Orbital Hemangiopericytoma

KEY WORDS : Hemangiopericytoma, orbit, proptosi

Hepatic pinworm infestation misdiagnosed as a liver metastasis in a patient with colonic adenocarcinoma

An extra-intestinal infestation of Enterobius vermicularis (pinworm) is uncommon. We present a case of hepatic infestation of pinworm in a 57-year-old woman, misdiagnosed as a colorectal adenocarcinoma metastasis. The route of migration from the intestine to the liver is not well established but the most plausible route seems to be hematogenous. In concordance with previously published cases, the hepatic pinworm infestation is usually localised superficially in the right liver lobe. Hence solitary lesions in this location detected radiologically should be interpreted carefully. Additionally, the serum CEA level could be useful to distinguish pinworm from malignancy

Induction of Anti-Tumor Immune Responses by Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE in a Murine Model of a Human Neuroendocrine Tumor

Peptide receptor radionuclide therapy (PRRT) is a relatively new mode of internally targeted radiotherapy currently in clinical trials. In PRRT, ionizing radioisotopes conjugated to somatostatin analogues are targeted to neuroendocrine tumors (NETs) via somatostatin receptors. Despite promising clinical results, very little is known about the mechanism of tumor control. By using NCI-H727 cells in an in vivo murine xenograft model of human NETs, we showed that 177Lu-DOTATATE PRRT led to increased infiltration of CD86+ antigen presenting cells into tumor tissue. We also found that following treatment with PRRT, there was significantly increased tumor infiltration by CD49b+/FasL+ NK cells potentially capable of tumor killing. Further investigation into the immunomodulatory effects of PRRT will be essential in improving treatment efficacy