A LID APPROACH FOR PREDICTING WAVE INDUCED MOTIONS OF TRIMARAN IN REGULAR WAVES

The wave induced motions of a trimaran sailing in regular head waves were predicted by using the three dimensional boundary integral method. Large wave elevation on the free surface in between the trimaran’s main-hull and the outriggers occurred at some specific frequencies in the numerical model. The large wave elevation also induced large heave and pitch motions of trimaran. However, the large wave elevation and corresponding large motions were not observed during towing tank tests. A lid approach was introduced in this paper by placing lid on the free surface in between hulls to suppress the unrealistically large wave elevation and to correctly predict the induced motions of trimaran. The feasibility and practicability of lid approach were validated against experimental results

Examining the relationship between meeting 24-hour movement behaviour guidelines and mental health in Chinese preschool children

BackgroundLimited research has explored the relationship between adhering to 24-h Movement Behaviour guidelines and mental health in Chinese preschool children. The objectives of this study encompassed two primary goals: (1) to investigate the adherence of preschool children in China to the 24-h Movement Behaviour guidelines; and (2) to analyze the relationship between fulfilling various combinations of these guidelines and mental health, identifying the most advantageous combination.MethodsUtilizing a convenience sampling approach, this study included 205 preschool children (117 boys and 88 girls, average age 4.8 ± 0.51 years) from five kindergartens in Hengyang, Hunan Province. The physical activity (PA) and sedentary behaviour of preschool children were objectively assessed using waist-worn accelerometers, while sleep duration and screen time were reported by the children's parents. To evaluate mental health, the parent version of the internationally validated Strength and Difficulties Questionnaire (SDQ) was employed, which measures externalizing problems, internalizing problems, and prosocial behaviour. Employing Mplus 8.0 for Structural Equation Modeling analysis, while controlling for demographic variables, the study explored the connection between preschool children's mental health and their adherence to the 24-h Movement Behaviour guidelines.ResultsWorryingly, merely 14.6% of preschoolers met the recommended guidelines for all three aspects (PA, sleep duration, and screen time). Positive correlations were identified between meeting PA guidelines and displaying prosocial behaviour (β = 0.184; p < 0.05), while screen time adherence exhibited a negative correlation with externalizing problems (β = −0.207; p < 0.05). Similarly, there was a negative association between sleep duration adherence and externalizing problems (β = −0.191; p < 0.05). Meeting all three recommended guidelines was notably linked to enhanced prosocial behaviour (β = 0.464; p < 0.05), while following the screen time and sleep duration guidelines was negatively associated with externalizing problems (β = −0.246; p < 0.05).ConclusionThis study underscores the limited adherence of Chinese preschoolers to the comprehensive 24-h Movement Behaviour guidelines. Noteworthy findings include the positive influence of PA on prosocial behaviour, alongside the significant roles that sleep duration and screen time play in mitigating externalizing problems within this age group. Alignment with the 24-h Movement Behaviour guidelines is associated with more favorable mental health indicators in preschoolers

Isotemporal substitution effect of 24-hour movement behavior on the mental health of Chinese preschool children

