Alzheimer's disease and Parkinson dementia distinguished by cognitive marker

Background:  Temporary memory binding (TMB) has been shown to be specifically affected by Alzheimer’s disease (AD) when it is assessed via free recall and titrating the task demands to equate baseline performance across patients. Methods:  Patients with Parkinson’s disease (PD) were subdivided into patients with and without cognitive impairment and compared with AD and amnestic mild cognitive impairment (aMCI) patients on their performance on the TMB. Results:  The results show that only patients with AD dementia present with impaired TMB performance. Receiver operating characteristic curve analyses showed that TMB holds high sensitivity and specificity for aMCI and AD relative to PD groups and healthy controls. Conclusion:  The TMB is sensitive to the neurodegenerative mechanisms leading to AD dementia but not to those underpinning PD dementia. As such, TMB task can aid the differential diagnosis of these common forms of dementia

Alzheimer disease and Parkinson dementia distinguished by cognitive marker

Background: Temporary Memory Binding (TMB) has been shown to be specifically affected by Alzheimer's Disease (AD) when it is assessed via free recall and titrating the task demands to equate baseline performance across patients. Methods: Patients with PD were subdivided into patients with and without cognitive impairment and compared with AD and amnestic MCI (aMCI) patients on their performance on the TMB. Results: The results show that only patients with AD dementia present with impaired TMB performance. ROC analyses showed that TMB holds high sensitivity and specificity for aMCI and AD relative to PD groups and healthy controls. Conclusion: TMB is sensitive to the neurodegenerative mechanisms leading to AD dementia but not to those underpinning PD dementia. As such, TMB task can aid the differential diagnosis of these common forms of dementia

From Harare to Rio de Janeiro : Kukiya-Favela organization of the excluded

This article, based on ethnographic research conducted with people in Brazil and Zimbabwe, reports organization/management experiences and narratives of poor and marginalized people of the south. South embodies the organizational struggle, survival skills and resilience of marginal and urban outcasts that inhabit inner cities, townships and slums. The article employs the notion of kukiya-favela organization, i.e. the organization of the excluded, to engage with them in order to: give voice to those who dwell at the margins of organization studies; make their narratives part of a subject that retains an elitist position; and re-address the Eurocentric management/organization discourse that imposes a legitimate justification for exploiting, excluding and labelling them as organization-less and urban outcasts of society. The article concludes that despite their marginality and exclusion they are able to construct local diverse meaningful (organizational) identities that can represent them with dignity in their struggle for justice and basic human rights. Finally, it reflects on the contribution this has for us, in organization studies, by opening new spaces for the study of organization[al] (lives) not from positions of ‘above’ or ‘against’ but ‘with’ (Gergen, 2003: 454)