La rejilla horizontal antipulgar según técnica de Mollin modificada

El presente trabajo presenta un aparato auxiliar fijo para evitar el hábito de succión digital, descrito por el Dr. Mollin (USA) y modificado por el Dr. J. M. Salagnac (Francia). Consiste en una rejilla de disposición horizontal que además de eliminar el hábito de succión, ayuda en la corrección de las alteraciones dentarias ya establecidas y se compara con otros sistemas mecánicos utilizados habitualmente

Metodología para estudios histológicos pulpares en ratas

La pulpotomía es uno de los tratamientos más frecuentes en odontopediatría, siendo hasta ahora el formocresol el fármaco más frecuentemente utilizado, pero su uso está siendo discutido debido a su potencial toxicidad. Existen distintas alternativas; agentes como el glutaraldehído y el sulfato férrico, materiales biocompatibles como el colágeno, hueso liofilizado y proteínas morfogenéticas formadoras de hueso, o técnicas como la electrocoagulación o la aplicación de láser. Por ello, son fundamentales, no sólo los estudios clínicos y radiológicos, sino también los estudios histológicos que nos muestran la respuesta del tejido pulpar ante la aplicación de los distintos materiales o técnicas. Estos estudios se realizan con diferentes especies animales y a su vez con distinta metodología. El objetivo de este trabajo ha sido describir una técnica para realizar estudios pulpares en molares de rata y estudiar la respuesta histológica que se observa en una exposición pulpar con la aplicación posterior de un agente como el hueso liofilizado. Nuestros resultados destacan que la técnica desarrollada para las exposiciones pulpares en ratas es adecuada y reproducible en otros estudios sobre el efecto de los distintos fármacos en el tejido pulpar

Estado actual de las pulpotomías con electrocoagulación

En la actualidad son varios los fármacos que se han utilizado para las pulpotornías,siendo el formocresol el más difundido. No obstante su uso está discutido por sus efectos tóxicos, su potencial mutagénico y carcinogénico y su respuesta inmunológica. Por este motivo la investigación se ha encaminado a la búsqueda de técnicas o fármacos menos tóxicos. Se pensó en la electrocoagulación como método alternativo a la aplicación de fármacos. Actualmente son varios los estudios que se han llevado a cabo para evaluar los resultados clínicos, radiológicos e histológicos de las pulpotomías con electrocoagulación

Trace Elements Distribution in Red Soils under Semiarid Mediterranean Environment

This study states the potential trace elements (TE’s) content of red soils located at the centre region of Spain, characterized by low rainfall and slight acidity over prolonged weathering periods. For this purpose, three soil profiles from a catena were described, sampled and analyzed. The most notable characteristics are the low organic matter content and the predominantly acidic pH. Illite and kaolinite are the predominant clay minerals. The fertility of the soils is sufficient to provide most of the nutrients required, with very suitable potassium levels. The geochemical characters of this soil are: only few elements remain almost invariable across the profiles and over time, however the majority of them were directly linked with the clay content. These soils are characterized by relatively low levels of some trace elements such as Sr (64.35 mg?kg–1), Ba (303.67 mg?kg–1) and Sc (13.14 mg?kg–1); high levels of other trace elements such as V (103.92 mg?kg–1), Cr (79.9 mg?kg–1), Cu (15.18 mg?kg–1), Hf (10.26 mg?kg–1), Ni (38 mg?kg–1) and Zr (337 mg?kg–1); while the levels for rare earth elements (REE’s) such as La (48.36 mg?kg–1), Ce (95.07 mg?kg–1), Th (13.33 mg?kg–1) and Nd (42.65 mg?kg–1) are significantly high. The distribution of mayor and trace elements was directly re- lated to weathering processes, parent material and anthropogenic activities