The 24-h movement behavior of preschoolers comprises a spectrum of activities, including moderate-to-vigorous intensity physical activity (MVPA), light-intensity physical activity (LPA), screen-based sedentary behavior (SCSB), non-screen-based sedentary behavior (NSCSB), and sleep. While previous research has shed light on the link between movement behaviors and children’s mental health, the specific impacts on the unique demographic of Chinese preschoolers remain underexplored. This study significantly contributes to the literature by exploring how 24-h movement behavior affects the mental health of preschoolers in a Chinese context. The study involved205 Chinese preschool children (117 boys and 88 girls) between the ages of 3 and 6 years wore accelerometers to measure their LPA, MVPA, and sedentary behavior (SB), while their parents reported the time spent on sleep and SCSB. The parents also completed the Strength and Difficulties Questionnaire to assess their children’s mental health. The study used compositional regression and isotemporal substitution models to examine the relationship between the various components of 24-h movement behavior and mental health. The results showed that greater NCSSB compared to MVPA, LPA, sleep, and SCSB was associated with good prosocial behavior and lower scores on externalizing problems. This highlights the potential of NSCSB as a beneficial component in the daily routine of preschoolers for fostering mental well-being. Replacing 15 min of sleep and SCSB with 15 min of NSCSB was associated with a decrease of 0.24 and 0.15 units, respectively, in externalizing problems. Reallocating 15 min of sleep to NSCSB was linked to an increase of 0.11 units in prosocial behavior. There were no significant substitution effects between LPA and MVPA time with any other movement behavior on prosocial behavior and externalizing problems. Given the positive associations observed, further longitudinal studies are necessary to explore the link between 24-h movement behavior and mental health in preschool children

Clinical and radiological characteristics of pediatric COVID-19 before and after the Omicron outbreak: a multi-center study

IntroductionThe emergence of the Omicron variant has seen changes in the clinical and radiological presentations of COVID-19 in pediatric patients. We sought to compare these features between patients infected in the early phase of the pandemic and those during the Omicron outbreak.MethodsA retrospective study was conducted on 68 pediatric COVID-19 patients, of which 31 were infected with the original SARS-CoV-2 strain (original group) and 37 with the Omicron variant (Omicron group). Clinical symptoms and chest CT scans were examined to assess clinical characteristics, and the extent and severity of lung involvement.ResultsPediatric COVID-19 patients predominantly had normal or mild chest CT findings. The Omicron group demonstrated a significantly reduced CT severity score than the original group. Ground-glass opacities were the prevalent radiological findings in both sets. The Omicron group presented with fewer symptoms, had milder clinical manifestations, and recovered faster than the original group.DiscussionThe clinical and radiological characteristics of pediatric COVID-19 patients have evolved with the advent of the Omicron variant. For children displaying severe symptoms warranting CT examinations, it is crucial to weigh the implications of ionizing radiation and employ customized scanning protocols and protective measures. This research offers insights into the shifting disease spectrum, aiding in the effective diagnosis and treatment of pediatric COVID-19 patients

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

Sir2, a NAD-dependent deacetylase, modulates lifespan in yeasts, worms and flies. The SIRT1, mammalian homologue of Sir2, regulates signaling for favoring survival in stress. But whether SIRT1 has the function to influence cell viability and senescence under non-stressed conditions in human diploid fibroblasts is far from unknown. Our data showed that enforced SIRT1 expression promoted cell proliferation and antagonized cellular senescence with the characteristic features of delayed Senescence-Associated β-galactosidase (SA-β-gal) staining, reduced Senescence-Associated Heterochromatic Foci (SAHF) formation and G1 phase arrest, increased cell growth rate and extended cellular lifespan in human fibroblasts, while dominant-negative SIRT1 allele (H363Y) did not significantly affect cell growth and senescence but displayed a bit decreased lifespan.. Western blot results showed that SIRT1 reduced the expression of p16INK4A and promoted phosphorylation of Rb. Our data also exposed that overexpression of SIRT1 was accompanied by enhanced activation of ERK and S6K1 signaling. These effects were mimicked in both WI38 cells and 2BS cells by concentration-dependent resveratrol, a SIRT1 activator. It was noted that treatment of SIRT1-.transfected cells with Rapamycin, a mTOR inhibitor, reduced the phosphorylation of S6K1 and the expression of Id1, implying that SIRT1-induced phosphorylation of S6K1 may be partly for the decreased expression of p16INK4A and promoted phosphorylation of Rb in 2BS. It was also observed that the expression of SIRT1 and phosphorylation of ERK and S6K1 was declined in senescent 2BS. These findings suggested that SIRT1-promoted cell proliferation and antagonized cellular senescence in human diploid fibroblasts may be, in part, via the activation of ERK/ S6K1 signaling

