The correspondence between shadows and test fields in four-dimensional charged Einstein-Gauss-Bonnet black holes

In this paper, we investigate the photon sphere, shadow radius and quasinormal modes of a four-dimensional charged Einstein-Gauss-Bonnet black hole. The perturbation of a massless scalar field in the background of the black hole is adopted. The quasinormal modes are gotten by the $6th$ order WKB approximation approach and shadow radius, respectively. The degree of coincidence of the quasinormal modes derived by the two approaches increases with the increase of the values of the Gauss-Bonnet coupling constant and multiple number. It shows the correspondence between the shadow and test field in the four-dimensional Einstein-Gauss-Bonnet-Maxwell gravity. The radii of the photon sphere and shadow increase with the decrease of the Gauss-Bonnet coupling constant.Comment: 16 page

Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis

Glutathione S-transferase (GST) is the key enzyme in multidrug resistance (MDR) of tumour. Inhibition of the expression or activity of GST has emerged as a promising therapeutic strategy for the reversal of MDR. Coniferyl ferulate (CF), isolated from the root of Angelica sinensis (Oliv.) Diels (Radix Angelicae sinensis, RAS), showed strong inhibition of human placental GST. Its 50% inhibition concentration (IC50) was 0.3 μM, which was greater than a known GSTP1-1 inhibitor, ethacrynic acid (EA), using the established high-throughput screening model. Kinetic analysis and computational docking were used to examine the mechanism of GST inhibition by CF. Computational docking found that CF could be fully docked into the gorge of GSTP1-1. The further exploration of the mechanisms showed that CF was a reversible noncompetitive inhibitor with respect to GSH and CDNB, and it has much less cytotoxicity. Apoptosis and the expression of P-gp mRNA were evaluated in the MDR positive B-MD-C1 (ADR+/+) cell line to investigate the MDR reversal effect of CF. Moreover, CF showed strong apoptogenic activity and could markedly decrease the overexpressed P-gp. The results demonstrated that CF could inhibit GST activity in a concentration-dependent manner and showed a potential MDR reversal effect for antitumour adjuvant therapy

Network Pharmacology Based Research on the Combination Mechanism Between Escin and Low Dose Glucocorticoids in Anti-rheumatoid Arthritis

Rheumatoid arthritis (RA) is characterized by chronic progressive symmetrical synovitis and destruction of multiple joints. Glucocorticoids (GCs) are widely used in the treatment of RA. However, their adverse effects can be serious. Escin, which is isolated from Aesculus hippocastanum L., has been reported to have anti-inflammatory effects. We investigated the anti-RA effect of Escin combined with low dose GCs (dexamethasone, Dex) and the underlying mechanism. Adjuvant-induced RA rats and lipopolysaccharides (LPS)-injured RAW264.7 cells were used to investigate the anti-RA effects of Escin combined with low dose Dex in vivo and in vitro. The results showed that Escin combined with low-dose Dex significantly decreased arthritic index, serum IL-6 and TNF-α levels, reduced paw swelling, and ameliorated the joint pathology and immune organ pathology. Gene chip results revealed that Nr3c1 (GR) expression was significantly altered, and that GR was activated by Escin and low dose Dex in vivo and in vitro. Additionally, Escin combined with low dose Dex also significantly increased GR mRNA expression. However, when GR expression was suppressed by its specific inhibitor, the anti-RA effect of Escin combined with low-dose Dex was abolished. The data in this study demonstrated that Escin combined with Dex reduced the dose of Dex, and exerted significant anti-RA effects, which could also reduce the adverse effects of Dex. This combination might result from GR activation. This study might provide a new combination of drugs for the treatment of RA

The bound of Lyapunov exponent in Einstein-Maxwell-Dilaton-Axion black holes

In this paper, we investigate the influence of the angular momentum of a charged particle on the bound of the Lyapunov exponent in non-extremal and extremal Einstein-Maxwell-Dilaton-Axion black holes. The derivation of the exponent relies on the effective potential of the particle. We find that when the angular momentum takes specific values, the bound is violated at the certain distances from the event horizons. This violation always exists when the rotation parameter of the black holes is large enough and the rotation direction of the particle is opposite to that of the black holes. In the near-horizon regions, the violation of the bound depends on the rotation directions of the extremal black hole and particle, and does not depend on the value of the angular momentum of the particle in the non-extremal black hole.Comment: 16 page

The correspondence between shadow and test field in a four-dimensional charged Einstein–Gauss–Bonnet black hole

In this paper, we investigate the photon sphere, shadow radius and quasinormal modes of a four-dimensional charged Einstein–Gauss–Bonnet black hole. The perturbation of a massless scalar field in the black hole’s background is adopted. The quasinormal modes are gotten by the 6th order WKB approximation approach and shadow radius, respectively. When the value of the Gauss–Bonnet coupling constant increase, the values of the real parts of the quasinormal modes increase and those of the imaginary parts decrease. The coincidence degrees of quasinormal modes derived by the two approaches increases with the increase of the values of the Gauss–Bonnet coupling constant and multipole number. It shows the correspondence between the shadow and test field in the four-dimensional Einstein–Gauss–Bonnet–Maxwell gravity. The radii of the photon sphere and shadow increase with the decrease of the Gauss–Bonnet coupling constant

