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18 research outputs found
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
Author
Bradley W. D.
Cao R.
+13 more
Garapaty-Rao S.
Knutson S. K.
Knutson S. K.
Knutson S. K.
Konze K. D.
Kuzmichev A.
Nasveschuk C. G.
Ntziachristos P.
Qi W.
Simon J. A.
Sneeringer C. J.
Verma S. K.
Wang S.
Publication venue
'American Chemical Society (ACS)'
Publication date
Field of study
No full text
Crossref
Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2
Author
Brameld K. A.
Cheng Y.
+22 more
Dahlgard M.
Diaz E.
Gusakova N. N.
Kleer C. G.
Knutson S. K.
Konze K. D.
Majer C. R.
Margueron R.
McCabe M. T.
McCabe M. T.
Qi W.
Shivani Garapaty-Rao S.
Shoichet B. K.
Shultz M. D.
Shultz M. D.
Sneeringer C. J.
Sweis R. F.
Thomas V. H.
Varambally S.
Verma S. K.
Wigle T. J.
Yap D. B.
Publication venue
'American Chemical Society (ACS)'
Publication date
Field of study
No full text
Crossref
Recent Progress in the Discovery of Epigenetic Inhibitors for the Treatment of Cancer
Author
AD Ferguson
American Cancer Society
+40 more
CB Wilson
CG Kleer
CJ Sneeringer
DB Yap
F Liu
F Liu
JA Simon
KM Bernt
L Pasqualucci
M Allan
M Takawa
M Vedadi
MT McCabe
MT McCabe
N Tsankova
N Wagener
PA Jones
PK Chiang
Q Feng
RA Copeland
RA Copeland
RD Morin
RD Morin
RT Borchardt
S Garapaty-Rao
S Knutson
S Varambally
S Varambally
SC Dillon
SK Verma
SK Verma
SR Daigle
SR Daigle
T Ernst
T Kouzarides
TB Miranda
TJ Wigle
W Kim
W Qi
X Cheng
Publication venue
'Springer Science and Business Media LLC'
Publication date
Field of study
No full text
Crossref
Versatile and efficient chromatin pull-down methodology based on DNA triple helix formation
Author
A Finley
A Jain
+37 more
AE Kliszczak
BM Sirbu
CI Wang
D Vasudevan
E Brunet
EYD Chua
F Coin
F Pourfarzad
G Felsenfeld
HR Drew
J Déjardin
JM Antão
JS Godde
JS Sun
K Luger
M Duca
M Takasugi
MA Zabidi
MD Sørensen
MS Hayden
N Alonso
PB Dervan
PE Nielsen
PM Brown
PN Dyer
PT Lowary
Q Zhang
R Alam
R Hamamoto
S Garapaty-Rao
S Ide
T Ito
T Suzuki
TA Hagerman
X Shen
Y Li
Y Luo
Publication venue
'Springer Science and Business Media LLC'
Publication date
Field of study
No full text
Crossref
Expression of enhancer of zeste homolog 2 (EZH2) protein in histiocytic and dendritic cell neoplasms with evidence for p-ERK1/2-related, but not MYC- or p-STAT3-related cell signaling
Author
A Rjoop
A-M Bubolz
+49 more
B Shi
Christopher Fletcher
CR Majer
David M Dorfman
DM Dorfman
DP O'Malley
E Di Liso
G Badalian-Very
G Egger
G Nikoloski
H Go
H Idbaih
H Makishima
H Xiong
J Haroche
J Score
J Yan
J Yan
JA Simon
Jason L Hornick
Jie Xu
JL Vaughn
L Herviou
M Ceribelli
M Shi
MT McCabe
NA Brown
P Guglielmelli
P Ntziachristos
Q Liu
R Bejar
R Chakraborty
RD Morin
S Fujii
S Fujii
S Garapaty-Rao
S Wee
SH Swerdlow
ST Lee
T Ernst
T Jiang
W Beguelin
W Huang
W Qi
X Tian
Xuejun Tian
Y Fedoriw
YW Lin
Z Gatalica
Publication venue
'Springer Science and Business Media LLC'
Publication date
Field of study
No full text
Crossref
Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2
Author
Bodor C.
Brooke M. Swalm
+35 more
Cao R.
Copeland R. A.
Dirk L. M.
Garapaty-Rao S.
Heike Keilhack
Hodis E.
Jesse J. Smith
Kevin W. Kuntz
Knutson S. K.
Konze K. D.
Kuzmichev A.
Lei Jin
Lohr J. G.
Majer C. R.
Margaret Porter Scott
Margueron R.
McCabe M. T.
McCabe M. T.
McGinty R. K.
Mikel P. Moyer
Morin R. D.
Morin R. D.
Mrksich M.
Natalie M. Warholic
Patnaik D.
Qi W.
Robert A. Copeland
Roy M. Pollock
Sarah K. Knutson
Shahbazian M. D.
Sneeringer C. J.
Tim J. Wigle
Wang M.
Wigle T. J.
Yap D. B.
