predictions of the semi-analytical and MHD models corroborates that spirals are more likely to end at Outer Lindblad Resonance, as these authors had already found.Comment: 32 pages, 15 figures, accepted to Ap

Discurso de investidura como Doctor Honoris Causa del Prof. C. Tiao

Investido Doctor Honoris Causa en el acto del día de la Universidad del curso 02/0

Forming first-ranked early-type galaxies through hierarchical dissipationless merging

We have developed a computationally competitive N-body model of a previrialized aggregation of galaxies in a flat LambdaCDM universe to assess the role of the multiple mergers that take place during the formation stage of such systems in the configuration of the remnants assembled at their centres. An analysis of a suite of 48 simulations of low-mass forming groups (of about 1E13 solar masses) demonstrates that the gravitational dynamics involved in their hierarchical collapse is capable of creating realistic first-ranked galaxies without the aid of dissipative processes. Our simulations indicate that the brightest group galaxies (BGGs) constitute a distinct population from other group members, sketching a scenario in which the assembly path of these objects is dictated largely by the formation of their host system. We detect significant differences in the distribution of Sersic indices and total magnitudes, as well as a luminosity gap between BGGs and the next brightest galaxy that is positively correlated with the total luminosity of the parent group. Such gaps arise from both the grow of BGGs at the expense of lesser companions and the decrease in the relevance of second-ranked objects in equal measure. This results in a dearth of intermediate-mass galaxies which explains the characteristic central dip detected in their luminosity functions in dynamically young galaxy aggregations. The fact that the basic global properties of our BGGs define a thin mass fundamental plane strikingly similar to that followed giant early-type galaxies in the local universe reinforces confidence in the results obtained.Comment: 25 pages, 14 figures, 3 tables. Accepted to MNRA