The Source Areas and Migratory Pathways of the Fall Armyworm Spodoptera frugiperda (Smith) in Sichuan Province, China

The Sichuan Province, located in Southwest China, is one of China’s main maize-producing areas, and is also an important node along the north-south migratory pathways that pests follow within China. After its invasion, the fall armyworm (FAW), Spodoptera frugiperda (Smith), was found in 70.81% of all counties in Sichuan. However, FAW source areas and their migratory pathways into Sichuan remain unclear. This study simulated FAW sources and their migratory pathways into Sichuan during 2020 and 2021 using the trajectory simulation platform HYSPLIT with flight behavior parameters. Additionally, the seasonal horizontal wind field was also analyzed with the meteorological graphics processing software GrADS. The results showed that sporadic FAW migration into Sichuan began in April. By May, FAWs were found in much of the Sichuan Basin and moved further north and west in June. Except for year-round breeding areas, FAW sources varied monthly and expanded northward and eastward. The source areas were concentrated in Yunnan, Guizhou, Chongqing, and Myanmar on the western pathway of national migration and also in Vietnam, Guangxi, and Hunan of the eastern pathway. At various times, parts of Sichuan have also served as sources for other parts of Sichuan. FAWs migrated to Sichuan from the source areas via 6 potential pathways, 1 pathway into southwest Sichuan and 5 pathways into the Sichuan basin. The southwestern airflow from the Bay of Bengal, the southeastern airflow controlled by the western Pacific subtropical high, and the local topographically influenced airflow could provide the airflow needed for FAW migration. This work provides new information that can assist the monitoring and warning of the presence of FAW and support integrated management strategies for this pest in Sichuan and throughout China

Growth of \u27W\u27 doped molybdenum disulfide on graphene transferred molybdenum substrate

In the present study, a novel method has been carried out to grow tungsten (W) doped molybdenum disulfide (MoS 2 ) on the graphene transferred TEM grid in a chemical vapor deposition (CVD) setup. Tungsten trioxide (WO 3 ) has been used as a source for \u27W\u27 while \u27Mo\u27 has been derived from Mo based substrate. Different experimental parameters were used in this experiment. Higher gas flow rate decreases the size of the sample flake and on other side increases the dopant concentrations. The interaction mechanism between Mo, S, W and oxygen (O) have been explored. The influence of oxygen seems to be not avoidable completely which also imposes effective growth condition for the reaction of Mo with incoming sulfur atoms. The difference in the migration energies of Mo, WO 3 , S clusters on the graphene and the higher reactivity of Mo clusters over other possibly formed atomic clusters on the graphene leads to the growth of W doped MoS 2 monolayers. Formation of MoS 2 monolayer and the nature of edge doping of \u27W\u27 is explained well with the crystal model using underlying nucleation principles. We believe our result provide a special route to prepare W doped MoS 2 on graphene substrate in the future

Diethyl Blechnic, a Novel Natural Product Isolated from Salvia miltiorrhiza Bunge, Inhibits Doxorubicin-Induced Apoptosis by Inhibiting ROS and Activating JNK1/2

Doxorubicin (DOX) is a widely used antineoplastic agent in clinics. However, its clinical application is largely limited by its cardiotoxicity. Diethyl blechnic (DB) is a novel compound isolated from Salvia miltiorrhiza Bunge. Here, we study the effect of DB on DOX-induced cardiotoxicity and its underlying mechanisms. Cellular viability was tested by 3-[-4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and protein level was evaluated by Western blotting. 5,5’,6,6’-tetrachloro-1,1’,3,3’-tetraethylbenzimidazolylcarbocyanine iodide (JC-1) staining was performed to determine the mitochondrial membrane potential (MMP). Hoechst 33342 staining and TUNEL staining was performed to test the apoptosis. Reactive oxygen species (ROS) generation was investigated by using flow cytometry. DB significantly inhibited DOX-induced apoptosis in H9c2 cells and primary cultured cardiomyocytes. Moreover, DB decreased cell apoptotic morphological changes and reversed the mitochondrial membrane potential induced by DOX. Meanwhile, pre-treatment with DB increased the expression levels of B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra-large (Bcl-xl), and survivin and reduced the expression levels of Bcl-2-associated X protein (Bax), p-p53, cytochrome c (cyt c), and cleaved-caspase 3, 7, 8, 9 in the protein levels in DOX-treated H9c2 cells. Furthermore, DB suppressed ROS generation. The DB-mediated protective effects were accompanied by increased c-Jun N-terminal kinase1/2 (JNK1/2) expression. In addition, SP600125, the inhibitor of JNK1/2, abolished the protective effect of DB. We concluded that DB protected cardiomyocytes against DOX-induced cytotoxicity by inhibiting ROS and activating the JNK1/2 pathway. Therefore, DB is a promising candidate as a cardioprotective agent against DOX-induced cardiotoxicity