Publication venue
'American Chemical Society (ACS)'
Publication date
Field of study
No full text
Crossref
Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
Author
A Chase
A Q Hassan
+45 more
AD Ferguson
C G Paris
C Holohan
CJ Sneeringer
CM Emery
D King
D Ruddy
DB Yap
DR Kipp
F Shen
GR Hoffman
H M Chan
H Wu
H Zhai
J Harari
J Korn
J Wehrle
JA Simon
JD Jaffe
K Helin
LA Boyer
M Azam
M Korpal
M Lira
M Vedadi
MT McCabe
N Keen
R Margueron
RD Morin
S Antonysamy
S Garapaty-Rao
SC Mack
SK Knutson
SK Knutson
SK Knutson
T Rejtar
TI Lee
V Gibaja
V Saenz-Vash
W Beguelin
W Kim
W Qi
W Qi
X Shen
Z Yu
Publication venue
'Springer Science and Business Media LLC'
Publication date
Field of study
No full text
Crossref
Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
Author
Anglin J. L.
Anqi Ma
+66 more
Antignano F.
Arrowsmith C. H.
Ashutosh Tripathy
Beck D. B.
Beguelin W.
Bernstein B. E.
Chang Y.
Chen X.
Cheryl H. Arrowsmith
Choi J. Y.
Copeland R. A.
Couture J. F.
Daigle S. R.
Daigle S. R.
Fang J.
Fengling Li
Ferguson A. D.
Garapaty-Rao S.
He Y.
Helin K.
J. Martin Herold
Jacqueline L. Norris
Jenuwein T.
Jian Jin
Knutson S. K.
Knutson S. K.
Konze K. D.
Konze K. D.
Kouzarides T.
Kubicek S.
Kyle V. Butler
Lehnertz B.
Liu F.
Liu F.
Liu F.
Liu F.
Liu F.
Martin C.
Masoud Vedadi
McCabe M. T.
Min J.
Nasveschuk C. G.
Nishioka K.
Peter J. Brown
Qi W.
Rachel M. Bleich
Senisterra G.
Shi X.
Siarheyeva A.
Stephen V. Frye
Sweis R. F.
Takawa M.
Vedadi M.
Verma S. K.
Victoria Korboukh
Wenyu Yu
Wigle T. J.
William P. Janzen
Williams D. E.
Xiao B.
Yang F.
Yao Y.
Yost J. M.
Yu W.
Yuan Y.
Zheng W.
Publication venue
'American Chemical Society (ACS)'
Publication date
Field of study
No full text
Crossref
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
Author
AA Alizadeh
AA George
+55 more
AI Badeaux
Alejandra Raimondi
AV Budanov
B Chapuy
Bruce A. Littlefield
C Furusawa
Christine R. Klaus
CP Hans
Dorothy Iwanowicz
E Ayroldi
G Lenz
G Lenz
G Schlossmacher
Heike Keilhack
HP Rutz
HP Rutz
Jan Peter Tuckermann
Jesse J. Smith
JG Lohr
KD Konze
Kevin W. Kuntz
L. Danielle Johnston
LJ Nastoupil
M Schenone
Margaret Porter-Scott
Mikel P. Moyer
MT McCabe
N Niitsu
Natalie M. Warholic
PJ Barrett-Lee
R van Horssen
RA Copeland
RA Copeland
RD Morin
RD Morin
RH Oakley
Robert A. Copeland
Roy M. Pollock
RV Sionov
S Garapaty-Rao
S John
S Ramamoorthy
SA Maxwell
Sarah K. Knutson
SK Knutson
SK Knutson
SK Knutson
SR Daigle
T Van Bogaert
Tim J. Wigle
TJ Wigle
W Beguelin
W Qi
WK Clements
WW Choi
Publication venue
'Public Library of Science (PLoS)'
Publication date
Field of study
No full text
Crossref
Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma
Author
A Basu
A Hauschild
+75 more
A Prahallad
A Subramanian
Aaron J. Mackey
AJ Thomas
Alex F. Koeppel
B Rubinfeld
B Sapkota
Brian J. Capaldo
C Hertzman Johansson
CH Kugel
CL Slingluff
CM Johannessen
CM Johannessen
CM Teven
Craig L. Slingluff
Daniel Gioeli
DB Solit
Devin Roller
DJ Konieczkowski
E Shtivelman
EM Van Allen
Emanuel F. Petricoin
EV Abel
EW Joseph
F Diella
FS Lee
FS Lee
G Federici
G Improta
GK Smyth
GV Yamshchikov
I Rebay
IA Adzhubei
J Barretina
J Müller
JA Curtin
JN Søndergaard
K Zhang
Keiran Smalley
KR Molhoek
KR Molhoek
KT Flaherty
KT Flaherty
M Holderfield
M Soda
MA Held
Mark J. Axelrod
Michael J. Weber
MS Lawrence
N Delcourt
N Wagle
OM Eichhoff
P Du
P Khatri
PB Chapman
PI Poulikakos
PLJ de Keizer
Q Li
R Halaban
R Halaban
R Suzuki
RC Gentleman
S Chandarlapaty
S Draghici
S Draghici
S Garapaty-Rao
S Xu
Stefan Bekiranov
T Oike
T Strub
TL Darrow
U Levin-Gromiko
X Shen
Z Ji
Z-J Liu
Publication venue
'Public Library of Science (PLoS)'
Publication date
Field of study
No full text
Crossref
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