Developments and Prospects of Long-Span High-Speed Railway Bridge Technologies in China

With the rapid developments of the high-speed railway in China, a great number of long-span bridges have been constructed in order to cross rivers and gorges. At present, the longest main span of a constructed high-speed railway bridge is only 630 m. The main span of Hutong Yangtze River Bridge and of Wufengshan Yangtze River Bridge, which are under construction, will be much longer, at 1092 m each. In order to overcome the technical issues that originate from the extremely large dead loading and the relatively small structural stiffness of long-span high-speed railway bridges, many new technologies in bridge construction, design, materials, and so forth have been developed. This paper carefully reviews progress in the construction technologies of multi-function combined bridges in China, including combined highway and railway bridges and multi-track railway bridges. Innovations and practices regarding new types of bridge and composite bridge structures, such as bridges with three cable planes and three main trusses, inclined main trusses, slab-truss composite sections, and steel-concrete composite sections, are introduced. In addition, investigations into high-performance materials and integral fabrication and erection techniques for long-span railway bridges are summarized. At the end of the paper, prospects for the future development of long-span high-speed railway bridges are provided. Keywords: High-speed railway, Long-span bridges, Multi-function combined bridges, High-performance materials, Spatial structures with three cable planes, Integral fabricatio

Study on Influence of Diversified Parameters of Vehicle and Track on Wheel Hollow Wear

Wheel hollow wear of high-speed train is one of the main damage types for the wheel. By optimizing the vehicle and track parameters and matching the wheel-rail profile, the hollow wear of wheel can be reduced. In order to study the sensitivity of vehicle and track parameters to the wheel hollow wear, the sensitivity of suspension parameters and the track parameters of the CRH2Ctype high-speed train wheel on the hollow wear of the wheel was studied by the parameter sensitivity analysis method. The concept of the cumulative wear power dissipation was put forward. The distribution characteristics of the wheel hollow wear under the different wheel/rail treads matching were forecasted. The results show that the damping of antihunting motion damper of the vehicle is the most sensitive to the maximum cumulative wear power dissipation of the wheel, followed by the longitudinal stiffness of tumbler journal box node, lateral stiffness of air-spring suspension, vertical damping of primary suspension, vertical stiffness of track, and vertical damping of track. According to the analysis from the combination of sensitive parameters, the cumulative wear power dissipation is unevenly distributed in the lateral direction of the wheel tread and has the obvious peak area, which is basically the same as the actual wear distribution location in the field. The matching of the LMA wheel tread and the CN60N rail tread is a good choice to slow down the hollow wear and reduce the wheel wear rate. And the wheel reprofiling should be timely carried out, otherwise the wear rate would increase and the hollow wear would become more serious

Exploring the Rate-Distortion-Complexity Optimization in Neural Image Compression

Despite a short history, neural image codecs have been shown to surpass classical image codecs in terms of rate-distortion performance. However, most of them suffer from significantly longer decoding times, which hinders the practical applications of neural image codecs. This issue is especially pronounced when employing an effective yet time-consuming autoregressive context model since it would increase entropy decoding time by orders of magnitude. In this paper, unlike most previous works that pursue optimal RD performance while temporally overlooking the coding complexity, we make a systematical investigation on the rate-distortion-complexity (RDC) optimization in neural image compression. By quantifying the decoding complexity as a factor in the optimization goal, we are now able to precisely control the RDC trade-off and then demonstrate how the rate-distortion performance of neural image codecs could adapt to various complexity demands. Going beyond the investigation of RDC optimization, a variable-complexity neural codec is designed to leverage the spatial dependencies adaptively according to industrial demands, which supports fine-grained complexity adjustment by balancing the RDC tradeoff. By implementing this scheme in a powerful base model, we demonstrate the feasibility and flexibility of RDC optimization for neural image codecs