Učinci kombinirane terapije reumatoidnog artritisa na reaktante akutne faze

The paper presents the results of studies of acute phase reactants in the 60 treated patients with rheumatoid arthritis. Patients were divided into two groups, depending on the applied treatment: group I (n=30) was treated with methotrexate, sulfasalazine and hydroxychloroquine, and group II (n=30) with methotrexate. The results of our study shows that there is a statistically significant reduction in the value of acute phase reactants and clinical parameters after treatment in both investigated groups of patients, and also a significant statistical difference between the first and second group of treated patients.U radu su prikazani rezultati ispitivanja reaktanata akutne faze u 60 liječenih bolesnika s reumatoidnim artritisom. Bolesnici su bili podijeljeni u dvije skupine, ovisno o primijenjenoj terapiji: I. skupina (n=30) je liječena metotreksatom, sulfasalazinom i hidroksiklorokinom, a II. skupina (n=30) metotreksatom. Rezultati našega istraživanja pokazuju da postoji statistički značajno smanjenje vrijednosti reaktanata akutne faze i kliničkih parametara nakon liječenja u obje ispitivane skupine bolesnika, a također i značajna statistička razlika između prve i druge skupine liječenih bolesnika

Učinci kombinirane terapije reumatoidnog artritisa na reaktante akutne faze

The paper presents the results of studies of acute phase reactants in the 60 treated patients with rheumatoid arthritis. Patients were divided into two groups, depending on the applied treatment: group I (n=30) was treated with methotrexate, sulfasalazine and hydroxychloroquine, and group II (n=30) with methotrexate. The results of our study shows that there is a statistically significant reduction in the value of acute phase reactants and clinical parameters after treatment in both investigated groups of patients, and also a significant statistical difference between the first and second group of treated patients.U radu su prikazani rezultati ispitivanja reaktanata akutne faze u 60 liječenih bolesnika s reumatoidnim artritisom. Bolesnici su bili podijeljeni u dvije skupine, ovisno o primijenjenoj terapiji: I. skupina (n=30) je liječena metotreksatom, sulfasalazinom i hidroksiklorokinom, a II. skupina (n=30) metotreksatom. Rezultati našega istraživanja pokazuju da postoji statistički značajno smanjenje vrijednosti reaktanata akutne faze i kliničkih parametara nakon liječenja u obje ispitivane skupine bolesnika, a također i značajna statistička razlika između prve i druge skupine liječenih bolesnika

Association of interatrial septal abnormalities with cardiac impulse conduction disorders in adult patients: experience from a tertiary center in Kosovo

Interatrial septal disorders, which include: atrial septal defect, patent foramen ovale and atrial septal aneurysm, are frequent congenital anomalies found in adult patients. Early detection of these anomalies is important to prevent their hemodynamic and/or thromboembolic consequences. The aims of this study were: to assess the association between impulse conduction disorders and anomalies of interatrial septum; to determine the prevalence of different types of interatrial septum abnormalities; to assess anatomic, hemodynamic, and clinical consequences of interatrial septal pathologies. Fifty-three adult patients with impulse conduction disorders and patients without ECG changes but with signs of interatrial septal abnormalities, who were referred to our center for echocardiography, were included in a prospective transesophageal echocardiography study. Interatrial septal anomalies were detected in around 85% of the examined patients. Patent foramen ovale was encountered in 32% of the patients, and in combination with atrial septal aneurysm in an additional 11.3% of cases. Atrial septal aneurysm and atrial septal defect were diagnosed with equal frequency in 20.7% of our study population. Impulse conduction disorders were significantly more suggestive of interatrial septal anomalies than clinical signs and symptoms observed in our patients (84.91% vs 30.19%, P=0.002). Right bundle branch block was the most frequent impulse conduction disorder, found in 41 (77.36%) cases. We conclude that interatrial septal anomalies are highly associated with impulse conduction disorders, particularly with right bundle branch block. Impulse conduction disorders are more indicative of interatrial septal abnormalities in earlier stages than can be understood from the patient’s clinical condition

Treatment Benefits on Metabolic Syndrome with Diet and Physical Activity

The research has included 422 patients aged between 25 to 60, of whom 341 were men and 81 women. The purpose of research was to determine impact of diet and physical activity in the treatment of metabolic syndrome during the six month period. Processing of results through descriptive and discriminative analysis have indicated that 6 month treatment with diet and physical activity have had an impact in the: waistline decrease by 6,05 cm or 5,50% among males, and 4,92 cm or 5,10% among females; body mass index (BMI) decrease by 1.78 or 6.20% among males, and 2,3 or 8,16% among females; decrease of blood triglycerides levels by 0,35 mmol/L or 16,28% among males, and 0,27 mmol/L or 13,30% among females; increase of blood cholesterol HDL-C by 0,48 mmol/L or 34,78% among males, and 0,06 mmol/L or 4,28% among females; systolic arterial pressure decreased by 15 mmHg or 10,18%, and diastolic blood pressure by 8,74 mmHg or 9,47% among males, and systolic arterial pressure decreased by 7,39 mmHg or 5,17%, and diastolic blood pressure decreased by 5,18 mmHg or 5,75% among females; the level of blood glucose decreased by 0,45 mmol/L or 7,04% among males, and by 0,64 mmol/L or 9,92% decreased among females. The results show that physical exercise and diet are important factors in reducing the values symptoms of metabolic syndrome. In order to improve symptoms of metabolic syndrome, it is necessary to keep on with healthy diet and physical exercise that means the change of lifestyle

In Vitro Research of the Alteration of Neurons in Vagal Core in Medulla Oblongata at Asphyxic Deaths

The aim of this study was to research the morphological changes of neurons in the vagus nerve nuclei in medulla oblongata in asphyxia related death cases. Morphological changes that were investigated were mainly in the dorsal motor respiratory center (DMRC), nucleus tractus solitarius (nTS) and nucleus ambigus (nA) in the medulla oblongata. In our research, the autopsy material from asphyxia related death cases was used from various etiologies: monoxide carbon (CO), liquid drowning, strangulation, electricity, clinical-pathological death, firing weapon, explosive weapon, sharp and blunt objects and death cases due to accident. The material selected for research was taken from medulla oblongata and lungs from all lobes. The material from the medulla oblongata and lungs was fixed in a 10% solution of buffered formalin. Special histochemical methods for central nervous system (CNS) were employed like: Cresyl echt violet, toluidin blue, Sevier-Munger modification and Grimelius. For stereometrical analysis of the quantitative density of the neurons the universal testing system Weibel M42 was used. The acquired results show that in sudden asphyxia related death cases, there are alterations in the nuclei of vagal nerve in form of: central chromatolysis, axonal retraction, axonal fragmentation, intranuclear vacuolization, cytoplasmic vacuolization, edema, condensation and dispersion of substance of Nissl, proliferation of oligodendrocytes, astrocytes and microglia. The altered population of vagus nerve neurons does not show an important statistica! significarne compared to the overall quantity of the neurons in the nuclei of the vagus nerve (p<0,05)