Self-production of free access audiovisual material for university teaching

Este proyecto busca dotar a los estudiantes universitarios de las herramientas necesarias para poder crear y postproducir material audiovisual propio. En particular, fomenta la utilización de software libre que permita su utilización sin necesidad de realizar pago por licencia. De esta forma, se busca fomentar la autonomía e iniciativa del estudiante y sus posibilidades de colaboración con otros compañeros y el resto de actores académicos. También dota a su currículum de mayores posibilidades para la transferencia de su formación en entornos laborales fuera de la Universidad.Depto. de Física TeóricaDepto. de Física de MaterialesFac. de Ciencias FísicasFALSEsubmitte

Lymphoplasmacytic lymphoma associated with diffuse large B-cell lymphoma: Progression or divergent evolution?

AimLymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell-neoplasm with involvement of the bone marrow. At least 90% of LPLs carry MYD88-L265P mutation and some of them (~10%) transform into diffuse large B-cell-lymphoma (DLBCL).Material and methodsOver the past 15 years we have collected 7 cases where the both LPL and DLBCL were diagnosed in the same patient. Clinical records, analytical data and histopathological specimens were reviewed. FISH studies on paraffin-embedded tissue for MYC, BCL2 and BCL6 genes were performed, as well as MYD88-L265P mutation and IGH rearrangement analysis by PCR. A mutational study was done by massive next generation sequencing (NGS).ResultsThere were 4 women and 3 men between 36-91 years of age. Diagnoses were made simultaneously in 4 patients. In two cases the LPL appeared before the DLBCL and in the remaining case the high-grade component was discovered 5 years before the LPL. In 6 cases both samples shared the MYD88-L265P mutation. IGH rearrangement analysis showed overlapping features in two of 6 cases tested. Mutational study was evaluable in three cases for both samples showing shared and divergent mutations.ConclusionsThese data suggest different mechanisms of DLBCL development in LPL patients