Modules identification in gene positive networks of hepatocellular carcinoma using pearson agglomerative method and Pearson cohesion coupling modularity

In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes. A Pearson agglomerative clustering algorithm is employed to build a clustering tree, where dotted lines cut the tree from bottom to top leading to a number of subsets of the modules. In order to achieve better module partitions, the Pearson correlation coefficient modularity is addressed to seek optimal module decomposition by selecting an optimal threshold value. For the liver cancer gene network under study, we obtain a strong threshold value at 0.67302, and a very strong correlation threshold at 0.80086. On the basis of these threshold values, fourteen strong modules and thirteen very strong modules are obtained respectively. A certain degree of correspondence between the two types of modules is addressed as well. Finally, the biological significance of the two types of modules is analyzed and explained, which shows that these modules are closely related to the proliferation and metastasis of liver cancer. This discovery of the new modules may provide new clues and ideas for liver cancer treatment

Double occupancies in confined attractive fermions on optical lattices

We perform a numerical study of a one-dimensional Fermion-Hubbard model in harmonic traps within the Thomas-Fermi approximation based on the exact Bethe-ansatz solution. The $\rho-U/t$ phase diagram is shown for the systems of attractive interactions ($\rho$ is the characteristic density and $U/t$ the interaction strength scaled in units of the hopping parameter.). We study the double occupancy, the local central density and their derivatives. Their roles are discussed in details in detecting the composite phases induced by the trapping potential.Comment: 4 pages, 4 figures, submitte

Sliding mode and shaped input vibration control of flexible systems

Copyright [2008] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to [email protected]. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.In this paper, the vibration reduction problem is investigated for a flexible spacecraft during attitude maneuvering. A new control strategy is proposed, which integrates both the command input shaping and the sliding mode output feedback control (SMOFC) techniques. Specifically, the input shaper is designed for the reference model and implemented outside of the feedback loop in order to achieve the exact elimination of the residual vibration by modifying the existing command. The feedback controller, on the other hand, is designed based on the SMOFC such that the closed-loop system behaves like the reference model with input shaper, where the residual vibrations are eliminated in the presence of parametric uncertainties and external disturbances. An attractive feature of this SMOFC algorithm is that the parametric uncertainties or external disturbances of the system do not need to satisfy the so-called matching conditions or invariance conditions provided that certain bounds are known. In addition, a smoothed hyperbolic tangent function is introduced to eliminate the chattering phenomenon. Compared with the conventional methods, the proposed scheme guarantees not only the stability of the closed-loop system, but also the good performance as well as the robustness. Simulation results for the spacecraft model show that the precise attitudes control and vibration suppression are successfully achieved