26 research outputs found
Low grade Endometrial Stromal Sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases
BACKGROUND: Endometrial stromal sarcoma (ESS) is a rare disease with probably less than 700 new cases in the USA or Europe per year. The aim of this study was to evaluate the behavior of low-grade endometrial stromal sarcoma (LGESS) in relation to their clinical and pathological features and to identify possible prognostic factors. PATIENTS AND METHODS: Fourteen patients with histologically proven ESS were included in the analysis. Endometrial stromal sarcoma is characterized by proliferations composed of cells with Endometrial stromal cell differentiation. Low-grade endometrial stromal sarcoma has an infiltrating margin and typically show extensive worm-like vessel invasion. RESULTS: The median age was 44.35 ± 6 years. The most common presenting symptom was vaginal bleeding, occurring in twelve patients (86%). Diagnosis was made through Fractional dilatation and curettage in four patients (28.5%). Eight patients had a total abdominal hysterectomy and salpingo-ophorectomy (57%). Radiotherapy as adjuvant therapy was administered to four patients (28.5%). The median follow-up time was 45.6 months (range 24–84). The median overall survival of the 14 patients was 45.35 ± 21 months (range 20–83). Three of 14 patients demonstrated a recurrence of disease at 9, 72, and 96 months respectively. The recurrent diseases were treated with surgery, chemotherapy, and radiotherapy. No patient died of the disease. Clinico-pathological parameters did not significantly differ between patients with and without recurrence, but patients with no myometrial invasion and low mitotic count <= 5/HPF showed longer disease-free survival. CONCLUSION: Five-year survival rate was 93%. Survival probabilities were calculated by the product limit method of Kaplan and Meier that showed, patients with no myometrial invasion and low mitotic count <= 5/HPF have longer disease-free survival, but P value was not significant
Prevalence of Persistent Hypertension Following Delivery Complicated by Hypertensive Disorders and Related Obstetric and Laboratory Risk Factors
This study examined prevalence of persistent hypertension following delivery complicated by hypertensive disorders and related obstetric and laboratory risk factors. This prospective cohort study was conducted in a teaching medical center on 270 women with more than 20 weeks of gestation who were admitted for examination and management of high blood pressure. The patients were followed up for blood pressure in two visits at 6 and 12 weeks postpartum. After 12 weeks, women were assigned to three groups of healthy, prehypertension and persistent hypertension. Background information was reviewed to find independent factors associated with persistency of blood pressure using statistical t-test and logistic regression. In bivariate analysis, relative risk of persistent hypertension was estimated at 95% confidence interval. Of 270 patients (46.2%), 110 patients developed persistent hypertension. Among risk factors, high BMI, delivery in less than 34 weeks of pregnancy, history of preeclampsia, history of diabetes, severe preeclampsia and drug control for PIH were independently associated with persistent hypertension. Abnormal laboratory findings included thrombocytopenia, increased serum uric acid and serum creatinine and severe proteinuria associated with this disorder (P <0.05). Almost one in every two pregnant women with hypertensive disorders was prone to postpartum persistent hypertension. This risk particularly increased in maternal obesity, preterm birth due to preeclampsia and abnormal laboratory findings indicating severe preeclampsia. Therefore, more detailed follow-up of high-risk patients is recommended in puerperal visits for diagnosis and timely treatment
Investigating the Effect of Oil Revenue Shocks on Business Cycles and the Synchronism of Cycles with Selected OECD Countries
The effect of temporary and permanent shocks of oil revenues on the concurrence of trade cycles between Iran and selected OECD countries has been investigated using the data series of the period 1985–2019. For this purpose, first, business cycles and temporary and permanent shocks of oil revenues are extracted using Hodrick-Prescott (HP) filter and Blanchard-Quah technique, respectively. Then, the relationship between business cycles and model-independent variables is evaluated by the ARDL method. The results show that the main cause of business cycle fluctuations is temporary shocks to oil revenues, also, government expenditure variables and permanent and temporary shocks to oil revenues in the short and long term have a negative and significant effect on business cycles, and the exchange rate variable has a positive and significant effect on business cycles. Estimation of business cycle synchronization index shows that Belgium, Germany, Greece, Japan, Spain, and Turkey have had business cycles synchronization with Iran. And Germany with a correlation coefficient of 0.42 has the most synchronization of business cycles with Iran
The Effect of 8 Weeks Endurance Training on Serum Levels of IL-10 and IL-8, and White Blood Cell Count in Women with Breast Cancer
Background & Objective: The regular exercise training is known as a preventive and adjuvant therapy in inflammatory diseases such as cancer. The aim of this study was to determine the effect of the aerobic training on IL-10 and IL-8 levels and the count of white blood cells (WBC) in women with breast cancer.
Material & Methods: The statistical society of the present study included Kerman women with breast cancer. Forty patients with breast cancer were randomly divided into two groups: exercise (n = 20) and control (n = 20). The exercise group performed the endurance training for 8 weeks with the intensity between 40 to 55 percent of the target heart rate. Twenty four hours before the first session and 48 hours after the last session of the exercise protocol, blood samples were taken from both groups and then IL-10 and IL-8 levels in serum were measured by ELISA via a Boster kit.
Results: The results of the present study showed that 8 weeks of the endurance exercise training did not significantly increase the IL-10 (P=0.113) serum level, but increased the WBC count (p=0.019) and decreased the serum level of IL-8 (p=0.03) significantly.
Conclusion: According to the results of the present study, regular endurance training via decreasing the inflammatory factors can be considered as an effective factor along with other therapies in improving breast cancer
Primary low-grade endometrial stromal sarcoma arising in the vagina: report of an unusual case and literature review
Low-grade endometrial stromal sarcoma in a postmenopausal woman with third-degree uterovaginal prolapse: A rare case with review of the literature
Complications, Bleeding and Satisfaction of Patients with Abnormal Uterine Bleeding through the Integration of Endometrial Degradation and Thermal Balloon Therapy
BACKGROUND AND OBJECTIVE: In the patients diagnosed with
abnormal uterine bleeding, if the patient does not respond to drug treatment or
is not a good candidate for hysterectomy, endometrial destruction is
recommended. The aim of this study was to evaluate complications, blood loss
and patient satisfaction regarding this method of treatment.
METHODS: This
retrospective study was performed on 56 women who admitted to Ayatollah Roohani
Hospital of Babol and Imam Hossein Hospital in Tehran, Iran. Upon the diagnosis
of abnormal uterine bleeding, they underwent a treatment called
"endometrial destruction by thermal balloon". A questionnaire
including the following items was completed after the sugery: demographic
characteristics, menstrual status, postoperative complications, treatment
success and a 12-month post-surgery patient satisfaction. In order to assess
the patients’ satisfaction, 4 questions were asked (excellent, good, fair,
poor). Successful treatment was defined as 6 months of amenorrhea after treatment with cavaterm and a reduction
in the menstrual blood loss in the form of spotting or volume degression.
FINDINGS: Of the 56 patients who were treated
with balloon thermal endometrial destruction, 4 were excluded due to the lack
of follow-up. The mean age of the patients was 91/5±38/43 years. No
complications occurred in any of the new patients, and the percentage of
amenorrhea was 23 after the treatment. Twelve months after the surgery, the
success of treatment was reported in 46 patients (5/88%) and patient satisfaction
was also rated in 45 of the patients (5/86%).
CONCLUSION: The
results of the study showed that the thermal balloon treatment had no major
side effects. Thus, it could be inferred that the study was a success in terms
of the outcomes and high patient satisfaction. This method could be taken into
consideration before a hysterectomy