Study of rotational splittings in δ Scuti stars using pattern finding techniques

ARB, JPG, and RG acknowledge funding support from Spanish public funds for research from project ESP2017-87676-C5-5-R from the `Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion', from project PID2019-107061GB-C63 from the `Programas Estatales de Generacion de Conocimiento y Fortalecimiento Cientifico y Tecnologico del Sistema de I+D+i y de I+D + i Orientada a los Retos de la Sociedad', and from the State Agency for Research through the `Center of Excellence Severo Ochoa' award to the Instituto de Astrofisica de Andalucia (SEV-2017-0709), all from the Spanish Ministry of Science, Innovation and Universities. ARB also acknowledges funding support from project PRE2018084322 from the `Programa Estatal de Promocion del Talento y su Empleabilidad del Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2013-2016' of the Spanish Ministry of Science, Innovation and Universities. AGHacknowledges funding support from Spanish public funds for research under projects ESP2017-87676-2-2 the SpanishMinistry of Science and Education, and from `European Regional Development Fund/Junta de Andalucia-Consejeria de Economia y Conocimiento' under project E-FQM-041-UGR18 by Universidad de Granada. JCS acknowledges funding support from Spanish public funds for research under projects PID2019-107061GB-C63 and ESP201787676-2-2, and from project RYC-2012-09913 under the `Ramon y Cajal' program of the Spanish Ministry of Science and Education.Detecting and understanding rotation in stellar interiors is nowadays one of the unsolved problems in stellar physics. Asteroseismology has been able to provide insights on rotation for the Sun, solar-like stars, and compact objects like white dwarfs. However, this is still very difficult for intermediate-mass stars. These stars are moderate-to-rapid rotators. Rotation splits and shifts the oscillation modes, which makes the oscillation spectrum more complex and harder to interpret. Here we study the oscillation patterns of a sample of benchmark delta Sct stars belonging to eclipsing binary systems with the objective of finding the frequency spacing related to the rotational splitting (delta r). For this task, we combine three techniques: the Fourier transform, the autocorrelation function, and the histogram of frequency differences. The last two showed a similar behaviour. For most of the stars, it was necessary to determine the large separation (Delta nu) prior to spot delta r. This is the first time we may clearly state that one of the periodicities present in the p modes oscillation spectra of delta Sct stars corresponds to the rotational splitting. This is true independent of the stellar rotation rate. These promising results pave the way to finding a robust methodology to determine rotational splittings from the oscillation spectra of delta Sct stars and, thus, understanding the rotational profile of intermediate-mass pulsating stars.Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion ESP2017-87676-C5-5-RProgramas Estatales de Generacion de Conocimiento y Fortalecimiento Cientifico y Tecnologico del Sistema de I+D+i y de I+D + i Orientada a los Retos de la Sociedad PID2019-107061GB-C63State Agency for Research through the `Center of Excellence Severo Ochoa' SEV-2017-0709Spanish Ministry of Science, Innovation and UniversitiesPrograma Estatal de Promocion del Talento y su Empleabilidad del Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2013-2016' of the Spanish Ministry of Science, Innovation and Universities PRE2018084322Spanish Government ESP2017-87676-2-2European Regional Development Fund/Junta de Andalucia-Consejeria de Economia y Conocimientoby Universidad de Granada E-FQM-041-UGR18Spanish public funds for research PID2019-107061GB-C63 ESP201787676-2-2Spanish Government RYC-2012-0991

Impact of a tire fire accident on soil pollution and the use of clay minerals as natural geo-indicators

Following the occurrence of a fire at a tire landfill in the surrounding area of Madrid City (Spain), polycyclic aromatic hydrocarbons (PAHs) and trace elements present in soils were analyzed to assess the impact of the fire. The capacity of the soils’ clay mineral fraction to reflect this air pollution incident was studied. Fourteen soil samples were collected at different distances under the smoke plume, and they were subjected to high-performance liquid chromatography–photodiode array detection, inductively coupled plasma mass spectrometry and X-ray diffraction analyses. Clay minerals content showed a strong correlation with the pollutants potentially released in the tire fire, acenaphthene, pyrene, benzo(a)pyrene and benzo(a)fluoranthene. Trace metals Zn and Se were related to the proximity of the tire fire without any relationship with clay minerals content. This work suggests the use of natural clay minerals as potential PAHs geo-indicators in response to air pollution, complementary to current air and biological analysesThis work has been economically supported by the Ministry of Economy and Competitiveness of Spain, Project AGL2016-78490-

Aspectos legales en casos de malos tratos en odontopediatría: presentación de un caso clínico

Teniendo en cuenta el hecho de que ha sido comprobado un incremento en el número de informes sobre malos tratos infantiles que presentan los odontoestomatólogos una vez han recibido información sobre el tema, este artículo pretende informar y animar a dichos profesionales para que entren a formar parte de los equipos interdisciplinarios que trabajan en la identificación de casos para su posterior resolúción

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio